Variation of Anesthetic Sedation Requirements in Children Undergoing Auditory Brainstem Response (ABR) Test: A Retrospective Cross-sectional Study

Abstract

Background: Varying sedation requirements may impact anesthetic management and patient outcome. Children with brain disorders may have different requirements than unaffected children. The auditory brainstem response (ABR) test is used to estimate hearing sensitivity and as a diagnostic tool to evaluate autism.

Dexmedetomidine and propofol sedation requirements in an autistic rat model

“…Autistic rats given both sedatives (propofol and dexmedetomidine) needed a significantly longer time to achieve LORR and recovered their reflex more quickly than did the control rats. These results are consistent with those of previous clinical observations [7].…”

“…However, few controlled studies [1,6], have been conducted on this cohort of patients. Recently, our research group observed a variation in propofol sedation requirements among autistic children undergoing the auditory brainstem response test when compared with others with delayed language development [7]. However, observational studies are vulnerable to confounding.…”