Variation of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 levels in human plasma obtained from 758 Japanese healthy subjects.

Kobayashi, Tadashi; Okano, Toshio; Shida, Sumiko; Okada, Kaoru; Suginohara, Toshie; Nakao, Hideto; Kuroda, Eizo; Kodama, Satoru; Matsuo, Tamotsu

doi:10.3177/jnsv.29.271

Cited by 50 publications

(23 citation statements)

References 13 publications

(1 reference statement)

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“…Although several authors have reported higher serum levels of 25(OH)D in normal men than in normal women [17,18], data has not been available for patients with Graves' disease. In the present study, female Graves' patients had lower serum 25(OH)D levels than did their male counterparts.…”

Section: Laboratory Testsmentioning

confidence: 99%

“…3) supports our hypothesis. [17,[21][22][23], children [22], and elderly subjects [24], indicating an essential role of direct UV exposure in maintaining normal 25(OH)D levels. We also found seasonal variations in 25(OH)D concentrations in patients with Graves' disease; high levels were observed during summer and low levels were observed during winter (Fig.…”

Section: Laboratory Testsmentioning

confidence: 99%

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High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

et al. 2001

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Abstract.We reported previously that vitamin D deficiency is a causal mechanism of postoperative tetany in patients with Graves' disease. The aim of the present study was to determine the prevalence of vitamin D deficiency by reviewing serum 25(OH)D levels in 208 patients with Graves' disease (146 women, 62 men) during a 1 year period. Serum 25(OH)D levels were significantly lower (p <0.001) in female Graves' patients (31.8± 13.3 nmol/1) than in male patients (41.3 ± 15.0 nmol/1). Vitamin D deficiency (defined as a serum 25(OH)D value below 25 nmol/l) was found in 40% of female patients and in 18% of male patients (p<0.005).There was a significant seasonal variation in the 25(OH)D concentrations in female patients [amplitude 6.38 (95% CI, 5.42-7.56)], with values below 25 nmol/1 found in 58% of female patients during the winter months. There were significant (p <0.001) differences in serum 25(OH)D levels between age groups in the female patients.The concentrations were lowest in patients in their twenties (25.1 ±8.2 nmol/1) and highest in patients in their fifties and sixties (43.2± 13.7 nmol/1). Serum 25(OH)D concentrations might be monitored in patients with Graves' disease during antithyroid drug therapy, and vitamin D and/or calcium supplements are recommended for patients with vitamin D deficiency.

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Section: Laboratory Testsmentioning

confidence: 99%

Section: Laboratory Testsmentioning

confidence: 99%

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

et al. 2001

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“…Hiroaki ITOH 1 * , Ippei MORI 1, 2 , Yuki MATSUMOTO 1 , Syou MAKI 1 and Yasutaka OGAWA 1 25-Hydroxyvitamin D (25OHD), a major component of circulating vitamin D metabolites whose biological half-life in blood (2-5 wk in normal subjects) [10][11][12][13][14] is substantially longer than that of vitamin D itself (24 h) 10) , is commonly used as an indicator of individuals' vitamin D status 15) . Exposure to solar ultraviolet (UV) B irradiation changes 7-dehydrocholesterol to previtamin D by photosynthesis in the skin.…”

Section: Vitamin D Deficiency and Seasonal And Inter-day Variation Inmentioning

confidence: 99%

Vitamin D Deficiency and Seasonal and Inter-day Variation in Circulating 25-hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers: A Longitudinal Study

et al. 2011

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D (p=0.62). Notably, nearly all measured 25OHD levels in February were lower than the reference value of 20 ng/ml. Our study identified the occurrence of seasonal variation in circulating 25OHD and intact PTH levels, even after accounting for inter-day variability, and hypovitaminosis D in wintertime in indoor daytime male workers in Japan. Due to this variability, single spot measurements of 25OHD may lead to misjudgment of workers' vitamin D status.

