Variant interleukin 1 receptor antagonist gene alleles in sudden infant death syndrome

Highet, Amanda R.; Gibson, Catherine; Goldwater, Paul N.

doi:10.1136/adc.2010.188268

Cited by 11 publications

(4 citation statements)

References 29 publications

(32 reference statements)

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“…Allele 1, 2, 3, 4 and 5 carries 4, 2, 5, 3 and 6 repeats, respectively. 20 , 35 Due to easier statistical analysis the allele polymorphisms were divided into short and long, the short allele being allele 2 and the long allele being those with 3 repeats or more (alleles 1, 3, 4, and 5). 26 …”

Section: Methodsmentioning

confidence: 99%

The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infection

Stubljar

Jeverica

Jukić³

et al. 2015

Radiology and Oncology

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BackgroundHelicobacter pylori infection is the main cause of gastric cancer. The disease progression is influenced by the host inflammatory responses, and cytokine single nucleotide polymorphisms (SNPs) may have a role in the course of the disease. The aim of our study was to investigate proinflammatory cytokine polymorphisms, previously associated with the development of gastric cancer, in a Slovenian population.Patients and methods.In total 318 patients and controls were selected for the study and divided into three groups: (i) patients with gastric cancer (n = 58), (ii) patients with chronic gastritis (n = 60) and (iii) healthy control group (n = 200). H. pylori infection in patient groups was determined by serology, histology and culture. Four proinflammatory gene polymorphisms were determined (IL-1β, IL-1ra, TNF-α, TLR-4) in all subjects.ResultsWe found a statistically significant difference between males and females for the groups (p = 0.025). Odds ratio (OR) for gastric cancer risk for females was 0.557 (95% confidence interval [CI]: 0.233–1.329) and for chronic gastritis 2.073 (95% CI: 1.005–4.277). IL-1B-511*T/T homozygous allele for cancer group had OR = 2.349 (95% CI: 0.583–9.462), heterozygous IL-1B-511*T had OR = 1.470 (95% CI: 0.583–3.709) and heterozygotes in TNF-A-308 genotype for chronic gastritis had OR = 1.402 (95% CI: 0.626–3.139). Other alleles had OR less than 1.ConclusionsWe could not prove association between gastric cancer and chronic gastritis due to H. pylori in any cytokine SNPs studied in Slovenian population. Other SNPs might be responsible besides infection with H. pylori for the progression from atrophy to neoplastic transformation.

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Section: Methodsmentioning

confidence: 99%

The influence of cytokine gene polymorphisms on the risk of developing gastric cancer in patients with Helicobacter pylori infection

Stubljar

Jeverica

Jukić³

et al. 2015

Radiology and Oncology

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“…Many other variants have been evaluated in replication studies, however, nearly all of these do not reach statistical significance upon post hoc analyses or are borderline significant (58, 62–64). In the case of both IL-1 (65) and IL-1 receptor antagonist (66) gene variants, significant replication in a single study has been reported in SIDS.…”

Section: Resultsmentioning

confidence: 99%

Systems-level perspective of sudden infant death syndrome

Salomonis

2014

Pediatr Res

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Sudden Infant Death Syndrome (SIDS) remains one of the primary causes of infant mortality in developed countries. While the causes of SIDS remain largely inconclusive, some of the most informative associations implicate molecular, genetic, anatomical, physiological and environmental (i.e., infant sleep) factors. Thus, a comprehensive and evolving systems-level model is required to understand SIDS susceptibility. Such models, by being powerful enough to uncover indirect associations, could be used to expand our list of candidate targets for in-depth analysis. We present an integrated WikiPathways model for SIDS susceptibility that includes associated cell systems, signaling pathways, genetics and animal phenotypes. Experimental and literature-based gene-regulatory data has been integrated into this model, to identify intersecting upstream control elements and associated interactions. To expand this pathway model, we performed a comprehensive analysis of existing proteomics data from brainstem samples of SIDS infants. From this analysis, we discovered changes in the expression of several proteins linked to known SIDS pathologies, including factors involved in glial cell production, hypoxia regulation, and synaptic vesicle release, in addition to interactions with annotated SIDS markers. Our results highlight new targets for further consideration that further enrich this pathway model, which, over time, can improve as a wiki-based, community curation project.

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“…This has led to several investigations, which identified IL-1 and its receptor as the key ligands involved in Staphylococcus aureus-induced septic shock in several SIDS victims [19]. The origins of these fatal infections were in the upper respiratory tract.…”

Section: Upper Respiratory Tract Infectionsmentioning

confidence: 98%