Variation in Contents of Main Active Components and Antioxidant Activity in Leaves of Different Pigeon Pea Cultivars during Growth

Wei, Zuo‐Fu; Jin, Shuang; Luo, Meng; Pan, You-Zhi; Li, Tingting; Qi, Xiao‐Lin; Efferth, Thomas; Fu, Yujie; Zu, Yuangang

doi:10.1021/jf402455m

Cited by 31 publications

(19 citation statements)

References 33 publications

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“…ese studies illustrate the promising potential of N. lappaceum peels. However, the chemical and biological diversity of these plants depends on factors such as location, variety, management, and climatic conditions [38,39].…”

Section: Introductionmentioning

confidence: 99%

Active Compound Identification in Extracts of N. lappaceum Peel and Evaluation of Antioxidant Capacity

Monrroy

Araúz

García

2020

Journal of Chemistry

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Nephelium lappaceum and its by-products have great potential in the agricultural, pharmaceutical, and food industries. Some studies have shown that N. lappaceum by-products exhibit antimicrobial, antioxidant, antidiabetic, and anticancer properties. However, studies focused on identifying these compounds are rare. The availability of polyphenolic compounds can vary according to environmental conditions, soil, plant variety, and agronomic management. Therefore, in this study, the active compounds in extracts of the N. lappaceum peel were identified, and their antioxidant properties were evaluated using various extraction solvents and both ultrasonic and boiling extraction techniques. The chemical characterization of the N. lappaceum peel exhibited carbohydrate and reducing sugar contents of 12 and 2%, respectively. Phytochemical analysis indicated the presence of flavonoids, tannins, terpenes, and steroids. The total phenolic and flavonoid contents and total antioxidant capacity were the highest in the hydroethanolic extract obtained by ultrasound, with values of 340 mg gallic acid equivalents g−1, 76 mg quercetin equivalents g−1, and 2.9 mmol of Trolox equivalents g−1, respectively. Contrarily, the total anthocyanin content was higher in the acid extract obtained by ultrasound, with a value of 0.7 mg cyanidin-3-O-glucoside equivalents g−1. A total of 18 compounds—including hydroxybenzene, phenolic acid, flavonoids, fatty acids (saturated, unsaturated, and ester), vitamin, arenecarbaldehyde, and phthalate—were identified for the first time in the N. lappaceum peel using gas chromatography-mass spectrometry. The identified compounds have been previously isolated from other plants and reportedly exhibit anticancer, anti-inflammatory, antimicrobial, and antioxidant activities. Thus, the N. lappaceum peel was shown to be a potential source of bioactive compounds of immense importance in the pharmacological and food industries.

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Section: Introductionmentioning

confidence: 99%

Active Compound Identification in Extracts of N. lappaceum Peel and Evaluation of Antioxidant Capacity

Monrroy

Araúz

García

2020

Journal of Chemistry

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“…Pigeon pea's seeds, roots, leaves, and its extract have traditionally been used to treat diabetes (Grover et al, ) and measles (Nwodo et al, ). They also possess properties that are antifungal (Brito et al, ) and antioxidant activities (Wang et al, ; Wei et al, ; Zhang et al, ). Cajaninstilbene acid (CSA; Figure a), a bioactive compound derived from pigeon pea leaves, is reported to have effective therapeutic properties, such as anti‐inflammatory (Huang et al, ), antibacterial (Geng et al, ), antioxidative (Y. Liu et al, ), antiapoptotic (Jiang et al, ), antihepatitis (X. Y.Ji et al, ), and anticancer properties (Kadioglu et al, ).…”

Section: Introductionmentioning

confidence: 99%

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL‐induced signaling pathways

Sun

Wang

et al. 2018

Journal Cellular Physiology

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Osteoporosis is a form of osteolytic disease caused by an imbalance in bone homeostasis, with reductions in osteoblast bone formation, and augmented osteoclast formation and resorption resulting in reduced bone mass. Cajaninstilbene acid (CSA) is a natural compound derived from pigeon pea leaves. CSA possesses beneficial properties as an anti‐inflammatory, antibacterial, antihepatitis, and anticancer agent; however, its potential to modulate bone homeostasis and osteoporosis has not been studied. We observed that CSA has the ability to suppress RANKL‐mediated osteoclastogenesis, osteoclast marker gene expression, and bone resorption in a dose‐dependent manner. Mechanistically, it was revealed that CSA attenuates RANKL‐activated NF‐κB and nuclear factor of activated T‐cell pathways and inhibited phosphorylation of key signaling mediators c‐Fos, V‐ATPase‐d2, and ERK. Moreover, in osteoclasts, CSA blocked RANKL‐induced ROS activity as well as calcium oscillations. We further evaluated the therapeutic effect of CSA in a preclinical mouse model and showed that in vivo treatment of ovariectomized C57BL/6 mice with CSA protects the mice from osteoporotic bone loss. Thus, this study demonstrates that osteolytic bone diseases can potentially be treated by CSA.

