Variation of morphophysiological and genetic demographic traits in children with congenital cleft lip and palate

Курбатова, О. Л.; Vasiliev, Yu. A.; Prudnikova, A. S.; Pobedonostseva, E. Yu.; Uchaeva, V. S.; Verapatvelyan, A. F.; Udina, I. G.

doi:10.1134/s1022795411110111

Cited by 2 publications

(3 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Second, due to the small sample size and the low exposure rates of some of the investigated factors, some common important risk factors were not included in the prediction model, such as maternal age, folic acid intake, history of infection during pregnancy, mothers’ abnormal reproductive history, medication use during pregnancy, maternal stressful events during pregnancy, tobacco, and alcohol. Many of the published papers show conflicting results on the relationship between maternal age and NSCL/P [10, 12, 41]. The effect of folic acid on NSCL/P has generated debate in previous studies [28, 41, 42].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, most studies have focused on the identification of risk factors of NSCL/P. Many epidemiological studies have confirmed that maternal age [10–12], maternal educational level [2, 13], family income [13, 14], abnormal reproductive histories [15], family history [14–16], history of infection during pregnancy [17], medication use during pregnancy [18, 19], ambient environment pollution [20], parental occupational hazards exposure [21–23], maternal nutrient intake [23–26], and maternal lifestyle factors (alcohol drinking, smoking) [27–29] are associated with NSCL/P. However, an individual risk prediction tool for NSCL/P has not been reported.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Luo

et al. 2016

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

BackgroundA risk prediction model of non-syndromic cleft lip with or without cleft palate (NSCL/P) was established by a discriminant analysis to predict the individual risk of NSCL/P in pregnant women.MethodsA hospital-based case–control study was conducted with 113 cases of NSCL/P and 226 controls without NSCL/P. The cases and the controls were obtained from 52 birth defects’ surveillance hospitals in Hunan Province, China. A questionnaire was administered in person to collect the variables relevant to NSCL/P by face to face interviews. Logistic regression models were used to analyze the influencing factors of NSCL/P, and a stepwise Fisher discriminant analysis was subsequently used to construct the prediction model.ResultsIn the univariate analysis, 13 influencing factors were related to NSCL/P, of which the following 8 influencing factors as predictors determined the discriminant prediction model: family income, maternal occupational hazards exposure, premarital medical examination, housing renovation, milk/soymilk intake in the first trimester of pregnancy, paternal occupational hazards exposure, paternal strong tea drinking, and family history of NSCL/P. The model had statistical significance (lambda = 0.772, chi-square = 86.044, df = 8, P < 0.001). Self-verification showed that 83.8 % of the participants were correctly predicted to be NSCL/P cases or controls with a sensitivity of 74.3 % and a specificity of 88.5 %. The area under the receiver operating characteristic curve (AUC) was 0.846.ConclusionsThe prediction model that was established using the risk factors of NSCL/P can be useful for predicting the risk of NSCL/P. Further research is needed to improve the model, and confirm the validity and reliability of the model.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Luo

et al. 2016

BMC Pregnancy Childbirth

View full text Add to dashboard Cite

show abstract

“…Age at delivery: We classified maternal age at delivery into six groups (<20, 20–24, 25–29, 30–34, 35–39, >39 years). Mother's age at delivery has been found to be a risk factor for giving birth to a child with an OFC; 45 however, this risk seems to differ with cleft type. 46 Mother's age may also affect the risk for the offspring developing poor psychological health.…”

Section: Methodsmentioning

confidence: 96%

Psychotropic drug use in adolescents born with an orofacial cleft: a population-based study

et al. 2015

View full text Add to dashboard Cite

ObjectivesBeing born with an orofacial cleft (OFC) can, due to an incomplete closure of the lip and/or palate, convey a deviant speech and/or deviant facial aesthetics, which may in turn increase the risk for poor psychological health later in life. Previous investigations have been based on small samples and self-reports, not distinguishing between the three different types of OFC: cleft lip (CL), CL and palate (CLP) and cleft palate only (CPO). We present a large population-based study, considering psychotropic drug use as a proxy for poor psychological health and distinguishing between three different types of OFC.Design and methodsUsing the Swedish Medical Birth Register, and linking to it the Swedish Prescribed Drug Register, the National Mortality Register, the Emigration Register and the National Inpatient Register, we identified all singletons born to native mothers in Sweden between 1987 and 1993, alive and residing in Sweden at the end of an 18-year follow-up period (N=626 109). We compared psychotropic drug use among individuals with and without OFC during the individuals’ adolescence (2005–2008) by multiple logistic regressions, using ORs with 95% CIs.ResultsWhen adjusted for potential confounders, having a CL (OR=1.63, 95% CI 1.08 to 2.46) or a CPO (OR=1.54, 95% CI 1.18 to 2.01) increased the risk of psychotropic drug use. Results were not significant regarding adolescents who had a CLP (OR=1.21, 95% CI 0.81 to 1.80).ConclusionsBeing born with a CL or a CPO increases the risk for psychotropic drug use in adolescence, but not for adolescents born with a CLP. Our findings suggest that, since the three OFC types are associated with different long-term risks of poor psychological health, the three groups should be studied separately concerning long-term psychosocial consequences.

show abstract

Variation of morphophysiological and genetic demographic traits in children with congenital cleft lip and palate

Cited by 2 publications

References 8 publications

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

A discriminant analysis prediction model of non-syndromic cleft lip with or without cleft palate based on risk factors

Psychotropic drug use in adolescents born with an orofacial cleft: a population-based study

Contact Info

Product

Resources

About