Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance?

Favatier, Florence; Bornman, Liza; Hightower, Lawrence E.; Günther, Eberhard; Polla, Barbara S.

doi:10.1379/1466-1268(1997)002<0141:vihgea>2.3.co;2

Cited by 111 publications

(84 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The protective allele G of HSPA1B rs1061581 occurred more frequently on the HLA-DRB3 haplotypes (consisting of all DRB1*03, DRB1*11/12, DRB1*13/14 haplotypes) in the cell line panel but especially on HLA-DRB1*03 haplotypes with no exception as already known (Favatier et al 1997;Dorak et al 2006). Most HLA-DRB4 haplotypes (consisting of all DRB1*04, DRB1*07, DRB1*09 haplotypes) which showed a risk association in males in the same group of cases and controls (Dorak et al 1999a) carried the risk allele A as reported before (Dorak et al 2006).…”

Section: Cell Line Datamentioning

confidence: 91%

“…HSPA1B SNP rs1061581 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) using the restriction endonuclease PstI (Dorak et al 2006). This PCR-RFLP method is equivalent to the PstI RFLP by Southern blotting analysis in earlier reports (Dorak et al 1994;Favatier et al 1997).…”

Section: Gene Variants and Genotypingsmentioning

confidence: 99%

“…Given the presumed correlation between cancer susceptibility and aging (Finkel et al 2007), it is plausible that the HSP70 gene variants may also play a role in cancer susceptibility. Due to the strong haplotypic relationships between HSP70 gene polymorphisms and HLA haplotypes (Favatier et al 1997;Dorak et al 2006), HSP70 polymorphisms may even account for some of the HLA associations observed in cancers. An association between higher HSP70 serum levels and increased lung cancer risk has been reported but in males only (Suzuki et al 2006).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

Ucisik-Akkaya

Davis

Gorodezky

et al. 2010

Cell Stress and Chaperones

View full text Add to dashboard Cite

Three heat shock protein 70 (HSP70) genes, HSPA1L, HSPA1A, and HSPA1B, are located within the human leukocyte antigen (HLA) class III region. HSPs act as stress signals and regulate natural killer cell response to cancer. HSP70 gene polymorphisms show disease associations partly due to their linkage disequilibrium with HLA alleles. To systematically evaluate their associations with childhood acute lymphoblastic leukemia (ALL), we examined the three functional single nucleotide polymorphisms (SNPs) rs2227956 (T493M) in HSPA1L, rs1043618 in HSPA1A 5′UTR, and rs1061581 (Q351Q) in HSPA1B by TaqMan assays or polymerase chain reaction-restriction fragment length polymorphism in 114 ALL cases and 414 controls from Wales (UK), in 100 Mexican Mestizo ALL cases and 253 controls belonging to the same ethnic group, and in a panel of 82 HLA-typed reference cell line samples. Homozygosity for HSPA1B rs1061581 minor allele G was associated with protection (odds ratio (OR)=0.37, 95% confidence interval (CI)=0.16-0.78; P=0.007) with genedosage effect (additive model) reaching significance (P= 0.0001) in the Welsh case-control group. This association was replicated in the second case-control group from Mexico (OR (recessive model)=0.49, 95% CI=0.24-0.96; P=0.03), and the pooled analysis yielded a strong association (Mantel-Haenszel OR=0.43, 95% CI=0.27-0.69, P= 0.0004). The association was stronger in males in each group and in the pooled analysis. A three-SNP haplotype including the major allele A of rs1061581 showed a highly significant increase in Welsh cases compared with respective controls (6.7% vs 1.8%; P=0.0003) due to the difference between male cases and controls. The protective allele of rs1061581 occurred more frequently on the HLA-DRB3 haplotypes (especially DRB1*03) in the cell line panel, but the HSPA1B association was independent from the HLA-DRB4 association previously detected in the same case-control group from Wales (adjusted P=0.001). Given the cancer promoting roles played by HSPs intracellularly as well as roles in immune surveillance when expressed on the cell surface and the known correlations between expression levels and the HSP polymorphisms, these results are likely to indicate a primary association and warrant detailed assessment in childhood ALL development.

show abstract

Section: Cell Line Datamentioning

confidence: 91%

Section: Gene Variants and Genotypingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

