Variantes alélicas de CYP1A1 y GSTM1 como biomarcadores de susceptibilidad a cáncer gástrico: influencia de los hábitos tabáquico y alcohólico

Lee, Kuen; Cáceres, Dante; Varela, Nelson; D, Atila Csendes; R, Horacio Ríos; S, Luis Quiñones

doi:10.4067/s0034-98872006000900004

Cited by 9 publications

(7 citation statements)

References 38 publications

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“…After extracting the DNAg, it was amplified by polymerase chain reaction and subsequent digestion with restriction enzymes (Lee et al 2006;Yun et al 2014).…”

Section: Genotypic Analysismentioning

confidence: 99%

“…The digested products were separated by 2% agarose gel electrophoresis and then visualized under ultraviolet light. The presence of the wild genotype *1A/*1A (T/T) is observed by a single band of 340 bp, the genotype *1A/*2A (T/C) is identified by three bands 340, 200 and 140 bp and the genotype *2A/*2A (C/C) is identified by two bands of 200 and 140 bp (Lee et al 2006;Yun et al 2014).…”

Section: Detection Of the Polymorphism Of The Cy-p1a1 Genementioning

confidence: 99%

“…The international nomenclature was used for the CYP1A1 gene, the wild genotype being *1A/*1A, the heterozygous *1A/*2A and the homozygous recessive *2A/*2A (Santes-Palacios et al 2016). For the GSTM1 gene, the null genotype [GSTM1 (-)] corresponds to the homozygous deletion of the gene that generates absence of expression and enzymatic activity; the present genotype [GSTM1 (+)] corresponds to the wild variant that has the active gene (homozygous or heterozygous) (Lee et al 2006).…”

Section: Polymorphism Nomenclaturementioning

confidence: 99%

“…Cancer is a priority disease for national and global public health; being the second cause of death worldwide. The year 2020 registered 19.3 million new cases and 9.9 million deaths related to cancer, many of these cancers have an environmental component (Sung et al 2021); in Peru, mortality from cancer in 2018 was 33,098 deaths (17,039 women The CYP1A1, CYP2C19, CYP2D6 and CYP17 genes that encode their respective isoenzymes are associated with different types of cancer (Lee et al 2006), by participating in the phase I metabolism of procarcinogens [polycyclic aromatic hydrocarbons (benzopyrene), arylamines, N-nitrosamines and dioxins] forming reactive metabolites that produce DNA adducts (Lee et al 2006;Attia 2010;Jin et al 2011;Rahal et al 2013;Acevedo et al 2014;Wongpratate et al 2020); of them, the CYP1A1 gene (Santes-Palacios et al 2016), has greater susceptibility to various types of cancer (Wongpratate et al 2020), such as gastric, colorectal, buccal, esophageal, laryngeal, mammary, cervix, lung , thyroid, prostate and kidney (Jin et al 2011;Balaji et al 2012;Meng et al 2015;Li et al 2016;Ding et al 2017).…”

Section: Introductionmentioning

confidence: 99%

“…The GSTM1*0 variant is the product of a homozygous deletion, due to an unequal recombination between two highly conserved regions of 4.2 kb that are located at the 5' and 3' ends of the gene respectively, generating a null allele that expresses an enzyme without activity (Board and Menon 2013;Rosero et al 2016;Heredia et al 2017), which leads to genomic instability that predisposes to various types of cancer (Heredia et al 2017;Satinder et al 2017). Figure 1 outlines the action of the CYP1A1 enzyme (expressed by the CYP1A1 gene) on benzopyrene (Route A), which converts it into a bioactive metabolite (7,8-dihydroxy-9,10-oxy-benzopyrene) that binds to the guanine of DNA generating the benzopyrene guanine adduct that induces mutagenic and carcinogenic processes (Lee et al 2006;Acevedo et al 2014;Wongpratate et al 2020); at the same time, the mechanism of conjugation of 4,5-benzopyrene epoxide (Route B) and 7,8,9,10-tetrahydroxy-7,8,9,10-tetrahydro benzopyrene (Route C) is represented by action of reduced glutathione (GSH g-Glu-Cys-Gly) which is expressed by GSTM1; additionally, GSH conjugates different reactive oxygen species (ROS), protecting cells from cytotoxic effects and oxidative stress (Board and Menon 2013;Usategui-Martín et al 2014;García-Martínez et al 2017).…”

Section: Introductionmentioning

confidence: 99%

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Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Alvarado¹,

Muñoz²,

Bartra³

et al. 2021

PHAR

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The polymorphic variants of CYP1A1 and the deletion of GSTM1 are present in the Peruvian mestizo population. Wild type and mutated genotypes (WT/*2A and *2A/ *2A) were identified, whose allele frequencies are 0.31 (T allele) and 0.69 (C allele), respectively; 53% with wild type GSTM1 (+) and 47% with null GSTM1. The frequency in Iquiteño emigrants was 0.72 CYP1A1*2A and 25% GSTM1 (-); from Lima 0.67 CYP1A1*2A and 33% of GSTM1 (-). The Hardy-Weinberg equilibrium test for the studied population showed that both frequencies are out of balance, p > .05. The presence of the risk allele of the CYP1A1*2A polymorphism and the deletion in the GSTM1 gene are high, which could be indicative of a phase I and II metabolic imbalance in this group of Peruvian populations, with potential risks of activating agents procarcinogens thus affecting the incidence of tumor pathologies with an environmental component.

