Variation in Levels of Flavonols Myricetin, Quercetin and Kaempferol—In Kenyan Tea (&amp;lt;i&amp;gt;Camellia sinensis L.&amp;lt;/i&amp;gt;) with Processed Tea Types and Geographic Location

King'ori, Simon M; Ochanda, S. O.; Koech, Robert

doi:10.4236/ojapps.2021.116054

Cited by 6 publications

(3 citation statements)

References 45 publications

(38 reference statements)

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“…Catechin and epicatechin are flavanols that are often found in fruits, vegetables, and tea [ 36 ]. Quercetin and kaempferol are flavonols that are particularly present in black and green tea, as well as fruits such as pomegranate and banana [ 37 , 38 ]. Both flavanols and flavonols have an antioxidant capacity associated with flavonoids, which causes a high redox potential, and therefore, a high reducing capacity (antioxidant action).…”

Section: Resultsmentioning

confidence: 99%

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

et al. 2022

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Sterile bracts can represent 80% of Araucaria angustifolia pinecone and are a rich source of phenolic compounds. This study aimed to optimize the extraction of the phenolic compounds from Araucaria angustifolia bracts using response surface methodology; the bioactivity properties were also investigated. The effects of the ethanol concentration, solute/solvent ratio, and temperature in relation to the phenolic composition and antioxidant activity were evaluated. The quantification and identification of the individual phenolic compounds (using high-performance liquid chromatography) and their bioactivity were evaluated. The optimized extraction conditions, which detected gallic acid, catechin, epicatechin, quercetin, and kaempferol, were obtained using 60% ethanol at a ratio of 1:38 (w/v) and a temperature of 80 °C. The extract showed high levels of phenolic classes and antioxidant activity. The extract also showed an inhibitory activity for pathogenic (approximately 80%, 10,000 µg/mL) and lactic acid (27.9%, 15,000 µg/mL) bacteria strains. The α-glucosidase inhibitory activity was approximately ten times greater than acarbose, demonstrating its high antiglycemic potential. No antioxidant and anti-inflammatory cellular activity were determined; however, a high cytotoxicity for non-tumor cells and the antiproliferative activity against the tumor cells were observed. Overall, the phenolic extract showed promising action in relation to the fight against the diseases related to oxidative stress and, hopefully, the application of the safe concentrations of the extract, based on bioavailability assays, can be verified.

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Section: Resultsmentioning

confidence: 99%

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

et al. 2022

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“…Through PPI analysis, we know that the main targets are quercetin and kaempferol, the two most common avonol glycosides. Previous studies have shown that quercetin and kaempferol play a signi cant role in anti-in ammation, anti-tumor and reducing blood lipids [20][21]. Therefore, we chose these two monomers to verify the positive effect of Kudingcha on obesity.…”

Section: Discussionmentioning

confidence: 99%

Effects and mechanism of Kudingcha on obesity

Sui

Liu

Gong

et al. 2022

Preprint

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Obesity is the world's most high-profile public health problem. Kudingcha has been used in traditional medicine because of its antioxidant, anti-inflammatory and weight loss properties. Quercetin and kaempferol are the main components rich in Kudingcha that are effective against obesity. Therefore, we used the method of network pharmacology to study the effects of quercetin and kaempferol to HepG2 cells on obesity. We obtained 20 hub genes through PPI results and the Cytoscape plug-in cytoHubba. The top 10 genes were found eventrully by GO and KEGG enrichment analysis. The results showed that the insulin resistance, PI3K-Akt signaling pathways and adipocytokine signaling pathway might be the central pathways associated with the treatment of obesity by kudingcha. Next, we used Real-Time PCR to detect the expression levels of ISNR, SLc2a4 and APOE genes to study its mechanism. The results showed that compared with the blank group, the expression of ISNR and SLc2a4 increased and the expression of APOE decreased. Our experiments confirmed that Kudingcha contains compounds that can improve insulin resistance and obesity. This can provide a reference for further research and application of Kudingcha in the treatment of obesity.

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“…Through PPI analysis, we know that the main targets are quercetin and kaempferol, the two most common avonol glycosides. Previous studies have shown that quercetin and kaempferol play a signi cant role in anti-in ammation, anti-tumor and reducing blood lipids (Kingori et al 2021;Gaikwad 2018). Therefore, we chose these two monomers to verify the positive effect of Kudingcha on obesity.…”

Section: The Mechanism Of Quercetin and Kaempferol Treated With Obesitymentioning

confidence: 99%

Effects and mechanism of Kudingcha on obesity based on network pharmacology

Sui,

Liu,

Gong

et al. 2023

Preprint

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Context: Obesity is the world's most high-profile public health problem. Kudingcha has been used in traditional medicine because of its antioxidant, anti-inflammatory and weight loss properties. Quercetin and kaempferol are the main components rich in Kudingcha that are effective against obesity. Objective We used the method of network pharmacology to study the effects of quercetin and kaempferol to HepG2 cells on obesity. Materials & methods We obtained 20 hub genes through PPI results and the Cytoscape plug-in cytoHubba. The top 10 genes were found eventrully by GO and KEGG enrichment analysis. The results showed that the insulin resistance, PI3K-Akt signaling pathways and adipocytokine signaling pathway might be the central pathways associated with the treatment of obesity by kudingcha. Next, we used Real-Time PCR to detect the expression levels of ISNR, SLc2a4 and APOE genes to study its mechanism. Results The results showed that compared with the blank group, the expression of ISNR and SLc2a4 increased and the expression of APOE decreased. Discussion & Conclusion: Our experiments confirmed that Kudingcha contains compounds that can improve insulin resistance and obesity. This can provide a reference for further research and application of Kudingcha in the treatment of obesity.

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Variation in Levels of Flavonols Myricetin, Quercetin and Kaempferol—In Kenyan Tea (<i>Camellia sinensis L.</i>) with Processed Tea Types and Geographic Location

Cited by 6 publications

References 45 publications

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

Bioactive Activities of the Phenolic Extract from Sterile Bracts of Araucaria angustifolia

Effects and mechanism of Kudingcha on obesity

Effects and mechanism of Kudingcha on obesity based on network pharmacology

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