Variation in tumor doubling time in patients with pulmonary metastatic disease

Joseph, William L.; Morton, Donald L.; Adkins, Paul C.

doi:10.1002/jso.2930030207

Cited by 41 publications

(25 citation statements)

References 9 publications

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“…Thus differences in T2 explained only one third of the variation of the survival times from detection of metastatic disease. T2 has previously been found to correlate well with the prognosis in both sarcomas (Joseph et al, 1971) and lung tumours of other histology and in sarcoma patients after resection of lung metastases (Spratt & Spratt, 1964). When tested as a prognostic factor for survival with a conventional Cox model T2 did, however, not reach statistical significance in this study, possibly because of the small sample size.…”

Section: Resultscontrasting

confidence: 53%

“…Sarcomas are especially well suited for this kind of studies due to their propensity for lung metastases and the often well circumscribed easily measurable lesions. Tumour doubling time measured from chest x-rays has been shown to be an important prognostic factor for overall survival in both primary and secondary lung tumours (Joseph et al, 1971;Spratt & Spratt, 1964). In recent years the development of novel methods for the study of tumour proliferation by flow cytometry and immunohistochemistry have stimulated a renewed interest in the measurement of growth characteristics of human tumours.…”

mentioning

confidence: 99%

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Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma

Blomqvist

Wıklund²,

Tarkkanen³

et al. 1993

Br J Cancer

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The volume doubling time (T2) of 52 lung metastases in 21 patients was calculated from measurements done on plain chest radiographs. Follow-up times ranged from 14 to 819 days. The measurements were fairly well reproducible in the majority of patients, although considerable discrepancies in T2 estimates made by two independent observers were found in a few patients. The median doubling time was 34.9 days (estimated 95% range 3.9 to 352 days). The variation of T2:s between patients was significantly (P = 0.0001) larger than that between T2: of multiple metastases in the same patients. The growth of the metastases seemed to be well described by a simple exponential function in all patients with more than two measurements, without evidence of Gompertzian growth. There seemed to be a linear correlation between the logarithm of T2 and log-survival time from diagnosis of metastatic disease, even if only one third of the variation of survival times between patients could be explained by differences in T2. T2 was not a significant factor for survival in Cox-analysis (P = 0.10).

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Section: Resultscontrasting

confidence: 53%

mentioning

confidence: 99%

Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma

Blomqvist

Wıklund²,

Tarkkanen³

et al. 1993

Br J Cancer

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“…Em nosso estudo, o sexo do paciente não influenciou significativamente a sobrevida global e livre de doença. Estudos previamente publicados apresentam resultados semelhantes 16,[20][21][22] . O resultado a longo prazo das ressecções de metástases pulmonares varia dependendo da histologia tumoral.…”

Section: Discussionunclassified

Ressecção cirúrgica de metástases pulmonares: estudo prospectivo em 182 pacientes

Younes¹,

Haddad²,

Ferreira³

et al. 1998

Rev. Assoc. Med. Bras.

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RESUMO -OBJETIVO. O presente estudo visa ava UNITERMOS:Metástases. Pulmão. Prognóstico. Cirurgia. INTRODUÇÃOO diagnóstico de metástases pulmonares em pacientes portadores de tumores malignos é considerado um sinal de doença sistêmica e por muitos anos caracterizado como fase terminal da evolução do paciente. O tratamento convencional de pacientes com metástases pulmonares consiste em quimioterapia, hormonioterapia e, por vezes, radioterapia. Os resultados observados nos diferentes estudos apresentam resposta objetiva ao tratamento que não alcança 30% a 40% dos pacientes e com raros casos de resposta completa e conseqüen-te potencial de cura (sobrevida global de cinco anos geralmente inferior a 1%). Esses tratamentos são considerados por muitos especialistas como essencialmente paliativos.Para alguns tipos histológicos, como, por exemplo, sarcoma de partes moles, as metástases pulmonares podem representar o primeiro local de recidiva em 50% dos pacientes 1 . Em uma série, mais que 70% dos pacientes com metástases pulmonares isoladas foram curados e livres de doença após ressecção dessas lesões 2 .Apesar de múltiplos trabalhos na literatura mundial descreverem séries de pacientes submetidos à ressecção cirúrgica de metástases pulmonares, a literatura latino-americana é ainda muito pobre nesses estudos, com poucos relatos nesse sentido [3][4][5][6] . A maior série publicada na literatura latino-americana é de Esteva et al. 7 , que apresentaram um estudo retrospectivo de 61 pacientes operados durante um período de 14 anos. O núme-ro pequeno de casos e o período muito longo durante o qual foram admitidos esses pacientes tornam as conclusões deste e de outros estudos muito cautelosas. Por outro lado, a maioria absoluta dos estudos publicados na literatura mundial consiste em avaliações retrospectivas de prontuários acumulados durante muitos anos 8 . O presente estudo tem por objetivo: 1) avaliar de forma prospectiva, com protocolo rígido (evitando grandes flutuações de indicações, técnicas e tecnologia médica) realizado em curto período de tempo, os resultados do tratamento cirúrgico de metás-tases pulmonares; 2) identificar subgrupos de pacientes com riscos variados de recidiva e de morte decorrente da doença, baseado no impacto de fato-

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“…The slope of the line drawn between the points represented the rate of tumor growth. The horizontal distance between any two doubling points represented the TDT in days [20] (Fig. 1).…”

Section: Tumor Doubling Timementioning

confidence: 99%

“…using a well-described technique [19][20][21]. Briefly, successive chest radiographs were used to measure the changing diameters of each nodule.…”

Section: Tumor Doubling Timementioning

confidence: 99%

Tumor doubling time: A selection factor for pulmonary resection of metastatic melanoma

1998

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Variation in tumor doubling time in patients with pulmonary metastatic disease

Cited by 41 publications

References 9 publications

Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma

Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma

Ressecção cirúrgica de metástases pulmonares: estudo prospectivo em 182 pacientes

Tumor doubling time: A selection factor for pulmonary resection of metastatic melanoma

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