Variation in acceptance of common oral antibiotic suspensions

Dagan, Ron; Shvartzman, Pesach; Liss, Zvi

doi:10.1097/00006454-199408000-00002

Cited by 61 publications

(21 citation statements)

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“…15 In the 14 estimates involving 7204 participants in whom antibiotics were prescribed for respiratory tract infections, the rate of adherence was slightly higher at 72.6% (95% CI = 65.5 to 79.7). However, there were studies included in this review that included only children, [16][17][18][19] were conducted in resource-poor 17,20,21 or secondary care settings, 7 and/or included small numbers. Furthermore, a number of different methods of measuring and defining adherence were used.…”

Section: Strengths and Limitationsmentioning

confidence: 99%

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Francis

Gillespie²,

Nuttall³

et al. 2012

Br J Gen Pract

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BackgroundNon-adherence to acute antibiotic prescriptions is poorly described and may impact on clinical outcomes, healthcare costs, and interpretation of research. It also results in leftover antibiotics that could be used inappropriately. AimTo describe adherence to antibiotics prescribed for adults presenting with acute cough in primary care, factors associated with non-adherence, and associated recovery. Design and settingProspective observational cohort study in general practices in 14 European primary care networks. MethodGPs recorded patient characteristics and prescribing decisions for adults with acute cough or clinical presentation suggestive of lower respiratory tract infection. Patients recorded antibiotic consumption and daily symptoms over 28 days. Rates of adherence to prescribed antibiotics were assessed, and factors associated with non-adherence were identified using logistic regression. Recovery was compared using a Cox proportional hazards model. ResultsOf 2520 patients prescribed immediate or no antibiotics at the index consultation, 282 (11.2%) took an antibiotic during the follow-up period that was not prescribed for them at the index consultation. Of these, 38.1% had no reconsultations during this period. Prior duration of symptoms, antibiotic treatment duration, antibiotic choice, and primary care network were all associated with adherence. There was no difference in time to recovery between those who were prescribed antibiotics at the index consultation and were fully adherent, partially adherent, and non-adherent. ConclusionNon-adherence to antibiotics for acute cough or lower respiratory tract infection is common. Duration of treatment, choice of antibiotic, and setting were associated with adherence but adherence to treatment was not associated with differences in recovery.

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Section: Strengths and Limitationsmentioning

confidence: 99%

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Francis

Gillespie²,

Nuttall³

et al. 2012

Br J Gen Pract

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show abstract

“…It has been suggested that the unpleasant oral properties associated with many medicines may, at least in part, contribute to the poor compliance rates that have been documented across a number of medicines over the years (e.g., Baguley, Lim, Bevan, Pallet, & Faust, 2012;Cram, Breitkreutz, Desset-Brèthes, Nunn, & Tuleu, 2009 can be particularly problematic when it comes to paediatric medications (Dagan, Shvartzman, & Liss, 1994;Iwai, 1997). Indeed, what is also worth bearing in mind here is that younger children may find such tastes especially unpleasant given their increased sensitivity to bitterness (e.g., Prescott, 2012;Spence, 2012).…”

Section: Introductionmentioning

confidence: 99%

Assessing the expectations associated with pharmaceutical pill colour and shape

Wan

Woods²,

Salgado‐Montejo

et al. 2015

Food Quality and Preference

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“…Many double-blind trials of antibiotics have included taste evaluations [1,2,5,6,8,9,[12][13][14][15][16][17][18][20][21][22]. In contrast, few such studies have been conducted in regular medical settings, and even fewer have concerned generics [4,23].…”

mentioning

confidence: 99%

Study of the acceptability of antibiotic syrups, suspensions, and oral solutions prescribed to pediatric outpatients

et al. 2008

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This observational study was designed to evaluate the acceptability of oral antibiotics (including generics) commonly prescribed to children by community practitioners in France. Between February and July 2006, the parents of 953 children enrolled by 46 pediatricians completed a questionnaire, including a taste assessment based on representations of five facial expressions. The proportions of "satisfactory" taste judgments showed a significant difference between amoxicillin-clavulanate reference product and its generics (77.9% vs. 65%, p = 0.01). The amoxicillin-clavulanate generics were more likely than the reference product to be spat out at least once (28.7% vs. 19%, p = 0.05). The full treatment course was taken by 91.7% and 82.3% of children prescribed the amoxicillin-clavulanate reference product and its generics, respectively (p = 0.02). The proportions of "satisfactory" taste judgments showed no significant difference between amoxicillin reference product and generics (64.3% vs. 72.5%, p = 0.3). The amoxicillin generics were not different from the reference product to be spat out at least once (8.6% vs. 14.3%, p = 0.2). The full treatment course was taken by 90.7% and 94.6% of children prescribed the amoxicillin reference product and its generics, respectively (p = 0.3). This study suggests the role of the active substance in the taste, and calls for the evaluation of palatability of future drugs (generics and references) before granting of the marketing authorization, particularly for active substances of poor taste; this palatability plays a significant role in the compliance of the treatment, notably in children. Poor compliance increases the risk of therapeutic failures and the emergence of resistance.

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Variation in acceptance of common oral antibiotic suspensions

Cited by 61 publications

References 0 publications

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Antibiotics for acute cough: an international observational study of patient adherence in primary care

Assessing the expectations associated with pharmaceutical pill colour and shape

Study of the acceptability of antibiotic syrups, suspensions, and oral solutions prescribed to pediatric outpatients

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