Variation in phosphorus and sulfur content shapes the genetic architecture and phenotypic associations within the wheat grain ionome

Fatiukha, Andrii; Klymiuk, Valentyna; Peleg, Zvi; Saranga, Yehoshua; Çakmak, İsmail; Krugman, Tamar; Korol, Abraham B.; Fahima, Tzion

doi:10.1111/tpj.14554

Cited by 14 publications

(9 citation statements)

References 95 publications

(127 reference statements)

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“…The study revealed the advantage of the ionomics approach, when all important grain macro-and microelements, and trace metals are phenotyped to analyze their relationships and to evaluate germplasm in an integrative manner. This study proved the importance of protein content as a key trait affecting the concentration of almost all grain elements, reported previously in Fatyukha et al [26]. Macroelements Mg, P, and S were also significantly correlated with other elements.…”

Section: Discussionsupporting

confidence: 88%

“…Considering the diversity of the germplasm and the high variation for agronomic traits, the concentrations of all elements were adjusted based on the correlations. Similar adjustments were made by Fatyukha et al [26], using protein content and P concentration as variables. The adjustments made in this study were well justified and allowed more precise evaluation of genetic resources.…”

Section: Discussionmentioning

confidence: 98%

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Variation of Macro- and Microelements, and Trace Metals in Spring Wheat Genetic Resources in Siberia

Shepelev

Morgounov²,

Flis

et al. 2022

Plants

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Western Siberia is one of the major spring wheat regions of Russia, cultivating over 7 Mha. The objective of the study was to evaluate the variation of macro- and microelements, and of trace metals in four distinct groups of genetic resources: primary synthetics from CIMMYT (37 entries), primary synthetics from Japan (8), US hard red spring wheat cultivars (14), and material from the Kazakhstan–Siberian Network on Spring Wheat Improvement (KASIB) (74). The experiment was conducted at Omsk State Agrarian University, using a random complete block design with four replicates in 2017 and 2018. Concentrations of 15 elements were included in the analysis: macroelements, Ca, K, Mg, P, and S; microelements, Fe, Cu, Mn, and Zn; toxic trace elements, Cd, Co, Ni; and trace elements, Mo, Rb, and Sr. Protein content was found to be positively correlated with the concentrations of 11 of the elements in one or both years. Multiple regression was used to adjust the concentration of each element, based on significant correlations with agronomic traits and macroelements. All 15 elements were evaluated for their suitability for genetic enhancement, considering phenotypic variation, their share of the genetic component in this variation, as well as the dependence of the element concentration on other traits. Three trace elements (Sr, Mo, and Co) were identified as traits that were relatively easy to enhance through breeding. These were followed by Ca, Cd, Rb, and K. The important biofortification elements Mn and Zn were among the traits that were difficult to enhance genetically. The CIMMYT and Japanese synthetics had significantly higher concentrations of K and Sr, compared to the local check. The Japanese synthetics also had the highest concentrations of Ca, S, Cd, and Mo. The US cultivars had concentrations of Ca as high as the Japanese synthetics, and the highest concentrations of Mg and Fe. KASIB’s germplasm had near-average values for most elements. Superior germplasm, with high macro- and microelement concentrations and low trace-element concentrations, was found in all groups of material included.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 98%

Variation of Macro- and Microelements, and Trace Metals in Spring Wheat Genetic Resources in Siberia

Shepelev

Morgounov²,

Flis

et al. 2022

Plants

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“…Identifying the genetic determinants of between-cultivar variation would provide valuable tools for breeding crops with high Zn content. Sequencing and genome analysis of wild relative and pre-green revolution populations through quantitative trait loci (QTL) and genome-wide association studies have begun to address these needs and will contribute to enhancing the genetic variation available to breeders, as well as aiding genetic marker design (Velu et al, 2018;Ali and Borrill, 2020;Cu et al, 2020;Fatiukha et al, 2020;Gupta et al, 2021). QTL analysis of backcross recombinant inbred lines derived from O. sativa ''Nipponbare'' and the Australian wild rice O. meridionalis W1627 followed by fine mapping has identified specific genomic loci associated with increased Zn concentrations in grains (Ishikawa et al, 2017).…”

