Variation of DaTSCAN quantification between different gamma camera types

Abstract

The transfer of a DaTSCAN database between camera types is feasible, but ideally all data would be acquired on a single camera type and phantom data used to normalize the database accordingly.

The Role of CT-Based Attenuation Correction and Collimator Blurring Correction in Striatal Spect Quantification

“…All SPECT images were transformed to the same space by fitting to a FP-CIT template using BRASS software (Hermes Medical Solutions, Sweden) [28, 29]. This was done by applying a filter (Butterworth, order 5, cut off 0.9 cm −1 ) to the unfiltered SPECT image of each patient obtained using nonuniform attenuation correction and correction for collimator blurring using a variable point spread function.…”

Discrimination between parkinsonian syndrome and essential tremor using artificial neural network classification of quantified DaTSCAN data

“…An input to document the side of the tremor, and outputs to document the stage of the disease may also be considered. There is a possibility of variation in the results of the quantitative analysis of data obtained from different gamma camera types, although this has not been shown to be statistically significant in the type of analysis used here [15]. There may also be the possibility of variation among different centres with the same camera type.…”

“…1). This method is similar to the crescent analysis [18] provided in the QuantiSPECT (GE Healthcare) computer program [15]. The simplest method of ROI construction, i.e., completely freehand, was used.…”

“…Previously reported analyses [15,16] were undertaken. SOR involved calculating the ratio of the c/p in each striatum to the c/p in the occipital cortex area.…”

“…It is most often based on the ratio of the activity in the striatum, caudate nucleus or putamen to that in the occipital cortex [2][3][4][5][6][8][9][10][11][12][13][14][15][16][17]; the occipital cortex being used because it is devoid of dopaminergic receptors [18] but receives an equal supply of tracer [1]. Discrimination between parkinsonian syndromes and essential tremor has been documented [3,8,18], as has statistically significant putamen uptake asymmetry [2].…”