Variation in Peroxide Production by Beta Hemolytic Streptococci

Hadley, Philip B.; Hadley, Faith P.; Leathen, William W.

doi:10.1093/infdis/68.3.264

Cited by 5 publications

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“…One of the features of this work which is of greatest interest, and one which differentiates the changes we report from those involved in dissociation as usually considered, is the time factor. Mention of a recent paper by Hadley, Hadley and Eathen (1941) on "Variation in peroxide production by beta hemolytic streptococci" both illustrates this point and calls attention to the rather widespread occurrence among bacterial groups and test mediums of the sort of thing we are discussing. A quotation from the paper will suffice.…”

Section: Discussionmentioning

confidence: 92%

The Concept of Stability and Some of Its Implications

Parr

Robbins

1942

J Bacteriol

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Section: Discussionmentioning

confidence: 92%

The Concept of Stability and Some of Its Implications

Parr

Robbins

1942

J Bacteriol

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“…(3) Incubation and counting:-While pneumococci (Avery and MIorgan, 1924;Annear and Dorman, 1952) start producing peroxide during the logarithmic growth phase (7-10 hr), the peroxide from streptococci (Avery and Morgan, 1924;Hadley et al, 1941) occasionally may not be detectable for three or four days. It also frequently takes four days for all lactobacillus colonies to grow.…”

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confidence: 99%

Peroxide and Peroxidogenic Bacteria in Human Saliva

et al. 1957

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“…The first three papers have already appeared. (McKinney and Mellon, 1941) and (Hadley, Hadley, and Leathen, 1941). The pattern of bacterial variability associated with the action of these drugs in vivo has had no clear recognition heretofore; but, by way of anticipation, a clue to its nature is afforded by a certain similarity with what have sometimes been referred to as "environmental modifications.…”

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confidence: 99%

The Polyphasic Potencies of the Bacterial Cell; Its General Biologic and Chemotherapeutic Significance

Mellon

1942

J Bacteriol

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The experimental data of this communication really represent the fourth paper in a series dealing with the effects of the sulfonamide drugs on certain pathogenic bacteria as inifluenced by variability. The first three papers have already appeared. Mellon, 1941) (Hadley and and (Hadley, Hadley, and Leathen, 1941). The pattern of bacterial variability associated with the action of these drugs in vivo has had no clear recognition heretofore; but, by way of anticipation, a clue to its nature is afforded by a certain similarity with what have sometimes been referred to as "environmental modifications."These latter have never-been considered as true bacterial variants, or even as playing any r6le in the variation process, for two rather specious reasons. The first of these concerns their lack of stability; and the second, the misconception that they were merely morphologic alterations and therefore of no importance.In the first paper of the series we demonstrated that the erroneously styled series of involution forms of the pneumococcus occurring in vivo under the impact of sulfanilamide action, were actually phasic entities. This fact was considered of transcendent importance too, because the gradient of disappearing virulence which the several phases represented, made them vulnerable to destruction by the immunologic forces of the host. The proof of our contention as to the essentially phasic nature of the pleomorphic cell-forms, was made possible by their isolation in culture where their biochemical and colonial differences became measurable.It is our belief that the pattern of variability shown in the pneumococcus, while in itself distinctive, is not in principle a specific effect of the action of the sulfonamide compounds. In fact, the variability phenomena of the organism we are now about to describe have not been evoked by the action of these drugs; and yet the principles involved do not seem to differ and even the phenomena themselves have much in common. On the other hand, the latter are so much more inclusive that a unique opportunity is provided for the integration and clarification of relationships that have long been in dispute. This is due in part to the fact that it is unusual to encounter a single organism possessing such a range of variability as this one did.Incidentally, the intimate bearing of such considerations on the mode of action of the drugs that have made a new epoch in the history of medicine, should make 1 on August 4, 2020 by guest

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Variation in Peroxide Production by Beta Hemolytic Streptococci

Cited by 5 publications

References 0 publications

The Concept of Stability and Some of Its Implications

The Concept of Stability and Some of Its Implications

Peroxide and Peroxidogenic Bacteria in Human Saliva

The Polyphasic Potencies of the Bacterial Cell; Its General Biologic and Chemotherapeutic Significance

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