Variation of Urinary and Serum Trace Elements (Ca, Zn, Cu, Se) in Bladder Carcinoma in China

Guo, Kun-Feng; Zhang, Zhe; Wang, Jun-Yong; Gao, Shenglin; Liu, Jiao; Zhan, Bo; Chen, Zhipeng; Kong, Chuize

doi:10.7314/apjcp.2012.13.5.2057

Cited by 16 publications

(5 citation statements)

References 36 publications

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“…Our mixture analysis found no statistically significant association between the toenail trace elements as a mixture and bladder cancer risk, but did suggest higher zinc may be associated with an increased risk. The weight for medium-level zinc (116.7–145.5 μg/g) vs. low-level zinc (39.5–116.2 μg/g) was positively associated with bladder cancer risk, which is consistent with previous studies of urinary zinc 20 , 26 , 27 , but in the opposite direction of previous studies of serum zinc 26 , 28 , 29 . Previous studies have observed that high arsenic concentration in drinking water is associated with higher bladder cancer risk 15 , 30 , 31 , yet studies of toenail arsenic have reported no association with bladder cancer risk 32 or associations only in subgroups such as smokers 33 .…”

Section: Discussionsupporting

confidence: 88%

Adaptive-mixture-categorization (AMC)-based g-computation and its application to trace element mixtures and bladder cancer risk

Jackson

Passarelli

et al. 2022

Sci Rep

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Several new statistical methods have been developed to identify the overall impact of an exposure mixture on health outcomes. Weighted quantile sum (WQS) regression assigns the joint mixture effect weights to indicate the overall association of multiple exposures, and quantile-based g-computation is a generalized version of WQS without the restriction of directional homogeneity. This paper proposes an adaptive-mixture-categorization (AMC)-based g-computation approach that combines g-computation with an optimal exposure categorization search using the F statistic. AMC-based g-computation reduces variance within each category and retains the variance between categories to build more powerful predictors. In a simulation study, the performance of association analysis was improved using categorizing by AMC compared with quantiles. We applied this method to assess the association between a mixture of 12 trace element concentrations measured from toenails and the risk of non-muscle invasive bladder cancer. Our findings suggested that medium-level (116.7–145.5 μg/g) vs. low-level (39.5–116.2 μg/g) of toenail zinc had a statistically significant positive association with bladder cancer risk.

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Section: Discussionsupporting

confidence: 88%

Adaptive-mixture-categorization (AMC)-based g-computation and its application to trace element mixtures and bladder cancer risk

Jackson

Passarelli

et al. 2022

Sci Rep

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“…A series of researches have reported the relationship between copper and BC ( Konukoğlu et al, 1996 ; Lin et al, 2009 ; Mazdak et al, 2010 ; Gecit et al, 2011 ; Guo et al, 2012 ). Moreover, copper complex [Cu II 2 Cu I (L) 2 (Br) 3 ] have been found to succeed inducing apoptosis in pancreatic cancer, such as tolfenamic acid–Cu II) complex and Cu II) complex of ketoprofen-salicylhydrazone (FPA-306) ( Hurtado et al, 2018 ; Gou et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

A novel cuproptosis-related lncRNA signature predicts prognosis and therapeutic response in bladder cancer

et al. 2023

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Bladder cancer (BC) ranks the tenth in the incidence of global tumor epidemiology. LncRNAs and cuproptosis were discovered to regulate the cell death. Herein, we downloaded transcriptome profiling, mutational data, and clinical data on patients from The Cancer Genome Atlas (TCGA). High- and low-risk BC patients were categorized. Three CRLs (AL590428.1, AL138756.1 and GUSBP11) were taken into prognostic signature through least absolute shrinkage and selection operator (LASSO) Cox regression. Worse OS and PFS were shown in high-risk group (p < 0.05). ROC, independent prognostic analyses, nomogram and C-index were predicted via CRLs. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated IncRNAs play a biological role in BC progression. Immune-related functions showed the high-risk group received more benefit from immunotherapy and had stronger immune responses, and the overall survival was better (p < 0.05). Finally, a more effective outcome (p < 0.05) was found from clinical immunotherapy via the TIDE algorithm and many potential anti-tumor drugs were identified. In our study, the cuproptosis-related signature provided a novel tool to predict the prognosis in BC patients accurately and provided a novel strategy for clinical immunotherapy and clinical applications.

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“…There may be a range of selenium that offers optimal protection against cancer development in general, as a deficiency in selenium has been associated with an increased risk of cancer, this association having been evidenced for selenium in hair and nails and prostate cancer in Malaysia (Karimi et al, 2012), and selenium in serum and, respectively bladder carcinoma in China (Guo et al, 2012), and breast cancer in India (Singh et al, 2005). In the latter case-control study, it has been estimated that each increase of one μ mol/l of selenium was associated to decrease in 7% of breast cancer risk (Singh et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…Although numerous studies have shown that selenium deficiency may be associated with an increased risk for several types of cancer (Willett et al, 1983;Clark et al, 1996;Duffield-Lillico et al, 2002;Guo et al, 2012), the relationship between selenium and thyroid cancer has been examined in few studies. One in vitro study showed that selenium causes growth inhibition of thyroid cancer cells accompanied by cell-cycle arrest in the S and G2/M phases (Kato et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

Ren

Kitahara²,

González³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Numerous studies have suggested that selenium deficiency may be associated with an increased risk for several types of cancer, but few have focused on thyroid cancer. Materials and Methods: We examined the association between post-diagnostic fingernail selenium levels and differentiated thyroid cancer risk in a French Polynesian matched case-control study. Conditional logistic regression models were used to estimate odds ratios and 95% confidence intervals. Results: The median selenium concentration among controls was 0.76 μg/g. Significantly, we found no association between fingernail selenium levels and thyroid cancer risk after conditioning on year of birth and sex and additionally adjusting for date of birth (highest versus lowest quartile: odds-ratio=1.12, 95% confidence interval: 0.66-1.90; p-trend=0.30). After additional adjustment for other covariates, this association remained non-significant (p-trend=0.60). When restricting the analysis to thyroid cancer of 10 mm or more, selenium in nails was non-significantly positively linked to thyroid cancer risk (p-trend=0.09). Although no significant interaction was evidenced between iodine in nails and selenium in nails effect (p=0.70), a non-significant (p-trend =0.10) positive association between selenium and thyroid cancer risk was seen in patients with less than 3 ppm of iodine in nails. The highest fingernail selenium concentration in French Polynesia was in the Marquises Islands (M=0.87 μg/g) and in the Tuamotu-Gambier Archipelago (M=0.86 μg/g). Conclusions: Our results do not support, among individuals with sufficient levels of selenium, that greater long-term exposure to selenium may reduce thyroid cancer risk. Because these findings are based on post-diagnostic measures, studies with prediagnostic selenium are needed for corroboration.

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Variation of Urinary and Serum Trace Elements (Ca, Zn, Cu, Se) in Bladder Carcinoma in China

Cited by 16 publications

References 36 publications

Adaptive-mixture-categorization (AMC)-based g-computation and its application to trace element mixtures and bladder cancer risk

Adaptive-mixture-categorization (AMC)-based g-computation and its application to trace element mixtures and bladder cancer risk

A novel cuproptosis-related lncRNA signature predicts prognosis and therapeutic response in bladder cancer

Lack of Association between Fingernail Selenium and Thyroid Cancer Risk: A Case-Control Study in French Polynesia

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