Variation of CYP2C9 Gene and Glycemic Control in Diabetic Patients: A Literature Review

Abstract

The prevalence of Diabetes Mellitus Type 2 (DMT2) is continuing to increase worldwide. The variety of responses to the oral antidiabetic is influenced by several factors, including genetics, physiology, pathophysiology and the environment. Genetic factors are estimated to contribute 15-30% to differences in metabolism and drug response between individuals. The purpose of this study was to determine the variation of the CYP2C9 gene in DMT2 patients and its association with glycemic control. The method used in this research was literature review. Keywords used for collecting the articles were "CYP2C9, diabetes mellitus, type 2, oral antidiabetic". Article search was conducted on Google Scholar, PubMed and several international journal providers. The inclusion criteria were articles published in the last 20 years that addressed the variance and polymorphism of CYP2C9 in DMT2 patients and could be reviewed in full text, including national and international journals. The exclusion criteria in this research were articles that are not original articles. The analysis in this study was performed by describing the qualitative and quantitative results of the journal studies reviewed. We found 13 articles that met the inclusion criteria. The DMT2 patients included in the study were from India,