Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer

Park, Sunmin; Rim, Chai Hong; Yoon, Won Sup

doi:10.1186/s13014-021-01806-5

Cited by 3 publications

(2 citation statements)

References 30 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CBCT‐guided radiotherapy has the potential to reduce setup errors, improve radiotherapy accuracy, minimize the external margin of the PTV, and decrease the dose delivered to the OARs. 19 , 20 , 21 However, the accuracy of image registration is influenced by various factors, including the registration algorithm, 22 the region of interest, 10 , 23 and the evaluation criteria. 24 Richter et al 22 reported that gray‐level registration has higher accuracy registration than bony registration.…”

Section: Discussionmentioning

confidence: 99%

A novel evaluation model of image registration for cone‐beam computed tomography guided lung cancer radiotherapy

Liu,

Chen,

Fang

et al. 2024

Thoracic Cancer

View full text Add to dashboard Cite

BackgroundThe aim of the study was to establish a weighted comprehensive evaluation model (WCEM) of image registration for cone‐beam computed tomography (CBCT) guided lung cancer radiotherapy that considers the geometric accuracy of gross target volume (GTV) and organs at risk (OARs), and assess the registration accuracy of different image registration methods to provide clinical references.MethodsThe planning CT and CBCT images of 20 lung cancer patients were registered using diverse algorithms (bony and grayscale) and regions of interest (target, ipsilateral, and body). We compared the coverage ratio (CR) of the planning target volume (PTVCT) to GTVCBCT, as well as the dice similarity coefficient (DSC) of the GTV and OARs, considering the treatment position across various registration methods. Furthermore, we developed a mathematical model to assess registration results comprehensively. This model was evaluated and validated using CRFs across four automatic registration methods.ResultsThe grayscale registration method, coupled with the registration of the ipsilateral structure, exhibited the highest level of automatic registration accuracy, the DSC were 0.87 ± 0.09 (GTV), 0.71 ± 0.09 (esophagus), 0.74 ± 0.09 (spinal cord), and 0.91 ± 0.05 (heart), respectively. Our proposed WCEM proved to be both practical and effective. The results clearly indicated that the grayscale registration method, when applied to the ipsilateral structure, achieved the highest CRF score. The average CRF scores, excellent rates, good rate and qualification rates were 58 ± 26, 40%, 75%, and 85%, respectively.ConclusionsThis study successfully developed a clinically relevant weighted evaluation model for CBCT‐guided lung cancer radiotherapy. Validation confirmed the grayscale method's optimal performance in ipsilateral structure registration.

show abstract

Section: Discussionmentioning

confidence: 99%

A novel evaluation model of image registration for cone‐beam computed tomography guided lung cancer radiotherapy

Liu,

Chen,

Fang

et al. 2024

Thoracic Cancer

View full text Add to dashboard Cite

show abstract

“…Extensive studies have focused on the impact of translational setup errors and roll or yaw rotations on the dose distribution in breast cancer radiotherapy. 12,24,25 Therefore, the rotational setup errors in 3 directions were simulated simultaneously in this study. In dosimetry comparisons of the PTV, a 5% change in the dosimetry was judged as acceptable variation.…”

Section: Dosimetry Variations For the Breast Target And Oars With Or ...mentioning

confidence: 99%

In Silico Studies of the Impact of Rotational Errors on Translation Shifts and Dose Distribution in Image-Guided Radiotherapy

Cui

Qiu

et al. 2023

Technol Cancer Res Treat

View full text Add to dashboard Cite

Objective: To compare the 6-dimensional errors of different immobilization devices and body regions based on 3-dimensional cone beam computed tomography for image-guided radiotherapy and to further quantitatively evaluate the impact of rotational corrections on translational shifts and dose distribution based on anthropomorphic phantoms. Materials and Methods: Two hundred ninety patients with cone beam computed tomographies from 3835 fractions were retrospectively analyzed for brain, head & neck, chest, abdomen, pelvis, and breast cases. A phantom experiment was conducted to investigate the impact of rotational errors on translational shifts using cone beam computed tomography and the registration system. For the dosimetry study, pitch rotations were simulated by adjusting the breast bracket by ±2.5°. Roll and yaw rotations were simulated by rotating the gantry and couch in the planning system by ±3.0°, respectively. The original plan for the breast region was designed in the computed tomography image space without rotation. With the same planning parameters, the original plan was transplanted into the image space with different rotations for dose recalculation. The effect of these errors on the breast target and organs at risk was assessed by dose-volume histograms. Results: Most of the mean rotational errors in the breast region were >1°. A single uncorrected yaw of 3° caused a change of 2.9 mm in longitudinal translation. A phantom study for the breast region demonstrated that when the pitch rotations were −2.5° and 2.5° and roll and yaw were both 3°, the reductions in the planning target volumes-V50 Gy were 20.07% and 29.58% of the original values, respectively. When the pitch rotation was +2.5°, the left lung V5 Gy and heart Dmean were 7.49% and 165.76 Gy larger, respectively, than the original values. Conclusions: Uncorrected rotations may cause changes in the values and directions of translational shifts. Rotational corrections may improve the patient setup and dose distribution accuracy.

show abstract

Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer

Yang

Zhang

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

ObjectivesModern breast cancer techniques, such as the deep inspiration breath-hold (DIBH) technique has been applied for left-sided breast cancer. Whether the DIBH regimen is the optimal solution for left-sided breast cancer remains unclear. This meta-analysis aims to elucidate the differences of DIBH and free-breathing (FB) for patients receiving radiotherapy for left-sided breast cancer and provide a practical reference for clinical practice.MethodsRelevant research available on PubMed, Embase, Cochrane Library, and the Web of Science published before November 30, 2021 was independently and systematically examined by two investigators. Data were extracted from eligible studies for assessing their qualities and calculating the standardized mean difference (SMD) and 95% confidence intervals (CIs) using Review Manager software 5.4 (RevMan 5.4).ResultsForty-one studies with a total of 3599 left-sided breast cancer patients were included in the meta-analysis. Compared with FB, DIBH reduced heart dose (Dmean, Dmax, V30, V10, V5), left anterior descending branch (LAD) dose (Dmean, Dmax), ipsilateral lung dose (Dmean, V20, V10, V5), and heart volume significantly. Lung volume increased greatly, and a statistically significant difference. For contralateral breast mean dose, DIBH has no obvious advantage over FB. The funnel plot suggested this study has no significant publication bias.ConclusionsAlthough DIBH has no obvious advantage over FB in contralateral breast mean dose, it can significantly reduce heart dose, LAD dose, ipsilateral lung dose, and heart volume. Conversely, it can remarkably increase the ipsilateral lung volume. This study suggests that soon DIBH could be more widely utilized in clinical practice because of its excellent dosimetric performance.

show abstract

Variation of heart and lung radiation doses according to setup uncertainty in left breast cancer

Cited by 3 publications

References 30 publications

A novel evaluation model of image registration for cone‐beam computed tomography guided lung cancer radiotherapy

A novel evaluation model of image registration for cone‐beam computed tomography guided lung cancer radiotherapy

In Silico Studies of the Impact of Rotational Errors on Translation Shifts and Dose Distribution in Image-Guided Radiotherapy

Comparison of Deep Inspiration Breath Hold Versus Free Breathing in Radiotherapy for Left Sided Breast Cancer

Contact Info

Product

Resources

About