Variation in isomeric products of a phosphodiesterase from the chloroplasts of<i>Phaseolus vulgaris</i>in response to cations

Diffley, Penny E.; Geisbrecht, Alan; Newton, Russell P.; Oliver, Michael; Smith, Christopher J.; Vaughan, Judith; Cleef, Jan van; Geyschem, Jan van; Walton, Terence J.; Bayliss, Mark; Brenton, A.G.; Harris, F.M.; Games, David E.; Wilkins, Adam C. R.; Roef, Luc; Onckelen, Harry Van; Witters, Erwin

doi:10.1080/11263500112331350760

Cited by 4 publications

(1 citation statement)

References 43 publications

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“…Plant PDEs degrading cGMP are elusive, as earlier bioinformatic searches failed to identify homologs of animal PDEs. However, PDE activity has been detected in crude protein extracts from different plant species in the 1970s [ 176 ] and partially purified PDE from chloroplasts of Phaseolus vulgaris displayed enzymatic activity in the presence of cAMP and cGMP [ 177 ]. A novel cGMP-activated PDE encoded by an ancient gene not represented in animals, is encoded in Arabidopsis by PDE1 [ 178 ], and more plant PDEs remain to be discovered and characterized.…”

Section: Nanodomains Surrounding Moonlighting Kinasesmentioning

confidence: 99%

Moonlighting Proteins Shine New Light on Molecular Signaling Niches

Turek

Irving

2021

IJMS

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Plants as sessile organisms face daily environmental challenges and have developed highly nuanced signaling systems to enable suitable growth, development, defense, or stalling responses. Moonlighting proteins have multiple tasks and contribute to cellular signaling cascades where they produce additional variables adding to the complexity or fuzziness of biological systems. Here we examine roles of moonlighting kinases that also generate 3′,5′-cyclic guanosine monophosphate (cGMP) in plants. These proteins include receptor like kinases and lipid kinases. Their guanylate cyclase activity potentiates the development of localized cGMP-enriched nanodomains or niches surrounding the kinase and its interactome. These nanodomains contribute to allosteric regulation of kinase and other molecules in the immediate complex directly or indirectly modulating signal cascades. Effects include downregulation of kinase activity, modulation of other members of the protein complexes such as cyclic nucleotide gated channels and potential triggering of cGMP-dependent degradation cascades terminating signaling. The additional layers of information provided by the moonlighting kinases are discussed in terms of how they may be used to provide a layer of fuzziness to effectively modulate cellular signaling cascades.

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Section: Nanodomains Surrounding Moonlighting Kinasesmentioning

confidence: 99%

Moonlighting Proteins Shine New Light on Molecular Signaling Niches

Turek

Irving

2021

IJMS

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Cyclic Nucleotides and Nucleotide Cyclases in Plants Under Stress

Pietrowska‐Borek

Chadzinikolau

Borek

2013

Improvement of Crops in the Era of Climatic Changes

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Cyclic nucleotides

2004

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The natural occurrence of cyclic nucleotides in higher plants, formerly a topic of fierce debate, is now established, as is the presence of nucleotidyl cyclases and cyclic nucleotide phosphodiesterases capable of their synthesis and breakdown. Here we describe the significant properties of cyclic nucleotides, also outlining their second messenger functions and the history of plant cyclic nucleotide research over its first three decades. Findings of the last five years are detailed within the context of the functional role of cyclic nucleotides in higher plants, with particular emphasis upon nucleotidyl cyclases and cyclic nucleotide-responsive protein kinases, -binding proteins and -gated ion channels, with future objectives and strategies discussed.

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Variation in isomeric products of a phosphodiesterase from the chloroplasts ofPhaseolus vulgarisin response to cations

Cited by 4 publications

References 43 publications

Moonlighting Proteins Shine New Light on Molecular Signaling Niches

Moonlighting Proteins Shine New Light on Molecular Signaling Niches

Cyclic Nucleotides and Nucleotide Cyclases in Plants Under Stress

Cyclic nucleotides

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