Variation in Immune-Related microRNAs Profile in Human Milk Amongst Lactating Women

Perri, Mariarita; Lucente, Maria Stella; Cannataro, Roberto; Luca, Ida Francesca De; Gallelli, Luca; Moro, Guido; Sarro, Giovambattista De; Caroleo, Maria Cristina; Cione, Erika

doi:10.2174/2211536607666180206150503

Cited by 31 publications

(43 citation statements)

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“…It is then with little surprise that this microRNA is the most studied milk microRNA (Benmoussa et al., ; Golan‐Gerstl et al., ; Melnik, ; Melnik & Schmitz, , ; Simpson et al., ; van Herwijnen et al., ). Other less‐expressed microRNAs have nevertheless been investigated in breast milk, like the immunity‐related microRNAs hsa‐miR‐223 or hsa‐miR‐146a (Iannaccone et al., ; Liao et al., ; Perri et al., ; van Herwijnen et al., ).…”

Section: Micrornas In Milkmentioning

confidence: 99%

“…In milk, microRNA expression was related to mammary gland conditions, including infections (Iannaccone et al., ; Lai et al., , ; Sun et al., ), cancer (Decmann et al., ; Do Canto et al., ; Hesari et al., ), pregnancy and lactation status (Carney et al., ; Perri et al., ; Schanzenbach et al., ), and maternal diet (Chen et al., ). Therefore microRNAs in milk were studied for their potential as biomarkers (Gustafson, Tyryshkin, & Renwick, ; Melnik & Schmitz, ) such as quality controls of commercial milk (Oh et al., ).…”

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

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Milk MicroRNAs in Health and Disease

Benmoussa

Provost

2019

Comp Rev Food Sci Food Safe

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MicroRNAs are small noncoding RNAs responsible for regulating 40% to 60% of gene expression at the posttranscriptional level. The discovery of circulating microRNAs in several biological fluids opened the path for their study as biomarkers and long‐range cell‐to‐cell communication mediators. Their transfer between individuals in the case of blood transfusion, for example, and their high enrichment in milk have sparked the interest for microRNA transfer through diet, especially from mothers to infants during breastfeeding. The extension of such paradigm led to the study of milk microRNAs in the case of cow or goat milk consumption in adults. Here we provide a comprehensive critical review of the key findings surrounding milk microRNAs in human, cow, and goat milk among other species. We discuss the data on their biological properties, their use as disease biomarkers, their transfer between individuals or species, and their putative or verified functions in health and disease of infants and adult consumers. This work is based on all the literature available and integrates all the results, theories, debates, and validation studies available so far on milk microRNAs and related areas of investigations. We critically discuss the limitations and outline future aspects and avenues to explore in this rapidly growing field of research that could impact public health through infant milk formulations or new therapies. We hope that this comprehensive review of the literature will provide insight for all teams investigating milk RNAs’ biological activities and help ensure the quality of future reports.

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Section: Micrornas In Milkmentioning

confidence: 99%

Section: Milk Micrornas In Health and Diseasementioning

confidence: 99%

Milk MicroRNAs in Health and Disease

Benmoussa

Provost

2019

Comp Rev Food Sci Food Safe

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“…It has been recently documented that microRNAs (miRNAs) are present in HM and that specific miRNAs are involved in the innate and acquired immune response. Apparently, miRNA distribution and expression profile are not affected by pasteurization [ 60 ]. As for NEC, Ng et al explored the role of dysregulated miRNAs in the pathogenesis of NEC and spontaneous intestinal perforation in preterm infants.…”

Section: Exploring the “Milky Way”: Reducing Oxidative Stress By Imentioning

confidence: 99%

Oxidative Stress and Necrotizing Enterocolitis: Pathogenetic Mechanisms, Opportunities for Intervention, and Role of Human Milk

Aceti

Beghetti

Martini

et al. 2018

Oxidative Medicine and Cellular Longevity

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This review will examine the role of oxidative stress (OS) in the pathogenesis of necrotizing enterocolitis (NEC) and explore potential preventive and therapeutic antioxidant strategies. Preterm infants are particularly exposed to OS as a result of several perinatal stimuli and constitutive defective antioxidant defenses. For this reason, OS damage represents a contributing factor to several complications of prematurity, including necrotizing enterocolitis (NEC). Being NEC a multifactorial disease, OS may act as downstream component of the pathogenetic cascade. To counteract OS in preterm infants with NEC, several antioxidant strategies have been proposed and different antioxidant compounds have been experimented. It is well known that human milk (HM) is an important source of antioxidants. At the same time, the role of an exclusive HM diet is well recognized in the prevention of NEC. However, donor HM (DHM) processing may impair antioxidant properties. As DHM is becoming a common nutritional intervention for high risk PI, the antioxidant status of preterm and DHM and potential ways to preserve its antioxidant capacity may merit further investigation.

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“…Other miRNAs associated with pathological and immune responses include miR-29a-3p (target interferon-γ, suppresses immune response to intracellular pathogens), miR-141-3p (biomarker for colon cancer), miR-378-3p (molecular switch involved in breast cancer cell metabolism), and miR-146b-5p (NF-kB signaling in innate immune responses). Colostrum contain miR-181a and hsa-miR-223, whose targets tend to be T and granulocytes cell populations, and hence affect the developmental stage of adaptive immune response in infants (67). Necrotizing enterocolitis afflicts 1-5% of premature neonates and there is a marked oxidative stress associated in the intestinal epithelial compartment.…”

Section: Milk Nutrimiromics In Infant Immunitymentioning

confidence: 99%