Variation of different metabolites and heavy metals in Oryza sativa L., related to chronic kidney disease of unknown etiology in Sri Lanka

Fernando, T. D.; Jayawardena, B.; Arachchige, Yohan L. N. Mathota

doi:10.1016/j.chemosphere.2020.125836

Cited by 19 publications

(5 citation statements)

References 35 publications

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“…Phosphate fertilizers as well include heavy metals and arsenic (Jayasumana et al 2015a , b , c , d ). In Sri Lanka, some reports the presence of Pb and Cr in rice and Cd and Cr in water (Fernando et al 2018 ; 2020 ). A limited study in 2012–2013 carried out in the North Central Province, Sri Lanka on the presence of heavy metals and trace elements biological samples (blood and hair) and environmental samples (rice, freshwater fish, soil and drinking water) revealed low-level exposure of Pb, Cd, and Hg of biological samples and exceeding concentrations of As, Cr, Cu, Fe, Hg, Mn, Ni, Pb and Se in soil as compared to mean background US criteria, while the concentrations of F, Fe, Mn, Na and Pb in drinking water samples exceeded the values recommended by the WHO.…”

Section: Resultsmentioning

confidence: 99%

Rising of a global silent killer: critical analysis of chronic kidney disease of uncertain aetiology (CKDu) worldwide and mitigation steps

Priyadarshani

Namor

Silva

2022

Environ Geochem Health

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Chronic kidney disease of uncertain aetiology (CKDu) is an advanced version of chronic kidney disease (CKD) which bears a high burden on the world health economy. More than 200 articles were analysed to understand the disease responsible for more than 30,000 deaths per year. CKDu is a non-communicable occupational disease that has a progressive deterioration of the kidney in the absence of CKD risk factors such as hypertension, diabetes and glomerulonephritis, while the diagnosis is only possible at the later stages when kidney function is no longer effective. Published evidence for the existence of CKDu was found for around 35 countries. This is a growing health issue in Asia, Central America, Africa and Middle East with identified hot spots. Despite many research studies over decades, the exact root causes are still uncertain. Six main suspected causative factors are identified. Those are heat stress, strenuous labour, dehydration, use of agrochemicals, exposure to heavy metals and the use of polluted water and agricultural lands. This review summarizes four key areas which are CKDu and its general medical background, worldwide prevalence, suspected causative factors and potential circumventing steps to mitigate against CKDu. The importance of further studies addressing early detection and surveillance methods, contribution of nephrotoxins in environmental health, soil chemistry on transporting nephrotoxins, geological parameters which influence the prevalence of the disease and other related sectors to overcome the mysterious nature is highlighted. Mitigation steps to lessen the burden of CKDu are also identified.

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Section: Resultsmentioning

confidence: 99%

Rising of a global silent killer: critical analysis of chronic kidney disease of uncertain aetiology (CKDu) worldwide and mitigation steps

Priyadarshani

Namor

Silva

2022

Environ Geochem Health

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“…Further research has shown that polyphenol-rich foods, including Indian plums [ 124 ], radishes [ 125 , 126 ], green algae [ 127 ], acacia gum [ 128 ], basil leaves [ 129 , 130 ], essential oils [ 131 ], coffee and olive oils [ 132 ], and red palm oil [ 133 , 134 ], can ameliorate kidney damage induced by various toxins. Moreover, phenolic compounds have shown promising results in preventing further heavy-metal-induced kidney injury [ 135 , 136 , 137 ]. While research suggests that some polyphenols might hold promise in safeguarding the kidneys from nephrotoxic damage, further studies are warranted to confirm their efficacy and safety in human subjects.…”

Section: Discussionmentioning

confidence: 99%

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Baptista,

Paié-Ribeiro,

Almeida

et al. 2024

Molecules

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Chronic kidney disease (CKD) presents a formidable global health concern, affecting one in six adults over 25. This review explores the potential of phenolic compounds in managing CKD and its complications. By examining the existing research, we highlight their diverse biological activities and potential to combat CKD-related issues. We analyze the nutritional benefits, bioavailability, and safety profile of these compounds. While the clinical evidence is promising, preclinical studies offer valuable insights into underlying mechanisms, optimal dosages, and potential side effects. Further research is crucial to validate the therapeutic efficacy of phenolic compounds for CKD. We advocate for continued exploration of their innovative applications in food, pharmaceuticals, and nutraceuticals. This review aims to catalyze the scientific community's efforts to leverage phenolic compounds against CKD-related challenges.

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“…Protein content was determined using a BCA Protein Assay Kit (TransGen Biotech, Beijing, China). Free amino acid content was determined according to the colorimetric method of nihydrin determination 33 . Absorbance (570 nm) of the samples was measured with a spectrophotometer (model 340, Sequoia‐Turner Co, Taiwan).…”

Section: Methodsmentioning

confidence: 99%

“…Free amino acid content was determined according to the colorimetric method of nihydrin determination. 33 Absorbance (570 nm) of the samples was measured with a spectrophotometer (model 340, Sequoia-Turner Co, Taiwan). Free amino acid content was determined spectrophotometrically at a wavelength of 570 nm.…”

Section: Determination In Nutritional Components Taste Value and Rice...mentioning

confidence: 99%

Physiological and transcriptomic analysis reveal the regulatory mechanism underlying grain quality improvement induced by rice ratooning

et al. 2022

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BACKGROUND Ratoon rice cropping has been introduced for increased rice production in southern China and, as a result, has been becoming increasingly popular. However, only a few studies have addressed the regulatory mechanism underlying grain quality improvement induced by rice ratooning. RESULTS In this study, parameters of rice quality, including head rice yield, chalky grain percentage, grain chalkiness degree, hardness and taste value, were shown to be much improved in the ratooning season rice as compared to its counterparts main and late cropping season rice, indicating that such an improvement was irrespective of seasonal effects. In addition, the nutritional components of grains varied greatly between main‐cropping season rice, ratooning season rice and late‐cropping season rice and displayed a significant correlation with rice quality. Finally, the regulatory mechanism underlying rice quality improvement revealed that gibberellin‐dominated regulation and plant hormone signal transduction jointly contributed to a decrease in formation of chalky grains. CONCLUSION This work improves our knowledge on rice quality improvement under rice ratooning, particularly on the regulatory mechanism of plant hormones. © 2022 Society of Chemical Industry.

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Variation of different metabolites and heavy metals in Oryza sativa L., related to chronic kidney disease of unknown etiology in Sri Lanka

Cited by 19 publications

References 35 publications

Rising of a global silent killer: critical analysis of chronic kidney disease of uncertain aetiology (CKDu) worldwide and mitigation steps

Rising of a global silent killer: critical analysis of chronic kidney disease of uncertain aetiology (CKDu) worldwide and mitigation steps

Exploring the Role of Phenolic Compounds in Chronic Kidney Disease: A Systematic Review

Physiological and transcriptomic analysis reveal the regulatory mechanism underlying grain quality improvement induced by rice ratooning

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