Variation in Anti-inflammatory, Anti-arthritic, and Antimicrobial Activities of Different Extracts of Common Egyptian Seaweeds with an Emphasis on Their Phytochemical and Heavy Metal Contents

Shobier, Aida H.; Ismail, Mona M.; Hassan, Sahar W.M.

doi:10.1007/s12011-022-03297-1

Cited by 18 publications

(14 citation statements)

References 71 publications

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“…As shown in Figure 3A, the starting ethanolic extract presented a low effect on lipoxygenase activity (approx. 5%) at the tested concentration in contrast with the positive control, in accordance with the study by Shobier et al [82] for ethanolic extracts from Ulva fasciata and Ulva linza specimens. On the other hand, the inhibitory activity of the enzymatically modified extracts was up to 4-fold higher than that observed for the initial ethanolic extract, probably attributed to the oxidation products formed after the enzymatic treatment.…”

Section: Effect On the Activity Of Lipoxygenase From Glycine Max (Soy...supporting

confidence: 92%

Fungal Laccase-Mediated Enhancement of the Bioactivity of Green Algae Extracts

Spyrou¹,

Chatzikonstantinou²,

Giannakopoulou³

et al. 2023

Catal Res

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Biomass derived from green marine macroalgae Ulva sp. is considered a rich source of bioactive compounds. In the present study, we demonstrate the increased bioactivity of a phenolic-rich extract derived from green marine macroalgae Ulva intestinalis after its treatment with fungal laccases from Trametes versicolor and Agaricus bisporus. The phenolic composition of the extract, before and after its enzymatic treatment, was determined through several analytical methods. Furthermore, the antioxidant, enzyme-inhibitory, antimicrobial and cytotoxic activity of enzymatically modified and non-modified extracts was comparatively investigated. Depending on the laccase used, the enzyme-modified extracts exhibited different phenolic content and enhanced bioactivities compared to the non-treated ones. The enzymatically modified extracts presented enhanced antimicrobial, anti-lipoxygenase and anti-collagenase activities, and mild cytotoxicity. These results indicate that the proposed biocatalytic process could be applied to produce green macroalgal natural extracts with enhanced bioactivities paving the way for their implementation in the food, pharmaceutical, and cosmeceutical industries.

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Section: Effect On the Activity Of Lipoxygenase From Glycine Max (Soy...supporting

confidence: 92%

Fungal Laccase-Mediated Enhancement of the Bioactivity of Green Algae Extracts

Spyrou¹,

Chatzikonstantinou²,

Giannakopoulou³

et al. 2023

Catal Res

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“…Prolonged or untreated inflammatory reactions are the cause of a number of pathological problems that lead to a variety of illnesses, including diabetes, atherosclerosis, rheumatoid arthritis, and several other fatal conditions . The autoimmune inflammatory illness known as rheumatoid arthritis (RA) mainly affects the joints and is characterized by severe joint destruction, considerable bone and cartilage deterioration, proliferative synovitis and synovial inflammation, and restricted functioning . One crucial step in the pathology of rheumatoid arthritis is the recruitment of leukocytes into the connective tissue and joint area .…”

Section: Introductionmentioning

confidence: 99%

“…The invasion of several inflammatory cells into the affected and inflamed area releases proinflammatory cytokines TNF-α, IL-1β, IL-6, and interleukin-17 . Many other inflammatory mediators, including proteases, cyclooxygenases, phospholipases, prostaglandins, reactive oxygen species (ROS), nitric oxide (NO), and leukotrienes are crucial in the destruction of bone and inflammation of the synovial membrane during the progression of rheumatoid arthritis …”

Section: Introductionmentioning

confidence: 99%

“…4 Many other inflammatory mediators, including proteases, cyclooxygenases, phospholipases, prostaglandins, reactive oxygen species (ROS), nitric oxide (NO), and leukotrienes are crucial in the destruction of bone and inflammation of the synovial membrane during the progression of rheumatoid arthritis. 2 Trans-chalcone (1−3-diphenyl-2-propen-1-one) is a phytochemical having a molecular weight of 208.26 g/moL and is physically present as a yellow powder. It is soluble in chloroform, ether, benzene, and ethanol (slightly).…”

Section: Introductionmentioning

confidence: 99%

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Trans-Chalcone (1–3-diphenyl-2-propen-1-one) as a Therapeutic Candidate in Joint Inflammation via Reduction of TNF-α, IL-1β, IL-6, and IL-17 in Rodents: An In Vivo Study by RT-PCR and ELISA analysis