Ucisik-Akkaya

Davis

Gorodezky

et al. 2010

Cell Stress and Chaperones

View full text Add to dashboard Cite

show abstract

“…Among Hsp, Hsp70 family (namely Hsp70.1 and Hsp70.2) has been most consistently associated with protection against conditions involving oxidative stress, such as ischemia, inflammation or aging (Favatier et al, 1997). Furthermore, Hsp70 protein and its antibody have been identified as being involved in the pathogenesis of hypertension, atherosclerosis, coronary heart disease, acute heat-induced illness and heat stroke (Gromadzka et al, 2001;Wu et al, 2001;Pockley et al, 2003;Jin et al, 2004).…”

Section: Hsp70 Genotype and Heat Stressmentioning

confidence: 99%

Metabolic and hormonal acclimation to heat stress in domesticated ruminants

Bernabucci

Lacetera

Baumgard

et al. 2010

Animal

711

492

View full text Add to dashboard Cite

Environmentally induced periods of heat stress decrease productivity with devastating economic consequences to global animal agriculture. Heat stress can be defined as a physiological condition when the core body temperature of a given species exceeds its range specified for normal activity, which results from a total heat load (internal production and environment) exceeding the capacity for heat dissipation and this prompts physiological and behavioral responses to reduce the strain. The ability of ruminants to regulate body temperature is species-and breed-dependent. Dairy breeds are typically more sensitive to heat stress than meat breeds, and higher-producing animals are more susceptible to heat stress because they generate more metabolic heat. During heat stress, ruminants, like other homeothermic animals, increase avenues of heat loss and reduce heat production in an attempt to maintain euthermia. The immediate responses to heat load are increased respiration rates, decreased feed intake and increased water intake. Acclimatization is a process by which animals adapt to environmental conditions and engage behavioral, hormonal and metabolic changes that are characteristics of either acclimatory homeostasis or homeorhetic mechanisms used by the animals to survive in a new 'physiological state'. For example, alterations in the hormonal profile are mainly characterized by a decline and increase in anabolic and catabolic hormones, respectively. The response to heat load and the heat-induced change in homeorhetic modifiers alters post-absorptive energy, lipid and protein metabolism, impairs liver function, causes oxidative stress, jeopardizes the immune response and decreases reproductive performance. These physiological modifications alter nutrient partitioning and may prevent heat-stressed lactating cows from recruiting glucose-sparing mechanisms (despite the reduced nutrient intake). This might explain, in large part, why decreased feed intake only accounts for a minor portion of the reduced milk yield from environmentally induced hyperthermic cows. How these metabolic changes are initiated and regulated is not known. It also remains unclear how these changes differ between short-term v. long-term heat acclimation to impact animal productivity and well-being. A better understanding of the adaptations enlisted by ruminants during heat stress is necessary to enhance the likelihood of developing strategies to simultaneously improve heat tolerance and increase productivity.Keywords: ruminants, heat stress, metabolism, acclimation, adaptation ImplicationsHeat stress is a significant financial burden to animal agriculture in most areas of the world. Acclimation to heat stress imposes behavioral, physiological and metabolic adjustments to reduce the strain and enhances the likelihood of surviving the stress, and it also frequently reduces ruminant performance and compromises health. Improving our knowledge of physiological and metabolic mechanisms of acclimation may contribute to the development and adoption of proce...

show abstract

“…The 70-kDa Hsp (Hsp70) family shows exceptional polymorphism among human molecular chaperones [17]. The three major Hsp70 genes are located on chromosome 6p21 in the central part of the MHC locus, in close proximity to the genes encoding tumor necrosis factor a, lymphotoxin, complement C4 and 21-b-hydroxylase.…”

Section: Chaperone Polymorphisms and Mutationsmentioning

confidence: 99%

Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks

Nardai

Végh

Prohászka

et al. 2006

Trends in Immunology

View full text Add to dashboard Cite

Variation in hsp gene expression and Hsp polymorphism: do they contribute to differential disease susceptibility and stress tolerance?

Cited by 111 publications

References 0 publications

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility

Metabolic and hormonal acclimation to heat stress in domesticated ruminants

Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks

Contact Info

Product

Resources

About