Variation of 24-Hour Intraocular Pressure in Healthy Individuals

Liu, John H.K.; Sit, Arthur J.; Weinreb, Robert N.

doi:10.1016/j.ophtha.2005.05.007

Cited by 108 publications

(102 citation statements)

References 22 publications

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“…In contrast to other studies [1,3,4], we could find a significantly lower IOP max (12%) in the nocturnal compared to the diurnal preoperative IOP curve. An explanation for that finding might be that some of our patients had their nocturnal measurements in a sitting position.…”

Section: Discussioncontrasting

confidence: 99%

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Diurnal and Nocturnal Intraocular Pressure Fluctuations after Trabeculectomy

Klink

Praetorius²,

Leippi

et al. 2011

Ophthalmologica

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Purpose: The aim of this study was to compare diurnal and nocturnal intraocular pressure (IOP) fluctuations before and after trabeculectomy, and to evaluate the potential of trabeculectomy to even out IOP peaks. Materials and Methods: Retrospectively, 35 diurnal and nocturnal IOP curves of patients (35 eyes) who underwent trabeculectomy were analyzed. Diurnal and nocturnal IOP profiles were recorded from 06:00 to 23:59 and 00:00 to 06:00, respectively. Follow-up was at least 300 days. Two criteria for success were defined: (1) IOP ≤21 mm Hg and at least a 20% IOP reduction from baseline; (2) <18 mm Hg without medication. Results: The preoperative maximum diurnal and nocturnal IOP (IOP_max) were 26.5 ± 5.9 and 23.4 ± 5.2 mm Hg, respectively. The postoperative diurnal and nocturnal IOP_max were 16 ± 4.4 and 16 ± 5.4 mm Hg, respectively. Pre- to postoperative IOP reductions were statistically different (day 40% and night 32%; p < 0.001). Diurnal fluctuation was reduced significantly from 12.1 ± 4.2 mm Hg preoperatively to 5.6 ± 2.2 mm Hg postoperatively (reduction of 54%), and nocturnal fluctuation from 7.1 ± 4.5 to 3.9 ± 4.1 mm Hg (reduction of 46%, statistically insignificant due to large SD), respectively. Success criteria 1 and 2 were achieved in 71 and 54% of patients at daytime and in 63 and 57% at nighttime (no statistically significant difference detectable). Follow-up was 2.1 ± 1.7 years. Conclusions: Trabeculectomy achieves a leveling of IOP_max in the diurnal-nocturnal comparison. The preoperative fluctuations could be nearly bisected. Relating to the success criteria, the statistical analysis did not reveal a difference in the diurnal-nocturnal comparison.

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Section: Discussioncontrasting

confidence: 99%

“…Intraocular pressure (IOP) follows a circadian rhythm in healthy eyes [1]. Most of the available studies have concentrated on the diurnal IOP fluctuations.…”

Section: Introductionmentioning

confidence: 99%

Diurnal and Nocturnal Intraocular Pressure Fluctuations after Trabeculectomy

Klink

Praetorius²,

Leippi

et al. 2011

Ophthalmologica

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“…10 Compared with the upright posture, IOP has been shown to increase in the horizontal postures (supine, [11][12][13][14][15][16][17] prone, or lateral decubitus [18][19][20][21][22][23][24] ) in healthy and glaucomatous eyes. Such posture-induced IOP rise has been associated with progression of glaucomatous damage.…”

Section: Introductionmentioning

confidence: 99%

Effects of head elevation on intraocular pressure in healthy subjects: raising bed head vs using multiple pillows

et al. 2014

Eye

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Purpose To evaluate the effects of different methods of head elevation on intraocular pressure (IOP) in healthy young subjects. Methods Twenty-four healthy young Korean subjects were included in this prospective observational study. The IOP measurements were taken with the subjects in the sitting position and in the supine positions with the head flat and 301 up using two different methods: (1) raising the bed head and (2) using multiple pillows. IOP was measured using Tonopen AVIA in both eyes 10 min after assuming each position in a randomized sequence. The Wilcoxon signed-rank test was used to compare the IOP by changing the methods of head elevation. Results Mean IOP of both eyes when sitting was lower than that measured in the supine position with head flat (P ¼ 0.001). Compared with that measured in the supine position with head flat, the mean IOP was lower when measured in the supine position with the head kept 30 1 up by bed head elevation (P ¼ 0.001), whereas the mean IOP was not significantly different when measured in the supine position with the head elevated using multiple pillows (right eye, P ¼ 0.061; left eye, P ¼ 0.089). Conclusion In normal subjects, IOP was lower when measured in the supine position with the head kept up by the bed head elevation compared with that measured when lying flat. However, such head-up positioninduced IOP reduction was not found when the head was kept up using multiple pillows. These findings suggest that elevating the head using multiple pillows may not help to reduce IOP in the supine posture.

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“…Further to that, there are few reports on how IOP and BP fluctuate at different time-points during the 24hour period [34, 35] and therefore we do not know the result of IOP and BP fluctuation on PP. In a recent report by Kida T et al .…”

Section: Pp: a Tricky Variable With Regards To Iop And Bpmentioning

confidence: 98%

Weighing in Ocular Perfusion Pressure in Managing Glaucoma

Topouzis

Founti²

2009

TOOPHTJ

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The role of vascular risk factors in glaucoma is increasingly being supported by the literature, with the association between low ocular perfusion pressure (PP) and glaucoma being the most consistent result. However, we need to be cautious when interpreting these results and consider all possible confounders in the observed associations. While we assess PP through its principal components, the weight of intraocular pressure (IOP) and blood pressure (BP) in the PP equation remains unknown. Also, the role of PP in glaucoma needs to be elucidated with regards to IOP and BP fluctuation during the 24hour period and the effect of IOP-lowering and BP-lowering treatment. The complexity of the interaction of PP with other potential risk factors for glaucoma means that PP cannot be currently considered in the assessment of an individual patient. The role of PP in glaucoma warrants further research and randomized clinical trials assessing PP should include vision and/or structure preservation as end-points and ideally address all of the above issues.

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Variation of 24-Hour Intraocular Pressure in Healthy Individuals

Cited by 108 publications

References 22 publications

Diurnal and Nocturnal Intraocular Pressure Fluctuations after Trabeculectomy

Diurnal and Nocturnal Intraocular Pressure Fluctuations after Trabeculectomy

Effects of head elevation on intraocular pressure in healthy subjects: raising bed head vs using multiple pillows

Weighing in Ocular Perfusion Pressure in Managing Glaucoma

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