Variation in heart rate influences the assessment of transient ischemic dilation in myocardial perfusion scintigraphy

Abstract

Background: Transient arrhythmias can affect transient ischemic dilation (TID) ratios. This study was initiated to evaluate the frequency and effect of normal heart rate change on TID measures in routine clinical practice.

A study of 18F-FLT positron emission tomography/computed tomography imaging in cases of prefibrotic/early primary myelofibrosis and essential thrombocythemia

“…FLT has been used in over 300 patients worldwide and no side effects related to the radiotracer have been reported. In a study performed at the University of Washington, Turcotte and colleagues [ 6 ] assessed the toxicity of [ 18 F] FLT in 20 patients with proven or suspected diagnosis of non-small cell lung cancer. Blood samples were collected for each patient at multiple times before and after [ 18 F] FLT-PET.…”

The prevalence and predictive accuracy of quantitatively defined transient ischemic dilation of the left ventricle on otherwise normal SPECT myocardial perfusion imaging studies

“…Dependence of TIDr on both blood pressure 20 and heart rate 21 have been reported. More complex schemes using normal limits that account simultaneously for gender, exercise type, body size, heart rate, and blood pressure, as well as same-day vs 2-day protocols and dual vs single isotope studies could be fabricated, but the subgroups for which we have data would become too small for adequate statistical analysis and it appears unlikely that we could compensate sufficiently for confounding variables to render TIDr significantly more useful for the detection of otherwise unrecognizable CAD.…”

Transient ischemic dilatation ratio derived from myocardial perfusion scintigraphy: What are we looking at?

“…21 They found an overall difference in HR of 6 ± 9 bpm between the HR during stress acquisition minus that during rest acquisition. Although this DHR is somewhat lower than that in this study (adenosine 4.6 ± 11.7, exercise 16.1 ± 15.2), they also found a lower DHR for the pharmacological stressed population than for exercise stressed population.…”