Section: Genetic Biofortification Approaches For Znmentioning

confidence: 99%

Zinc in plants: Integrating homeostasis and biofortification

et al. 2022

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Zinc plays many essential roles in life. As a strong Lewis acid that lacks redox activity under environmental and cellular conditions, the Zn 2+ cation is central in determining protein structure and catalytic function of nearly 10% of most eukaryotic proteomes. While specific functions of zinc have been elucidated at a molecular level in a number of plant proteins, wider issues abound with respect to the acquisition and distribution of zinc by plants. An important challenge is to understand how plants balance between Zn supply in soil and their own nutritional requirement for zinc, particularly where edaphic factors lead to a lack of bioavailable zinc or, conversely, an excess of zinc that bears a major risk of phytotoxicity. Plants are the ultimate source of zinc in the human diet, and human Zn deficiency accounts for over 400 000 deaths annually. Here, we review the current understanding of zinc homeostasis in plants from the molecular and physiological perspectives. We provide an overview of approaches pursued so far in Zn biofortification of crops. Finally, we outline a ''push-pull'' model of zinc nutrition in plants as a simplifying concept. In summary, this review discusses avenues that can potentially deliver wider benefits for both plant and human Zn nutrition.

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“…durum, cv. Langdon) and wild emmer wheat (accession G18-16) (Peleg et al, 2009;Fatiukha et al, 2020). The introgression and identification of wild emmer quantitative trait locus (QTL) linked to micronutrient accumulation in a hexaploid wheat background have been less reported.…”

Section: Introductionmentioning

confidence: 99%

“…It was available to study QTLs related to agronomically important traits in large sets of germplasm resources such as landraces (Liu et al, 2017), elite cultivars (Sukumaran et al, 2015), and advanced breeding lines (Wang et al, 2017) as well as backbone parents and their derived lines (Yu and Tian, 2012;Yu et al, 2014;Xiao et al, 2016;Liu et al, 2019). In wheat, GWAS has been extensively applied to reveal genomic regions controlling traits such as GPC (Liu et al, 2019), grain ionome (Fatiukha et al, 2020), and yield-related traits (Tadesse et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Association Study for Grain Micronutrient Concentrations in Wheat Advanced Lines Derived From Wild Emmer

Liu

Huang

et al. 2021

Front. Plant Sci.

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Wheat is one of the important staple crops as the resources of both food and micronutrient for most people of the world. However, the levels of micronutrients (especially Fe and Zn) in common wheat are inherently low. Biofortification is an effective way to increase the micronutrient concentration of wheat. Wild emmer wheat (Triticum turgidum ssp. dicoccoides, AABB, 2n = 4x = 28) is an important germplasm resource for wheat micronutrients improvement. In the present study, a genome-wide association study (GWAS) was performed to characterize grain iron, zinc, and manganese concentration (GFeC, GZnC, and GMnC) in 161 advanced lines derived from wild emmer. Using both the general linear model and mixed linear model, we identified 14 high-confidence significant marker-trait associations (MTAs) that were associated with GFeC, GZnC, and GMnC of which nine MTAs were novel. Six MTAs distributed on chromosomes 3B, 4A, 4B, 5A, and 7B were significantly associated with GFeC. Three MTAs on 1A and 2A were significantly associated with GZnC and five MTAs on 1B were significantly associated with GMnC. These MTAs show no negative effects on thousand kernel weight (TKW), implying the potential value for simultaneous improvement of micronutrient concentrations and TKW in breeding. Meanwhile, the GFeC, GZnC and GMnC are positively correlated, suggesting that these traits could be simultaneously improved. Genotypes containing high-confidence MTAs and 61 top genotypes with a higher concentration of grain micronutrients were recommended for wheat biofortification breeding. A total of 38 candidate genes related to micronutrient concentrations were identified. These candidates can be classified into four main groups: enzymes, transporter proteins, MYB transcription factor, and plant defense responses proteins. The MTAs and associated candidate genes provide essential information for wheat biofortification breeding through marker-assisted selection (MAS).

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Variation in phosphorus and sulfur content shapes the genetic architecture and phenotypic associations within the wheat grain ionome

Cited by 14 publications

References 95 publications

Variation of Macro- and Microelements, and Trace Metals in Spring Wheat Genetic Resources in Siberia

Variation of Macro- and Microelements, and Trace Metals in Spring Wheat Genetic Resources in Siberia

Zinc in plants: Integrating homeostasis and biofortification

Genome-Wide Association Study for Grain Micronutrient Concentrations in Wheat Advanced Lines Derived From Wild Emmer

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