Abstract:3239
Red blood cell (RBC) transfusion is a key treatment for patients with sickle cell disease (SCD), but remains complicated by the high incidence of RBC immunization. Despite provision of phenotypic Rh D, C, and E antigen-matched donor RBCs, patients continue to develop Rh antibodies. In many cases, these antibodies are considered autoantibodies with specificities for D, C, and e antigens because the patient's own RBCs type serologically positive for the corresponding antigen. Recent evidence … Show more
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