Jabbar,

Irfan,

Alamgeer

et al. 2024

ACS Omega

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Autoimmune disorders include vast and distinct illnesses and are characterized by an immune system-mediated attack on the body’s own tissues. Because of their ability to impact any portion of the body, their clinical symptoms are incredibly varied. The variations in symptoms are normally linked with the release and activation of vasoactive, chemotactic substances and cytokines. Cytokines perform a multitude of vital biological tasks, such as immune response control, inflammation, proliferation, and tissue repair. The reversal of inflammatory cytokines and leukocyte infiltration into the inflamed tissue by natural compounds provides an effective remedy for autoimmune diseases. Here, the oral administration of trans-chalcone (TC) for 28 days was tested with gradually increasing doses (30, 60, and 120 mg/kg) in complete Freund’s adjuvant (CFA)-provoked joint tissue stiffness in rats. Paw edema, arthritic index, joint stiffness, thermal and flexion pain, C-reactive protein, and rheumatoid factor (RF) levels were determined to check the tested drug effectiveness in a chronic inflammatory model. Molecular docking studies revealed strong binding affinity with inflammatory cytokines and mediators such as TNF-α, IL-17, COX-2, and iNOS; further, they were quantified at the mRNA level by RT-PCR and ELISA analysis. Oral administration of TC significantly ameliorated paw edema, thymus and spleen indices, joint stiffness, thermal and flexion pain, C-reactive protein, RF, mobility, and stance of the treated animals. This therapeutic effectiveness was linked with a reduction in the mRNA expression of proinflammatory cytokines such as IL-1β, IL-6, and IL-17. The findings of the reported research confirmed the effectiveness of TC in ameliorating joint stiffness and flexion pain by prominently lowering the inflammatory cytokines.

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“…These distinctive phytochemicals have significant biological effects and a wide range of pharmacological potential, including antibacterial, anti-inflammatory, anti-arthritic and antiproliferative actions. Seaweeds are also employed in the generation of novel pharmaceuticals 3,4 .…”

mentioning

confidence: 99%

Untitled

2023

IJPSR

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The present investigation was carried out to analyze the bioactive metabolites of red seaweed Champia compressa collected from Mandapam, Ramanathapuram district, Tamil Nadu, India. The collected sample was evaluated for qualitative and quantitative phytochemical screening analysis using five different solvents methods. The preliminary qualitative analysis of Champia compressa solvent extracts revealed the presence of flavonoids, tannins, steroids, cardiac glycosides, terpenoids, coumarins, alkaloids, saponins, and phenols. Further quantitative phytochemical analysis was performed using standard procedures that revealed the presence of the highest phenol content (506.67 mg GAE/g) found in aqueous extract and the lowest in chloroform extract (8.33 mg GAE/g). Similarly, alkaloid content (34.09 mg AE/g) was highest in ethyl acetate extract and lowest (15 mg AE/g) in aqueous extract. The highest steroid content (85.88 mg BSE/g) was observed in hexane extract, whereas the lowest (3.69 mg BSE/g) in chloroform extract, however terpenoid (30.25 mg LE/g) was higher in methanolic extract, and the least (3.38 mg LE/g) found in aqueous extract respectively. The FTIR characterization represents the functional groups of fourteen major peaks and sixteen bioactive compounds observed from the GC-MS spectrum from the methanolic extract. Hence these results confirmed the presence of potentially bioactive compounds of Champia compressa possibly used to develop novel drugs for treating various diseases. INTRODUCTION:Seaweeds are now understood to be a rich source of bioactive chemicals, which are credited with being rich in bioactive substances like polysaccharides, polyunsaturated fatty acids, pigments, polyphenols, minerals, and plant hormones that promote development.

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Variation in Anti-inflammatory, Anti-arthritic, and Antimicrobial Activities of Different Extracts of Common Egyptian Seaweeds with an Emphasis on Their Phytochemical and Heavy Metal Contents

Cited by 18 publications

References 71 publications

Fungal Laccase-Mediated Enhancement of the Bioactivity of Green Algae Extracts

Fungal Laccase-Mediated Enhancement of the Bioactivity of Green Algae Extracts

Trans-Chalcone (1–3-diphenyl-2-propen-1-one) as a Therapeutic Candidate in Joint Inflammation via Reduction of TNF-α, IL-1β, IL-6, and IL-17 in Rodents: An In Vivo Study by RT-PCR and ELISA analysis

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