Variants of ESR1, APOE, LPL and IL-6 loci in young healthy subjects: association with lipid status and obesity

Abstract

Findings: BMI was increased (>25) in 22% of young healthy subjects. Increased cholesterol values (>5.0 mmol/L) were found in 23% of subjects, LDL-C (>3.0 mmol/L) in 23%, triglycerides (>1.7 mmol/L) in 11% of subjects. We found statistically significant differences in subjects' weight (p = 0.015), BMI (p = 0.023), and waist-hip ratio (WHR) (p = 0.015) in regard to their diet type; subjects with Mediterranean diet had the lowest values compared to those on continental and mixed diet. Significant associations were found for: LPL genetic polymorphic variant and abdominal obesity (p = 0.013), APO epsilon4 allele and hypercholesterolemia (p = 0.003), and ESR1-TA long allele and hypercholesterolemia (p = 0.011).Background: Human obesity is a multifactorial syndrome influenced also by genetic factors. Among gene variants found to be involved in body weight regulation and development of obesity, particular attention has been paid to polymorphisms in genes associated with obesity-related metabolic disorders. We explored the association of genetic polymorphisms of: estrogen receptor alpha (ESR1-TA repeats); interleukin-6 (IL-6 G-174C); apolipoprotein E (APO epsilon2, epsilon3, epsilon4); lipoprotein lipase Pvu II (LPL P+/-), with clinical variables: gender, age, body mass index (BMI), diet type and biological variables: triglycerides, cholesterol, HDL-C, LDL-C, CRP, homocysteine, urate, and glucose in 105 healthy young subjects (20-35 yrs) of Croatian origin.

Association between obesity categories with cardiovascular disease and its related risk factors in the MASHAD cohort study population

“…Sertic and colleagues reported an association between anthropometric factors including weight, BMI, and waist‐hip ratio (WHR) with diet type. Additionally, these results showed that several genetic variants (ESR‐1, LPL, and APO E) could be considered as predictive genetic risk factors for obesity‐related metabolic disorders in healthy adults . We also found that adherence to western pattern was associated with higher BMI …”

ApoE rs429358 and rs7412 Polymorphism and Gender Differences of Serum Lipid Profile and Cognition in Aging Chinese Population

“…In this current study, there appears to be a significant increase in female lipid profile respectively across the entire ApoE genotypes with gender taken into consideration (Tables 5 , 6 ) in the studied population with the exception of TG carriers of ApoE rs429358 genotype (Table 5 ). It is reported that heredity may explain ~35–60% of variability in the plasma lipids (Weiss et al, 2006 ), which may suggest that, regardless of the genetic factors; other factors (perhaps including in vivo endocrine activities) may contribute to the gender variation of serum lipids traits in Chinese adults (Sertic et al, 2009 ). The inconsistency with our present study in comparison other reported studies might be attributed to the geographic and ethnic differences in different population studies as well as the physiological status of the participants.…”

Association of gene variants with lipid levels in response to fenofibrate is influenced by metabolic syndrome status

“…APOE also plays an important role in the development of obesity and insulin resistance, which are components of MetS. Studies have also reported associations between MetS components and polymorphisms of APOE [30–31]. Despite the primary role of APOE to dyslipidemia, obesity, and insulin resistance in the development of the MetS, the functional interaction of MetS with APOE protein in the lipid-lipoprotein transport system and PPARα pathway remain unclear.…”