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“…Serum levels of 25OHD (ng/mL) and 1,25OHD (pg/mL) were measured at SRL Inc. (Hachioji, Tokyo, Japan) as described previously (15,16). In each case, blood samples were collected in the operating room prior to anesthesia induction to avoid the hemodilution effect of intravenous fl uid infusion (17) and stored at Ϫ80˚C until measurements.…”

Section: Methodsmentioning

confidence: 99%

A Cross-Sectional Study of the Association between Circulating 25-Hydroxyvitamin D Levels and Predicted Operative Mortality of Patients with Cardiovascular Disease

Tsutsumi

Sanui

Shimojima

et al. 2012

J Nutr Sci Vitaminol

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327Vitamin D is mainly synthesized through exposure to sunlight and ingested from the diet and/or through supplements, which are metabolized to the major circulating form of vitamin D, 25-hydroxyvitamin D (25OHD) in the liver. 25OHD is metabolized in the kidneys by 25-hydroxyvitamin D-1␣-hydroxylase (1␣OHase) to its active form, 1,25-dihyroxyvitamin D (1,25OHD); serum levels of 1,25OHD are tightly regulated in the range of 20 to 60 pg/mL by parathyroid hormone (PTH) as well as calcium (Ca) and phosphate levels (1). Secretion of 1,25OHD into the serum facilitates not only intestinal Ca and phosphate absorption, but also bone calcifi cation. Defi ciency of 1,25OHD is known to cause rickets, osteopenia, osteoporosis, and osteomalacia, and to simultaneously increase the risk of fracture.In addition to these bone diseases, recent epidemiologic evidence suggests that 25OHD defi ciency, but not 1,25OHD defi ciency, is associated with an increased risk of many chronic diseases including cardiovascular disease (CVD), various cancers, and infectious diseases (2). In the Framingham Offspring Study, 25OHD defi ciency was associated with incident CVD (3). The risk for CVD may be associated with ubiquitous expression of both 1␣OHase and vitamin D receptor (VDR) in a variety of cell types including vascular smooth muscle cells, endothelial cells, and cardiomyocytes (4). Various experimental studies also suggest that vitamin D supplements provide cardiovascular protection including anti-atherosclerotic, anti-infl ammatory, and direct cardio-protective actions, as well as benefi cial effects on classic cardiovascular risk factors and suppression of PTH levels (5). Observational studies and meta-analyses of randomized controlled trials indicate that vitamin D supplements may reduce CVD-related disease and all-cause mortality (6), although a cause and effect relationship is still controversial (7). Of critically ill patients, similarly, Lee et al. identifi ed the possibility of a relationship between low levels of 25OHD, and high morbidity and mortality Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo 105-8461, Japan 3 Department of Anesthesiology, Intensive Care Unit, Jichi Medical University Saitama Medical Center, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama 330-8503, Japan (Received April 6, 2012) Summary Recent studies have suggested that low levels of 25-hydroxyvitamin D (25OHD) are associated with cardiovascular risks in medical patients. However, these associations have not been well documented in high risk surgical patients. We hypothesized that serum 25OHD, 1,25-dihydroxyvitamin D (1,25OHD) would be associated with the cardiac operative risk stratifi cation score. The study was conducted with a cross-sectional design at a single academic medical center in Japan. Two hundred fi ve adult patients scheduled for major cardiovascular surgery were included consecutively. Cardiac operative risk was evaluated with the European System for Cardiac Operative Risk Evaluation (EuroSCORE) scoring system. Correlations betwe...

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Variation of 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 levels in human plasma obtained from 758 Japanese healthy subjects.

Abstract: SummaryPlasma levels of 25-hydroxyvitamin D3 (25-OH-D3) and 25-hydroxyvitamin D2 (25-OH-

Cited by 50 publications

References 13 publications

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

High Prevalence of Vitamin D Deficiency in Japanese Female Patients with Graves' Disease.

Vitamin D Deficiency and Seasonal and Inter-day Variation in Circulating 25-hydroxyvitamin D and Parathyroid Hormone Levels in Indoor Daytime Workers: A Longitudinal Study

A Cross-Sectional Study of the Association between Circulating 25-Hydroxyvitamin D Levels and Predicted Operative Mortality of Patients with Cardiovascular Disease

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