Variants of dermatofibroma - a histopathological study

Alves, João; Matos, Diogo; Barreiros, Hugo Frederico; Bártolo, Elvira

doi:10.1590/abd1806-4841.20142629

Cited by 92 publications

(136 citation statements)

References 17 publications

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“…The prevalence of this variant in the general population is unknown, but some evidence suggest that it is as low as 2.1% in different dermatofibroma types (1). Lipidized dermatofibroma was described by Iwata as "ankle-type" dermatofibroma (fibrous histiocytoma) due to its characteristic location on the lower extremities (2).…”

Section: Introductionmentioning

confidence: 99%

Distinguishing a Rare Variant of Lipidized Dermatofibroma from Nonlipidized Dermatofibromas in a Patient with Hypothyroidism and Alopecia Areata

Abdulla

Peck

Feneran

et al. 2017

Serbian Journal of Dermatology and Venereology

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Introduction. Lipidized dermatofibromas represent rare and often underrecognized variants of dermatofibromas. Histologically, dermatofibromas are composed of fibroblast-like spindle cells, foam cells, giant cells, siderophages, lymphocytes, capillaries, collagen fibers, and hyaline dermal collagen fibers. Lipidized dermatofibromas are characterized by numerous foam cells, Touton giant cells, and hyalinized wiry collagen in the stroma. Case report. We present a case of a 31-year-old woman with a history of hypothyroidism and alopecia areata, presenting with an enlarging 8 mm, firm erythematous nodule on her upper-mid back. Biopsy examination showed a cellular proliferation of spindle cells with peripheral collagen trapping and cholesterol clefts with associated foam cells and sclerosis, staining weakly positive for Factor XIIIa and negative for CD34. The diagnosis of a benign lipidized dermatofibroma was rendered. Conclusion. Lipidized dermatofibromas are rare histologic variants of dermatofibromas, biologically indolent, and should be distinguished from other cutaneous foamy histiocytic lesions, particularly xanthomas, which may alter patient management.

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Section: Introductionmentioning

confidence: 99%

Distinguishing a Rare Variant of Lipidized Dermatofibroma from Nonlipidized Dermatofibromas in a Patient with Hypothyroidism and Alopecia Areata

Abdulla

Peck

Feneran

et al. 2017

Serbian Journal of Dermatology and Venereology

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“…[1] DFs typically appear as firm hard papules, plaques, or nodules with color varying from yellow to brown or purple. [2] Most DFs are 0.5 cm to 2 cm in diameter and are commonly found on the limbs and trunk of adults.…”

Section: Introductionmentioning

confidence: 99%

“…[4,5] Histologically, the lesion is composed of interlacing fascicles of spindled cells set within a loose collagenous stroma associated with epidermal changes. [1] The lesional cells include a variable combination of fibroblasts, macrophages, and blood vessels. [1] Several clinical and histopathological dermatofibroma variants have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…[1] The lesional cells include a variable combination of fibroblasts, macrophages, and blood vessels. [1] Several clinical and histopathological dermatofibroma variants have been reported in the literature. These variants include cellular, epitheloid, atypical, lipidized, clear cell, palisading, atrophic, keloidal, granular cell, myxoid, lichenoid, balloon cell, signet-ring, hemosiderotic, and aneurysmal.…”

Section: Introductionmentioning

confidence: 99%

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Hemosiderotic dermatofibroma: Unique clinical presentation and dermoscopic findings of a rare dermatofibroma variant

Surprenant

Novice

Dreifke

et al. 2016

CRCP

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Hemosiderotic dermatofibromas (HDFs) are a rare variant of the relatively common dermatofibroma (DF). HDFs can clinically mimic melanoma as well as other melanocytic lesions and are diagnosed with histopathological examination. Histopathologic diagnosis is not straightforward as there are many DF variants and the features of several variants can often be found in one lesion. These lesions may represent a stage in development from common DF to aneurysmal dermatofibroma (ADF). This possible progression is important to recognize, as ADFs tend to exhibit increased tendency for local recurrence and can also be confused with malignant lesions. We present a case of a 65-year-old presenting with a rare HDF having unique clinical and dermatoscopic findings. Our case underscores the importance of recognizing this rare entity and stresses the importance of remaining mindful of the possible progression to ADF, an entity with increased propensity for recurrence.

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“…Atrophic DF is identified by dermal atrophy with prominent sclerotic collagen, as well as low cellularity. It has been proposed that dense elastic fibers around the vessels interfere with blood circulation, causing dermal atrophy, and thus low cellularity [7].…”

mentioning

confidence: 99%

Nodular lesion with polymorphous vascular pattern

Sousa

Oliveira

2017

Dermatol Pract Concept

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A 66-year-old female presented to our clinic with a 12-month history of a new, growing, asymptomatic nodule on her right leg. The physical examination revealed a firm, slightly depressible, pink nodule with light brown peripheral pigmentation and superficial visible vessels, measuring 10 mm in maximum diameter (Figure 1).Dermoscopy disclosed a central white structureless area, surrounded by an erythematous halo with areas of light brown atypical network. Additionally, fine linear-irregular and medium caliber, well-focused comma-like vessels were seen ( Figure 2).Complete surgical excision of the lesion was performed.Histopathological examination revealed an intradermic nodular lesion with few small fusiform cells, abundant eosinophilic collagen bundles and capillary vessels ( Figure 3). Immunohistochemistry was negative to CD34 and S100 protein. DiagnosisAtrophic dermatofibroma. Clinical CourseAs it is considered a benign non-melanocytic lesion, a con- Dermatofibroma (DF) is one of the most common skin neoplasms seen by dermatologists. Out of the various histopathological subtypes of DF, the atrophic variant is considered rare. Clinical and dermoscopic diagnosis of DF is straightforward in most cases. However, deeply atypical clinical and dermoscopic presentations can simulate other benign and malignant tumors. We present a case of atrophic DF, describing its dermoscopic features and the correlation with histopathology.

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Variants of dermatofibroma - a histopathological study

Cited by 92 publications

References 17 publications

Distinguishing a Rare Variant of Lipidized Dermatofibroma from Nonlipidized Dermatofibromas in a Patient with Hypothyroidism and Alopecia Areata

Distinguishing a Rare Variant of Lipidized Dermatofibroma from Nonlipidized Dermatofibromas in a Patient with Hypothyroidism and Alopecia Areata

Hemosiderotic dermatofibroma: Unique clinical presentation and dermoscopic findings of a rare dermatofibroma variant

Nodular lesion with polymorphous vascular pattern

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