Variation of product identity as a function of metal ion: ligand reaction ratio, stereochemical studies and thermal investigation of Mn(II), Fe(III), N

Perlepes, Spyros P.; Kovala‐Demertzi, Dimitra; Skaribas, S. P.; Nicholls, David; Paraskevas, S. M.

doi:10.1016/0040-6031(89)85172-x

Cited by 17 publications

(2 citation statements)

References 41 publications

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“…Also, the band at 1643 cm −1 is assigned to the carbonyl of the carboxylate group, which is attached to the 8‐hydroxyquinoline moiety . Moreover, the band observed at 1597 cm −1 is assigned to CN vibration . The negative test of acidity on adding NaHCO 3 to L 1 solution suggests that the chloroacetate ion exists as a salt and the hydrogen atom is attached to the nitrogen of 8‐hydroxyquinoline.…”

Section: Resultsmentioning

confidence: 98%

Synthesis of 8‐hydroxyquinolium chloroacetate and synthesis of complexes derived from 8‐hydroxyquinoline, and characterization, density functional theory and biological studies

Mlahi

Afsah

Negm

et al. 2015

Applied Organom Chemis

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8-Hydroxyquinolium chloroacetate (L 1 ) was synthesized and characterized. The results suggest that L 1 loses ethyl chloroacetate ion on coordination at low pH (2-5) and consequently it behaves as 8-hydoxyquinoline (L 2 ). Cu 2+ , Co 2+ , Pt 4+ , Pd 2+ , Au 3+ , Ag + and Nd 3+ complexes derived from L 2 have been synthesized and characterized using spectral, magnetic and thermal measurements. L 2 acts as a neutral bidentate ligand in the case of Cu 2+ , Co 2+ , Pt 4+ , Pd 2+ and Nd 3+ complexes and as a mononegative bidentate ligand in the case of Au 3+ and Ag + complexes. Octahedral geometry is proposed for Cu 2+ , Co 2+ (grey) and Pt 4+ complexes and square-planar for Co 2+ (green), Pd 2+ and Au 3+ complexes. The bond lengths, bond angles, chemical reactivities, binding energies and dipole moments for all compounds were evaluated using density functional theory and molecular electrostatic potential for L 1 . Superoxide dismutase radical scavenger-like activity and cytotoxic activity of the complexes towards HepG2 liver cancer cells has been screened. Cytotoxicity measurements show that Ag + and Pd 2+ complexes have the highest cytotoxic activity while L 1 , Cu 2+ , Co 2+ (grey), Co 2+ (green), Pt 4+ and Nd 3+ complexes have no cytotoxic activity.

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Section: Resultsmentioning

confidence: 98%

Synthesis of 8‐hydroxyquinolium chloroacetate and synthesis of complexes derived from 8‐hydroxyquinoline, and characterization, density functional theory and biological studies

Mlahi

Afsah

Negm

et al. 2015

Applied Organom Chemis

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“…The synthesized compounds were characterized by X-ray crystal structure, fluorescence and electron paramagnetic resonance (EPR) studies. A thermochemical investigation [86] of related metal complexes of 2-acetylpyridine hydrazone has been reported.…”

Section: Issuementioning

confidence: 99%

Interplay of thermochemistry and Structural Chemistry, the journal (volume 19, 2008) and the discipline

et al. 2009

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Coordinating Behaviour of Pyridylhydrazones. Complexes of Rh(III) with Methyl‐2‐Pyridyl and Phenyl‐2‐Pyridyl Hydrazones and N,N′‐Dimethylhydrazones

Kovala‐Demertzi

1993

Bulletin des Soc Chimique

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Mono, bis and tris complexes of Rhodium(II1) with pyridyl hydrazones 2-acetylpyridine hydrazone (APH) and 2-benzoylpyridine hydrazone (BPH) and mono complexes of 2-acetylpyridine dimethylhydrazone (APDMH) and 2-benzoylpyridine dimethyl-hydrazone (BPDMY) have been isolated. The complexes were characterized by elemental analyses conductivity measurements, thermal methods, and spectral (IR, far-IR, electronic, and IH NMR) studies.The ligands appear to coordinate via both pyridine and azomethine atoms. Electronic spectra show that all complexes are octahedral and the bis(1igand) and tris(ligand1 complexes are cis-isomers. INTRODUCTIONNitrogen containing heterocyclic compounds play an important role in several biological processes. Furthermore, their biological activity seems often to depend upon interaction with a metal ion. Interest in the study of hydrazones and their metal complexes has growing because of their physiological activity, coordinative capability and application in analytical chemistry (1-4).Some Rhodium(II1) compounds were found to be anticancer reagents. Among Rh(I1I) complexes with ammonia and organic amine ligands, mer-[Rh(NH3)$131 with leaving grpups in the cis position, was the most active in animal tumor systems and also tetrakis(carboxylato)dirhodium(II) complexes represent a class of compounds with promising activity ( 5 ) . The observed inhibition of DNA synthesis, with this class of compounds, may be due to the blocking of thiolic enzymes (5). Also interest in rhodium coordination chen.istry is stimulated to a great degree by the actual and potential catalytic applications of these compounds ( 6 ) .As part of our systematic investigation on the coordination chemistry of nitrogen heterocyclic compounds with metal ions which might be of interest as anticancer agents, like the platinum metal ions (7) we describe here the preparation and characterization of Rh(II1) complexes with hydrazones and dimethyl-hydrazones of 2-acetyl and 2-benzoylpyridine. The synthesis and properties of the palladium(I1) complexes with hydrazones of 2-acetyl and 2-benzoylpyridine had been reported. Complexes of dimethylhydrazones had not been isolated. Only mono lisand complexes had been

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Variation of product identity as a function of metal ion: ligand reaction ratio, stereochemical studies and thermal investigation of Mn(II), Fe(III), N

Cited by 17 publications

References 41 publications

Synthesis of 8‐hydroxyquinolium chloroacetate and synthesis of complexes derived from 8‐hydroxyquinoline, and characterization, density functional theory and biological studies

Synthesis of 8‐hydroxyquinolium chloroacetate and synthesis of complexes derived from 8‐hydroxyquinoline, and characterization, density functional theory and biological studies

Interplay of thermochemistry and Structural Chemistry, the journal (volume 19, 2008) and the discipline

Coordinating Behaviour of Pyridylhydrazones. Complexes of Rh(III) with Methyl‐2‐Pyridyl and Phenyl‐2‐Pyridyl Hydrazones and N,N′‐Dimethylhydrazones

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