Variation in Resistin Gene Promoter Not Associated With Polycystic Ovary Syndrome

Urbanek, Margrit; Du, Yunpeng; Silander, Kaisa; Collins, Francis S.; Steppan, Claire M.; Strauss, Jerome F.; Dunaif, Andrea; Spielman, Richard S.; Legro, Richard S.

doi:10.2337/diabetes.52.1.214

Cited by 78 publications

(51 citation statements)

References 22 publications

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“…In their study, no association of serum resistin levels with body mass index was observed. Variation in resistin gene promoter was not associated with PCOS (Urbanek et al, 2003). These findings suggest that resistin is unlikely to be a major determining factor in PCOS.…”

Section: Introductionsupporting

confidence: 46%

“…The role of resistin in PCOS had been investigated in several studies, which proved that variation in resistin gene promoter was not associated with polycystic ovary syndrome (Urbanek et al, 2003). Serum resistin levels were not elevated in PCOS women with insulin resistance Seow et al, 2004), and resistin was therefore not regarded as a major determining factor of PCOS-associated insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Resistin levels of serum and follicular fluid in non-obese patients with polycystic ovary syndrome during IVF cycles

Lu¹,

Huang²,

Li³

et al. 2005

J. Zhejiang Univ. Sci.

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Abstract:Objectives: To measure serum and follicular resistin, steroids hormone levels in women with PCOS (polycystic ovary syndrome) (BMI (body mass index)<25 kg/m 2 ), to assess possible correlations of resistin to hormonal and metabolic parameters and to analyze the clinical outcomes of in vitro fertilization-embryo transfer (IVF-ET) in women with PCOS and tubal infertility. Study design: We analyzed the clinical outcomes of IVF-ET in women with PCOS (BMI<25 kg/m 2 ) and tubal infertility during the years 2002 to 2004 and compared the serum and follicular fluid resistin levels, estradiol (E 2 ), progesterone (P), testosterone (T) levels in 20 PCOS and 20 healthy, age-matched women without PCOS during IVF-stimulated cycles. The correlations between the resistin levels and the outcomes of IVF-ET were evaluated. Results: No significant differences in resistin levels of either serum or follicular fluid between PCOS and control group were found. However, resistin levels in serum were higher than that in follicular fluid in both groups. Multiple regression analysis showed that resistin levels in serum did not correlate with BMI, estradiol, LH (luteinizing hormone) and insulin level in fasting blood. No significant correlations were found between follicular fluid reisistin levels and fertilization rate, implantation rate, clinical pregnancy rate or early miscarriage rate in both PCOS and control groups. Conclusion: Our results show that resistin does not have correlation with the hormonal and metabolic parameters as well as the outcomes of IVF. These data suggest that resistin is unlikely to be a local determinant factor in steroidogenesis and growth and maturation of oocytes during IVF-ET in lean women with PCOS.

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Section: Introductionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 99%

Resistin levels of serum and follicular fluid in non-obese patients with polycystic ovary syndrome during IVF cycles

Lu¹,

Huang²,

Li³

et al. 2005

J. Zhejiang Univ. Sci.

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“…The SNPs had an allele frequency of >0.1 in Caucasians, and comprised four of the six common (>0.1) variations identified in previous studies that screened both coding and regulatory regions of the gene for polymorphisms [13,14,15,17,18,20,21]. In order to identify any additional SNPs in coding regions, we screened 760 bp of the promoter region and all four exons in 94 individuals of Finnish origin; however, we found no additional variants with an allele frequency of >0.1 [22]. The SNPs were genotyped by homogeneous MassEXTEND reaction using the MassARRAY System (Sequenom, San Diego, Calif., USA) as previously described [25].…”

Section: Methodsmentioning

confidence: 99%

Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects

et al. 2004

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Aims/hypothesis. Resistin is a peptide hormone produced by adipocytes that is present at high levels in sera of obese mice and may be involved in glucose homeostasis through regulation of insulin sensitivity. Several studies in humans have found associations between polymorphisms in the resistin gene and obesity, insulin sensitivity and blood pressure. An association between variation in the resistin gene and Type 2 diabetes has been reported in some, but not all studies. The aim of this study was to analyse variants of the resistin gene for association with Type 2 diabetes and related traits in a Finnish sample. Methods. In 781 cases with Type 2 diabetes, 187 spouse controls and 222 elderly controls of Finnish origin, we genotyped four previously identified non-coding single-nucleotide polymorphisms (SNPs): -420C>G from the promoter region, +156C>T and +298G>A from intron 2, and +1084G>A from the 3′ untranslated region. We then tested whether these SNPs were associated with Type 2 diabetes and related traits. Results. The SNPs were not significantly associated with Type 2 diabetes. However, SNPs −420C>G, +156C>T and +298G>A and the common haplotype for these three markers were associated with increased values of weight-related traits and diastolic blood pressure in cases, lower weight in elderly control subjects, and lower insulin sensitivity and greater acute insulin response in spouses. Furthermore, the +1084G allele was associated with lower HDL cholesterol in both cases and controls, higher systolic blood pressure and waist circumference in cases, and greater acute insulin response in spouse controls. Conclusions/interpretation. Our results add to growing evidence that resistin is associated with variation in weight, fat distribution and insulin resistance.

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“…This might also serve to increase our knowledge about certain forms of diabetes mellitus. For example, the chromosomal localization of the PTBP1 gene has been assigned to 19p13.3, which is a locus closely linked to Type 2 diabetes associated with the polycystic ovary syndrome (Urbanek et al, 2003). Furthermore, a model for increased insulin secretion in vivo displays signs of increased PTB binding to messengers for insulin and other secretory granule proteins (Kuwahata et al, 2007).…”

Section: Future Perspectivesmentioning

confidence: 99%

The importance of RNA binding proteins in preproinsulin mRNA stability

Fred

Welsh²

2009

Molecular and Cellular Endocrinology

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Variation in Resistin Gene Promoter Not Associated With Polycystic Ovary Syndrome

Cited by 78 publications

References 22 publications

Resistin levels of serum and follicular fluid in non-obese patients with polycystic ovary syndrome during IVF cycles

Resistin levels of serum and follicular fluid in non-obese patients with polycystic ovary syndrome during IVF cycles

Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects

The importance of RNA binding proteins in preproinsulin mRNA stability

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