2011
DOI: 10.1530/eje-10-1021
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Variation in thyroid function in subclinical hypothyroidism: importance of clinical follow-up and therapy

Abstract: Subclinical hypothyroidism (SCH) is a common condition that is often observed without therapy. However, no evidence-based recommendation exists with regards to how patients with untreated SCH should be monitored. Monitoring involves regular assessment of symptoms and signs of hypothyroidism (HYPO) and biochemical tests of thyroid function. An important question when repeated tests of thyroid function are performed is how large a difference in test results is needed to be confident that the change is real and n… Show more

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Cited by 77 publications
(77 citation statements)
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“…SCH may progress to overt hypothyroidism, remain relatively stable for long periods or regress to a normal thyroid function depending on individual and population characteristics (40). In the Whickham study (7), women with elevated TSH levels (> 6 mU/L) and positive antithyroid antibodies had an annual rate of progression to overt hypothyroidism of 4.3%, while for women with high levels of TSH and negative thyroid antibodies, this rate was only 2.6%.…”
Section: What Are the Predictors Of Progression To Overt Hypothyroidism?mentioning
confidence: 99%
“…SCH may progress to overt hypothyroidism, remain relatively stable for long periods or regress to a normal thyroid function depending on individual and population characteristics (40). In the Whickham study (7), women with elevated TSH levels (> 6 mU/L) and positive antithyroid antibodies had an annual rate of progression to overt hypothyroidism of 4.3%, while for women with high levels of TSH and negative thyroid antibodies, this rate was only 2.6%.…”
Section: What Are the Predictors Of Progression To Overt Hypothyroidism?mentioning
confidence: 99%
“…In apparently healthy individuals, thyroid hormone concentrations show a narrow intraindividual variation (18), although certain circadian and seasonal (mainly due to seasonal differences in iodine intake) fluctuations have been observed (19). In diseased individuals, however, thyroid hormone concentrations seem subjected to a higher fluctuation as influenced among others by wasting syndromes, persistent inflammation, and cardiac comorbidities (19).…”
Section: Introductionmentioning
confidence: 99%
“…In diseased individuals, however, thyroid hormone concentrations seem subjected to a higher fluctuation as influenced among others by wasting syndromes, persistent inflammation, and cardiac comorbidities (19). Against this background, the objective of our study was to evaluate the association between both basal levels and longitudinal (3-month) variation of T3, thyroxine (T4), and thyroid stimulating hormone (TSH) and all-cause and cause-specific mortality.…”
Section: Introductionmentioning
confidence: 99%
“…A proportion of patients with SCH will progress to overt hypothyroidism, 5-8% per year depending on the degree of 71,72 This is to gauge the tempo of any tendency to progression and to detect consequent overt hypothyroidism.…”
Section: Follow-up Of Untreated Patientsmentioning
confidence: 99%