Variation in Depth of the Anterior Chamber of the Eye and Variation in Intraocular Pressure

Bleeker, G. M.

doi:10.1159/000304349

Cited by 4 publications

(3 citation statements)

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“…11). This confirms the observations of Bleeker (1963) measurements showed that the level in the vitreous body remained below 10-8 g/ml. when the free fluorescein in the blood was in the region of 104 g/ml.…”

Section: Methodssupporting

confidence: 92%

The active transport of fluorescein by the retinal vessels and the retina

Cunha-Vaz¹,

Maurice²

1967

The Journal of Physiology

213

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SUMMARY1. The movement of fluorescein across the retinal surface of the rabbit's eye was estimated by measuring the concentration gradient of the dye in the vitreous body. These measurements were made in vivo by means of a slit-lamp fluorophotometer, or were taken from frozen sections ofenucleated eyes.2. In the normal eye, fluorescein does not pass from the blood to the vitreous body across any part of the retina. When injected into the vitreous body it passes rapidly out across the entire retinal surface, even against a very large concentration gradient.3. A variety of metabolic and competitive inhibitors, effective in blocking organic anion transport in the kidney and liver, tend to abolish this unidirectional movement of fluorescein across the retina.4. The region occupied by the retinal vessels is more sensitive to inhibition than other areas of the retina. Occlusion of the vessels by diathermy prevents the exchange of fluorescein in this region.5. It appears, then, that there is an active transport of organic anions out of the vitreous body, both by the retinal capillaries and by the retina itself. The latter system is probably located in the pigment epithelium and seems to be carried forward to the rear surface of the iris.6. Since the walls of the retinal vessels of the rabbit are freely in contact with the vitreous body, the active transport must take place across the capillary endothelial cells themselves. These vessels have structural and permeability characteristics found only in the central nervous system and it is to be presumed that the anion transport system is shared by the capillaries of the brain.

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Section: Methodssupporting

confidence: 92%

The active transport of fluorescein by the retinal vessels and the retina

Cunha-Vaz¹,

Maurice²

1967

The Journal of Physiology

213

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“…Physiological variation must exist but how large? Bleeker (1963) did not give the statistics of this problem, and with the small fluctuations involved a good estimate would be difficult to obtain.…”

Section: Discussionmentioning

confidence: 98%

“…The significant difference between the two error estimates (a & b) moreover indicated that certain day to day components of variation must be involved in the last one (b). Bleeker (1963) studied the diurnal variation of ACD and pointed out that ACD, which indicates the position of the "ocular diaphragm", is incessantly altering in normal eyes. His observations were based on serial photographic recordings, which often showed small but fairly synchronous fluctuations of ACD in both eyes of the examined persons.…”

Section: Discussionmentioning

confidence: 99%

OPTICAL PACHYMETRY OF THE ANTERIOR CHAMBER A methodological study of errors of measurement using Haag Streit 900 instruments

Alsbirk¹

1974

Acta Ophthalmologica

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In connection with a population study of the anterior chamber depth (ACD), measured optically with Haag Streit 900 instruments, a field study of the method was performed. The random error of measurement was estimated in two ways: a) on the basis of the triple readings of the measuring procedure: s.d. = 0.020 mm and b) by reexaminations after a few weeks in a random sample of 52 persons: 0.037 mm, i.e. a significantly larger value. Corresponding results for corneal thickness were obtained (0.007 and 0.013 mm).A highly significant side difference -with larger left eye values -was (0.019 mm), in 900 pairs of eyes. The correction values due to radius of corneal curvature were found to be negligible. Against a background of large interpersonal variations of ACD the methodological problems seem to be small. ACD is a precise anatomical measure with this method. L n ACD (mean difference: 0.020 mm) and in corneal thickness

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Gonioskopie

Leydhecker¹

1973

Glaukom

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Variation in Depth of the Anterior Chamber of the Eye and Variation in Intraocular Pressure

Cited by 4 publications

References 0 publications

The active transport of fluorescein by the retinal vessels and the retina

The active transport of fluorescein by the retinal vessels and the retina

OPTICAL PACHYMETRY OF THE ANTERIOR CHAMBER A methodological study of errors of measurement using Haag Streit 900 instruments

Gonioskopie

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