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“…The current results demonstrated moderate pigeon pea leaves could enhance the antioxidant property of growing rabbis through increasing CAT, GSH‐Px and T‐AOC activities. Previous studies have found pigeon pea leaves possessed a lot of bioactivities including antioxidant activities, antibacterial, antiplasmodial, antitumor, hypoglycaemic, insecticidal and cajaninstilbene acid represent a valuable natural antioxidant source in the pigeon pea leaves (Ashidi, Houghton, Hylands, & Efferth, ; Cooksey, Dahiya, Garratt, & Strange, ; Duker‐Eshun et al, ; Green, Stevenson, Simmonds, & Sharma, ; Grover et al, ; Inman & Hoppe, ; Kong et al, ; Wei et al, ; Wu et al, ; Wu et al, ).…”

Section: Resultsmentioning

confidence: 99%

Evaluation of pigeon pea leaves (Cajanus cajan) replacing alfalfa meal on growth performance, carcass trait, nutrient digestibility, antioxidant capacity and biochemical parameters of rabbits

Chen

Zhu

Chen

et al. 2019

Animal Physiology Nutrition

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A 30‐day experiment was performed to determine the effect of pigeon pea leaves (PPL) on growth performance, carcass trait, meat quality, nutrient digestibility, antioxidant capacity and biochemical parameters of growing rabbits. In a completely randomized design, PPL replaced alfalfa meal at the level of 0%, 10%, 20% and 30%, which were named PPL0 (control), PPL10, PPL20 and PML30 respectively. Two hundred New Zealand white rabbits at 6 weeks with similar weight (870.23 ± 15.98 g) were allocated to four dietary groups with five replicates containing 10 rabbits/per replicate (male). The results showed that: (a) PPL powder contained 24.26% crude protein, 4.34% crude fat, 17.86% crude fibre, 7.05% ash, 1.35% calcium, 0.28% phosphorus, 1.09% lysine and 0.20% methionine, and the chemical compositions are on DM basis; (b) the ratio of feed to gain of rabbits fed diet PPL10 was significantly better (p < 0.05) than those fed other three diets; (c) the content of longissimus dorsi (LD) moisture in the rabbits fed diets without PPL (control group) was 12% lower than that in the PPL30 diets (60.1 vs. 72.1; p < 0.05). In PPL10, PPL20 and PPL30 diets, the leg muscle (LM) b*(yellowness) value was 33%, 30% and 22.6% higher than the control group respectively. The rabbits fed diets PPL0 had lower (p < 0.05) LM crude protein and ash and higher (p < 0.05) crude fat of LD and LM as compared with those fed other diets; (d) crude protein and energy digestibility of PPL0 and PPL10 diets were significantly higher (p < 0.05) than PPL30 diets; and (e) serum glutathione peroxidase (GSH‐Px) activity of the rabbits fed PPL10 and PPL30 diets was significantly higher (p < 0.05) than that fed PPL20 diets. Liver total antioxidant capacity (T‐AOC) activity of the PPL30 groups was 1.3% higher (p < 0.05) than the PPL10 group. Additionally, the control group (PPL0) had the highest (p < 0.05) blood urea nitrogen (BUN), total cholesterol (TCHO) and low‐density lipoprotein cholesterol (LDLC) content compared with the groups supplemented with PPL. The PPL30 group had the highest (p < 0.05) triiodothyronine (T3) and tetraiodothyroxine (T4) value among the dietary groups.

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Variation in Contents of Main Active Components and Antioxidant Activity in Leaves of Different Pigeon Pea Cultivars during Growth

Cited by 31 publications

References 33 publications

Active Compound Identification in Extracts of N. lappaceum Peel and Evaluation of Antioxidant Capacity

Active Compound Identification in Extracts of N. lappaceum Peel and Evaluation of Antioxidant Capacity

Cajaninstilbene acid inhibits osteoporosis through suppressing osteoclast formation and RANKL‐induced signaling pathways

Evaluation of pigeon pea leaves (Cajanus cajan) replacing alfalfa meal on growth performance, carcass trait, nutrient digestibility, antioxidant capacity and biochemical parameters of rabbits

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