Variation in the association of <i>Der p 1</i> and <i>Der f 1</i> with asthma and rhinitis in 9‐11‐year‐old schoolchildren: The French six cities study

Sanyal, Shreosi; Baïz, Nour; Charpin, D.; Caillaud, D.; Blay, F. De; Lavaud, F.; Annesi‐Maesano, Isabella

doi:10.1111/cea.13139

Cited by 2 publications

(1 citation statement)

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“…Thus, it is necessary to actively identify risk factors that affect rehospitalization of children in order to provide timely intervention, thereby reducing the incidence of repeated hospitalization. Allergic diseases are known to be important contributors to the occurrence of pneumonia and aggravate the condition, 18 and the level of IgE is closely related to the occurrence of allergic diseases. 4 A study has found that repeated attacks of bronchial pneumonia in children are often accompanied by a significant increase in IgE levels, 11,12 and our findings further support this conclusion.…”

Section: Discussionmentioning

confidence: 99%

High immunoglobulin E level is associated with increased readmission in children with bronchopneumonia

You

Guo

Xiao

et al. 2019

Ther Adv Respir Dis

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Background: Increased immunoglobulin E (IgE) is associated with lower respiratory tract infections. The study aimed to evaluate the association between IgE and the rate of bronchopneumonia-related readmission within 12 months in children. Methods: A total of 1099 children aged over 1 year with bronchopneumonia, from 1 January 2015 to 31 December 2016, were enrolled. Unplanned readmissions within 12 months after discharge were observed. Multivariate regression analysis was used to identify independent risk factors for rehospitalization. Results: The rate of rehospitalization was 11.4% (125/1099). Compared to the nonreadmission children, IgE levels, the proportion of children with asthma and hospitalization duration were significantly higher in the readmission children ( p < 0.05). Compared to the children with normal IgE (≤ 165 IU/ml) levels, the risk of rehospitalization was significantly higher in children with abnormal IgE [odds ratio (OR) 1.781, 95% confidence interval (CI) 1.209–2.624, p = 0.004]. Children with IgE level more than three times the upper limit had even higher risks of readmission (OR 2.037, 95%CI 1.172–3.540, p = 0.012). Meanwhile, the risk of readmission in children with abnormal IgE combined with or without bronchial asthma was significantly higher (OR 2.548 and 1.918, 95% CI 1.490–4.358 and 1.218–3.020, p = 0.001 and 0.005, respectively). Conclusions: Children aged over 1 year with bronchopneumonia who had higher IgE levels are at increased risk for rehospitalization within the first 12 months of the index hospitalization and IgE level may be used as a predictor of rehospitalization in children with bronchopneumonia.

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