Variant rs2200733 and rs10033464 on chromosome 4q25 are associated with increased risk of atrial fibrillation after catheter ablation: Evidence from a meta-analysis

He, Jiake; Zhu, Wenzhen; Yu, Yang; Hu, Jinzhu; Hong, Kui

doi:10.5603/cj.a2017.0143

Cited by 10 publications

(10 citation statements)

References 36 publications

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“…To date, several meta-analyses of gene polymorphisms and AF susceptibility have been published and have identi ed associations, including chromosome 4q25 variants, CYP11B2 -344T>C, and mink S38G [40][41][42][43]. A growing number of studies have identi ed polymorphisms in both ZFHX3 and PRRX1, although they have not been reported through meta-analysis studies that could clarify their associations with AF susceptibility.…”

Section: Discussionmentioning

confidence: 99%

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Wu¹,

Chu²,

Zhuang³

2021

Preprint

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Background Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In this study, a meta-analysis was conducted to confirm these associations. Methods The PubMed, Embase, and Wanfang databases were searched, covering all publications before July 20, 2020. Results Overall, seven articles including 3,674 cases and 8,990 healthy controls for ZFHX3 rs2106261 and 1045 cases and 1407 controls for PRRX1 rs3903239 were included. The odds ratio (OR) [95% confidence interval (CI)] was used to assess the associations. Publication bias was calculated using Egger’s and Begg’s tests. We found that the ZFHX3 rs2106261 polymorphism increased AF risk in Asians (for example, allelic contrast: OR [95% CI]: 1.39 [1.31–1.47], P < 0.001). Similarly, strong associations were detected through stratified analysis using source of control and genotype methods (for example, allelic contrast: OR [95% CI]: 1.51 [1.38–1.64], P < 0.001 for HB; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for PB; OR [95% CI]: 1.55 [1.33–1.80], P < 0.001 for TaqMan; OR [95% CI]: 1.31 [1.21–1.41], P < 0.001 for high-resolution melt). In contrast, an inverse relationship was observed between the PRRX1 rs3903239 polymorphism and AF risk (C-allele vs. T-allele: OR [95% CI]: 0.83 [0.77–0.99], P = 0.036; CT vs. TT: OR [95% CI]: 0.79 [0.67–0.94], P = 0.006). No obvious evidence of publication bias was observed. Conclusion In summary, our study suggests that the ZFHX3 rs2106261 and PRRX1 rs3903239 polymorphisms are associated with AF risk, and larger case-controls must be carried out to confirm the above conclusions.

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Section: Discussionmentioning

confidence: 99%

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Wu¹,

Chu²,

Zhuang³

2021

Preprint

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“…Our meta-analysis results were consistent with previous meta-analysis, which only focused on rs2200733and rs10033464 and AF recurrence. [19] Previous meta-analysis only enrolled 6 publications involved in rs2200733 and 3 publications involved in rs10033464. And it found both 2 variants were associated with AF recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…There were a few meta-analyses involved in the limited sample size and variants on AF recurrence, which did not use updated data. [17,19] Therefore, it is necessary to carry out an updated meta-analysis to draw a more accurate conclusion. We combined all available data and derived a more precise and comprehensive assessment to update this systematic review and meta-analysis in order to find out the reliable associations of the recurrence of AF.…”

Section: Introductionmentioning

confidence: 99%

Association between gene variants and the recurrence of atrial fibrillation

Jiang¹,

Wang²,

Qu³

et al. 2019

Medicine

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Background: Studies showed the controversial results about the effect of common genetic polymorphisms on the atrial fibrillation (AF) recurrence. We performed the systematic review and meta-analysis to qualify the association between common genetic polymorphisms and AF recurrence. Methods: Articles were systematically retrieved PubMed, Web of Science, EMBASE, Wanfang, and CNKI database and 9 studies including 3204 patients were enrolled in our meta-analysis. Results: Results showed that the associations were significant under rs2200733 3 genetic models (TT vs CC: odds ratio [OR] [confidence interval [CI]] = 1.336 [1.061–1.683], P = .014; CT vs CC: OR [CI] = 0.759 [0.614–0.937], P = .01; TT vs CT + CC: OR [CI] = 2.308 [1.440–3.700], P = .001). The association was significant under rs10033464 genetic model (TT vs GG: OR [CI] = 1.517 [1.165–1.976], P = .002). Conclusions: Rs13376333 on chromosome 1q21 (in KCNN3 ), rs7193343 and rs2106261 on chromosome 16q22 (in ZFHX3 ) were not associated with AF recurrence in our meta-analysis. In total, our meta-analysis found that rs2200733 and rs10033464 on chromosome 4q25 (near PITX2 ) were associated with the risk of AF recurrence.

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“…102 There is some conflicting data in another European population the rs10033464 SNP was associated with AF recurrence post ablation 103 and in meta-analysis. 100,104 This variability may be explained in part by variation in increased levels of circulating biomarkers of myocardial fibrosis in patients with paroxysmal AF. 105 Of note, there is emerging evidence that other SNPs at 4q25 may increase left atrial scar formation and increase nonpulmonary vein triggers for AF recurrence, which may help inform future risk stratification when selecting patients for catheter ablation.…”

Section: Clinical Management Considerationsmentioning

confidence: 99%

Genetically Based Atrial Fibrillation: Current Considerations for Diagnosis and Management

Pensa

Baman

Puckelwartz

et al. 2022

Preprint

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Atrial fibrillation (AF) is the most common atrial arrhythmia and is subcategorized into numerous clinical phenotypes. Given its heterogeneity, investigations into the genetic mechanisms underlying AF have been pursued in recent decades, with predominant analyses focusing on early onset or lone AF. Linkage analyses, genome wide association studies (GWAS), and single gene analyses have led to the identification of rare and common genetic variants associated with AF risk. Significant overlap with genetic variants implicated in dilated cardiomyopathy syndromes, including truncating variants of the sarcomere protein titin, have been identified through these analyses, in addition to other genes associated with cardiac structure and function. Despite this, widespread utilization of genetic testing in AF remains hindered by the unclear impact of genetic risk identification on clinical outcomes and the high prevalence of variants of unknown significance (VUS). However, genetic testing is a reasonable option for patients with early onset AF and in those with significant family history of arrhythmia. While many knowledge gaps remain, emerging data support genotyping to inform selection of AF therapeutics. In this review we highlight the current understanding of the complex genetic basis of AF and explore the overlap of AF with inherited cardiomyopathy syndromes. We propose a set of criteria for clinical genetic testing in AF patients and outline future steps for the integration of genetics into AF care.

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Variant rs2200733 and rs10033464 on chromosome 4q25 are associated with increased risk of atrial fibrillation after catheter ablation: Evidence from a meta-analysis

Abstract: After catheter ablation, rs2200733 (TT or TT+TC) and rs10033464 (TT+TG or TG) were associated with increased risk of AF recurrence.

Cited by 10 publications

References 36 publications

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Association between ZFHX3 and PRR X1 polymorphisms and atrial fibrillation susceptibility

Association between gene variants and the recurrence of atrial fibrillation

Genetically Based Atrial Fibrillation: Current Considerations for Diagnosis and Management

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