Variant estrogen receptor–c-Src molecular interdependence and c-Src structural requirements for endothelial NO synthase activation

Li, Lei; Hisamoto, Koji; Kim, Kyung Hee; Haynes, M. Page; Bauer, Philip M.; Sanjay, Archana; Collinge, Mark; Baron, Roland; Sessa, William C.; Bender, Jeffrey R.

doi:10.1073/pnas.0704315104

Cited by 72 publications

(64 citation statements)

References 39 publications

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“…2C). To confirm such is the case, however, we expressed inactivating FLAGtagged Myr (c-Src G2A ) (15,21), SH3 (c-Src W118K ) (7), and SH2 (c-SrcR 175L ) (7,27) point mutants in c-Src Ϫ/Ϫ splenocytes (see Fig. S3A in the supplemental material).…”

Section: Resultsmentioning

confidence: 99%

c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton

Izawa

Zou

Chappel

et al. 2012

Molecular and Cellular Biology

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Osteoclasts are unique bone resorptive cells, necessary for maintaining skeletal homeostasis. A relative excess of their activity however, often eventuates in the common disorder osteoporosis. Thus, understanding the means by which osteoclasts resorb bone carries both physiological and clinical significance.The magnitude of skeletal resorption reflects osteoclast number and the matrix-degrading capacity of the individual cell. Osteoclast abundance is governed by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor B ligand (RANKL) interacting with their respective receptors, c-fms and RANK, on monocyte/macrophage precursors. In fact, the two cytokines, in combination, are sufficient for osteoclast formation in vitro and in vivo.

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Section: Resultsmentioning

confidence: 99%

c-Src Links a RANK/αvβ3 Integrin Complex to the Osteoclast Cytoskeleton

Izawa

Zou

Chappel

et al. 2012

Molecular and Cellular Biology

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“…Through this mechanism, estrogen activates eNOS via phosphatidylinositol 3-kinase/Akt, leading to phosphorylation of eNOS on serine 1177, enhancing NO production. This mechanism leads to the well described rapid effect of estrogen to enhance endothelial-dependent vasodilator responses mediated by NO, an effect that has been demonstrated both in vitro and in vivo (Williams et al, 1992;Stirone et al, 2005a;Li et al, 2007).…”

Section: B Rapid Effectsmentioning

confidence: 99%

Vascular Actions of Estrogens: Functional Implications

2008

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“…These rapid responses include activation of different downstream signaling pathways, for example, the mitogen-activated protein kinases (MAPKs) and phosphatidylinositol-3-kinase (PI3K) pathways, eNOS activation, cyclic AMP production and intracellular calcium mobilization, which in turn can modulate nuclear transcriptional events in a variety of normal or transformed cell lines (reviewed in ref. [16][17][18][19][20][21][22][23][24][25][26]. How ER localizes to the cell membrane is not clear.…”

Section: Estrogen Receptors In the Testismentioning

confidence: 99%