Variation of Regulatory T Lymphocytes in the Peripheral Blood of Children with Allergic Rhinitis

Abstract

The studies of T-regulatory (Treg) cells in the pediatric allergic disorders, especially allergic rhinitis (AR), are very few and still far from being elucidated. The aim of this study is to assess the frequencies of CD4CD25Foxp3 (CD4Tregs) and CD8CD25Foxp3 (CD8Tregs) regulatory T lymphocytes in the peripheral blood of children with AR. In fresh whole blood of 60 children with AR and 40 healthy controls, the frequencies of CD4Tregs and CD8Tregs were examined by flow cytometry. The total IgE concentration in the serum was measured. In AR children, the frequencies of CD4Tregs and CD8Tregs were significantly reduced when compared to control group (p = 0.041, p = 0.011, respectively). Moreover, the expressions of Foxp3 in CD4CD25 and CD8CD25 cells were significantly lower in patient group than controls. We found a significant negative correlation between the frequencies of CD4Tregs and the total IgE concentration (p < 0.01). In conclusion, the present study demonstrated that the percentages of CD8Tregs and CD4Tregs T cells were significantly decreased in children with AR. This suggests that decreased Treg cells might represent a defect in the compartment of T-cell population in children with AR. Further studies are warranted to fully appreciate the clinical relevance of Tregs in children with AR.

CD8+ Tregs ameliorate inflammatory reactions in a murine model of allergic rhinitis

“…We found the percentage of CD8 + Tregs in total CD8 + T cells in AR mice was decreased significantly compared with that in normal mice, which might suggest their possible suppressive capacity at the mucosal site through cell–cell contacts or other ways in the allergic inflammation. The data might not be novel, but might confirm what was previously suggested or demonstrated particularly in the AR condition [ 29 ]. Tregs deficiencies might not be the primary cause of allergy as previously suggested [ 30 ].…”

CD8+ Tregs Ameliorate Inflammatory Reactions in a Murine Model of Allergic Rhinitis

“…We found the percentage of CD8 + Tregs in total CD8 + T cells in AR mice was decreased signi cantly compared with that in normal mice, which might suggest their possible suppressive capacity at the mucosal site through cell-cell contacts or other ways in the allergic in ammation. The data might not be novel, but might con rm what was previously suggested or demonstrated particularly in the AR condition [29]. Tregs de ciencies might not be the primary cause of allergy as previously suggested.…”

Vitamin D Status in Egyptian Children With Allergic Rhinitis

“…1,2 Patients usually presented with paroxysmal sneezing, watery rhinorrhea, and nasal blockage. 3 At present, AR is considered a major health problem affecting up to 40% of children worldwide, which may interfere with sleep and quality of life in AR children and impose a considerable burden on public health in economic terms. 1,3 The exact etiology of AR remains poorly understood, and it is an active area of research.…”

“…3 At present, AR is considered a major health problem affecting up to 40% of children worldwide, which may interfere with sleep and quality of life in AR children and impose a considerable burden on public health in economic terms. 1,3 The exact etiology of AR remains poorly understood, and it is an active area of research. 2 Vitamin D deficiency is progressively documented as a possible etiologic or disease-modifying factor in many allergic disorders, including asthma, 4 eczema, 5 and food allergy.…”