Variant complex translocation t(8;15;21) in acute myeloblastic leukemia (M2) associated with bilateral chloroma

Sundareshan, T.S.; Augustus, Meena; Yasha, T C; Shailaja, S.; Lalitha, N.

doi:10.1016/0165-4608(92)90319-4

Cited by 15 publications

(6 citation statements)

References 9 publications

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“…Preferential sites of chloroma were the small intestine, mediastinum, epidural site, uterus and ovary, which often are difficult for the detection and diagnosis in addition to the skin and lymph nodes known commonly. Malignant myeloid blast cells may occasionally form a solid mass in tissues outside the haemopoietic system [7,8]. Granulocytic sarcoma is considered to be rare and its frequent occurrence is associated with specific genetic changes such as t(8;21) [9,10].…”

Section: Discussionmentioning

confidence: 99%

Granulocytic sarcoma (chloroma) in HIV patient: a report

Rizzo¹,

Magro²,

Castaldo

et al. 2004

Forensic Science International

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Section: Discussionmentioning

confidence: 99%

Granulocytic sarcoma (chloroma) in HIV patient: a report

Rizzo¹,

Magro²,

Castaldo

et al. 2004

Forensic Science International

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“…[1][2][3][4] Myeloid sarcomas are most common in certain subtypes of AML, in particular M5a (monoblastic), M5b (monocytic), M4 (myelomonocytic), and M2 (myeloblastic with maturation). 9 The French-American-British cooperative group defined this subtype of AML, which is also referred to as acute monocytic leukemia, as having a bone marrow biopsy specimen showing 80% or more of the nonerythroid cells demonstrating monocytic lineage (therefore, less than 20% are of granulocytic lineage). In addition, fewer than 80% of the monocytic lineage cells must be monoblasts (i.e., maturing promonocytes are clearly evident).…”

Section: Discussionmentioning

confidence: 99%

“…When 80% or more of the cells are monoblasts, the lesion is classified as acute monoblastic leukemia (M5a). 9 In most instances, orbital myeloid sarcoma occurs in young children. It is rare among the orbital tumours of childhood, accounting for only 1 of 250 cases in a previous report.…”

Section: Discussionmentioning

confidence: 99%

Bilateral proptosis as initial sign of acute myeloid leukemia: case report and review of literature

Sune

2014

Int J Contemp Pediatr

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Then complete blood count, CT head (Figure 2), MRI was done .and bone marrow biopsy 9 (Figure 3) was done. Based on the clinical findings and imaging study results, the differential diagnosis included leukaemia, lymphoma, metastatic neuroblastoma, and idiopathic orbital inflammation (inflammatory pseudotumor). The initial peripheral blood cell count revealed an elevated white ABSTRACT We report bilateral proptosis as the unusual initial presentation of Acute Myeloid Leukemia (AML) in a child. A six years child presented with a history of painless proptosis in the both eyes with fever within 15 days. Radiological investigations were showing infiltration of orbit with the metastatic tumour cell. AML was diagnosed with complete blood count and bone marrow biopsy. The presumptive diagnosis of leukemic infiltration of the orbit and EOM was made, and urgent radiotherapy, allopurinol with high doses of vitamin A, intrathecal methotrexate, and intravenous daunorubicin were instituted. Proptosis was started to decrease. We report this case as AML can rarely present in child as a bilateral proptosis due to leukemic infiltration. Radiation treatment should be considered as an urgent treatment modality for this rare condition.

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“…The incidence of granulocytic sarcoma is similar in acute and chronic granulocytic leukemia [17]; and fourfold higher in myelogenous leukemia FAB M2, characterized by typical chromosomic translocation T 8;21, than in the general leukemic population [34,35]. The development of granulocytic sarcoma in patients with leukemia implies a poor prognosis, often heralding a blastic crisis [23].…”

Section: Discussionmentioning

confidence: 99%

Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

Almadori

Ninno

Cadoni

et al. 1996

International Journal of Pediatric Otorhinolaryngology

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Granulocytic sarcoma (chloroma) is a rare solid, extramedullary tumour composed of immature granulocytes, occurring during granulocytic leukemia. Leukemic involvement of the temporal bone is not uncommon and may present in a variety of ways. Symptomatic facial nerve paralysis is one of these. The authors report a case of facial nerve paralysis as the presenting symptom of leukemic relapse in a 16-year-old white male, affected by acute myelogenous leukemia FAB M2, karyotype 46xy, T8;21.

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Variant complex translocation t(8;15;21) in acute myeloblastic leukemia (M2) associated with bilateral chloroma

Cited by 15 publications

References 9 publications

Granulocytic sarcoma (chloroma) in HIV patient: a report

Granulocytic sarcoma (chloroma) in HIV patient: a report

Bilateral proptosis as initial sign of acute myeloid leukemia: case report and review of literature

Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature

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