2018
DOI: 10.3389/fimmu.2018.02046
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Variation in the Untranslated Genome and Susceptibility to Infections

Abstract: The clinical outcomes of infections are highly variable among individuals and are determined by complex host-pathogen interactions. Genome-wide association studies (GWAS) are powerful tools to unravel common genetic variations that are associated with disease risk and clinical outcomes. However, GWAS has only rarely revealed information on the exact genetic elements and their effects underlying an association because the majority of the hits are within non-coding regions. Some of the variants or the linked pol… Show more

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Cited by 19 publications
(11 citation statements)
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“…′ UTR, and expression of long non-coding RNAs [lncRNA; (144)(145)(146)(147)]. Studies suggest that changes in gene expression can dysregulate immune pathways that are fundamental in disease outcomes (146,148).…”
Section: Discussionmentioning
confidence: 99%
“…′ UTR, and expression of long non-coding RNAs [lncRNA; (144)(145)(146)(147)]. Studies suggest that changes in gene expression can dysregulate immune pathways that are fundamental in disease outcomes (146,148).…”
Section: Discussionmentioning
confidence: 99%
“…Accumulating evidence highlights a role for common non-coding genetic variation in human health [38,39], in inflammatory responses [45,46], and even specifically in innate immune responses [47][48][49]. While the rest of our study focused on coding variants, i.e., variants that likely have a direct effect on protein function, we therefore additionally aimed to gain insight into the impact of non-coding common variants.…”
Section: Common Variants Are Exclusively Associated With the Immunological Response To C Albicansmentioning
confidence: 99%
“…Thus, it is not surprising, that several lncRNAs with disease-associated polymorphisms were implicated at the intersection of these three leading causes of death. Examples include NEAT1, Gas5, or ANRIL (see above), but also H19, LINC00305 and various other lncRNAs (Giral et al, 2018;Minotti et al, 2018;Ramsuran et al, 2018;Castellanos-Rubio and Ghosh, 2019). Besides these three major human health burdens, lncRNA SNPs have also been associated with rather rare disorders, such as HELLP (hemolysis, elevated liver enzymes, and low platelets).…”
Section: Snps In Other Disease-associated Lncrna Locimentioning
confidence: 99%