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“…After extracting the DNAg, it was amplified by polymerase chain reaction and subsequent digestion with restriction enzymes (Lee et al 2006;Yun et al 2014).…”

Section: Genotypic Analysismentioning

confidence: 99%

Section: Detection Of the Polymorphism Of The Cy-p1a1 Genementioning

confidence: 99%

Section: Polymorphism Nomenclaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Alvarado¹,

Muñoz²,

Bartra³

et al. 2021

PHAR

Self Cite

View full text Add to dashboard Cite

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Risk factors for gastric cancer in Latin America: a meta-analysis

Bonequi

Meneses-González

Correa

et al. 2012

Cancer Causes Control

121

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Background Latin America has among the highest gastric cancer incidence rates in the world, for reasons that are still unknown. In order to identify region-specific risk factors for gastric cancer, we conducted a meta-analysis summarizing published literature. Methods Searches of PubMed and regional databases for relevant studies published up to December 2011 yielded a total of 29 independent case-control studies. We calculated summary odds ratios (OR) for risk factors reported in at least five studies, including socioeconomic status (education), lifestyle habits (smoking and alcohol use), dietary factors (consumption of fruits, total vegetables, green vegetables, chili pepper, total meat, processed meat, red meat, fish and salt) and host genetic variants (IL1B-511T, IL1B-31C, IL1RN*2, TNFA-308A, TP53 codon 72 Arg and GSTM1 null). Study-specific ORs were extracted and summarized using random-effects models. Results Chili pepper was the only region-specific factor reported in at least five studies. Consistent with multifactorial pathogenesis, smoking, alcohol use, high consumption of red meat or processed meat, excessive salt intake and carriage of IL1RN*2 were each associated with a moderate increase in gastric cancer risk. Conversely, higher levels of education, fruit consumption, and total vegetable consumption were each associated with a moderately decreased risk. The other exposures were not significantly associated. No prospective study data were identified. Conclusion Risk factor associations for gastric cancer in Latin America are based on case-control comparisons that have uncertain reliability, particularly with regard to diet; the specific factors identified and their magnitudes of association are largely similar to those globally recognized. Future studies should emphasize prospective data collection and focus on region-specific exposures that may explain high gastric cancer risk.

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Association between the SNPs in trace element-related metabolic genes and the risk of gastric cancer: a case–control study in Xianyou of China

Zheng

Liu

et al. 2019

J Genet

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This study aims to analyse the potential relationship between single-nucleotide polymorphism (SNPs) in trace elementrelated metabolic genes GSTM3, GSTP1, GPX1 and NKG2D and the risk of gastric cancer. A case-control study was conducted in the hospital of Xianyou, Fujian, China. In this study, a total of 299 patients with histopathological diagnosis in gastric cancer and 295 healthy control subjects were involved. Association between the SNPs in trace element-related metabolic genes and gastric cancer risk was analysed using the unconditional logistic regression model. No relationship was found between the SNPs of GSTM3 and GPX1 genes and gastric cancer risk. However, the risk of gastric cancer is related to the SNPs of NKG2D gene (rs1049174). Patients who carry the rs1049174 GG genotype have a higher incidence of the gastric cancer and a multivariate odds ratio (OR) of 1.85 (95% confidence intervals (CI): 1.02-3.38). Through haplotype analysis, two haplotypes (i.e. A_rs1746123-T_rs10431294-G_rs1049174 and T_rs1746123-T_rs10431294-C_rs1049174), OR of 0.29 (95% CI: 0.15-0.56) and 0.33, (95% CI: 0.22-0.50), respectively, were found to have lower incidence of gastric cancer. Meanwhile, another two haplotypes (T_rs1746123-C_rs10431294-C_rs1049174 and T_rs1746123-T_rs10431294-G_rs1049174), OR of 1.81 (95% CI: 1.40-2.34) and 3.09 (95% CI: 2.30-4.16), respectively, were found to have a higher incidence of gastric cancer. Further, no influence of the haplotype on the risk of cardia gastric cancer was found. However, the haplotype T_rs1746123-T_rs10431294-C_rs1049174 had lower incidence of noncardia gastric cancer by 46%. Our data showed that polymorphisms of trace element-related metabolic genes are important in gastric cancer pathology.

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Variantes alélicas de CYP1A1 y GSTM1 como biomarcadores de susceptibilidad a cáncer gástrico: influencia de los hábitos tabáquico y alcohólico

Abstract: Subjects that carry the m2 allelic variant of CYP1A1 and are exposed to tobacco smoke or alcohol have a significantly higher risk of developing gastric cancer.

Cited by 9 publications

References 38 publications

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Frequency of CYP1A1*2A polymorphisms and deletion of the GSMT1 gene in a Peruvian mestizo population

Risk factors for gastric cancer in Latin America: a meta-analysis

Association between the SNPs in trace element-related metabolic genes and the risk of gastric cancer: a case–control study in Xianyou of China

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