Variant Analysis of CARD14 in a Chinese Han Population with Psoriasis Vulgaris and Generalized Pustular Psoriasis

Qin, Peipei; Zhang, Qilin; Chen, Mingfei; Fu, Xi’an; Wang, Chuan Tang; Wang, Zhenzhen; Yu, Gongqi; Yu, Yang; Li, Xiuyan; Sun, Yonghu; Wu, Wei; Yang, Baoqi; Liu, Honghong; Zhang, Furen

doi:10.1038/jid.2014.269

Cited by 36 publications

(39 citation statements)

References 11 publications

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“…However, some investigations with small sample sizes have obtained contrasting results (González-Lara et al, 2013;Qin et al, 2014). Functional studies of this SNP have not provided further verification.…”

Section: Discussionmentioning

confidence: 95%

“…After selection and data extraction according to our inclusion criteria, five studies were included in our analysis, comprising 32,807 cases and 45,458 controls (Jordan et al, 2012;Tsoi et al, 2012;González-Lara et al, 2013;Qin et al, 2014;Tang et al, 2014; Table 1). Data from each subgroup were treated as independent.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…From the five studies, a total of 17 datasets were used in the final analysis. Five subgroups from three studies involved Asian subjects (Jordan et al, 2012;Qin et al, 2014;Tang et al, 2014), and 12 subgroups from three studies concerned those of European ancestry (Jordan et al, 2012;Tsoi et al, 2012;González-Lara et al, 2013). As most studies did not categorize samples based on clinical subtype (psoriasis vulgaris or psoriasis arthritis), our analysis did not take this factor into account.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Although studies performed in different ethnic groups have suggested that certain CARD14 rs11652075 alleles may confer susceptibility to psoriasis, not all investigations have supported this association (González-Lara et al, 2013;Qin et al, 2014), leading to inconsistent conclusions. Hence, we performed a meta-analysis of all eligible studies to derive a more precise estimation of the association between the rs11652075 SNP and risk of psoriasis.…”

Section: Introductionmentioning

confidence: 99%

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The common CARD14 gene missense polymorphism rs11652075 (c.C2458T/p.Arg820Trp) is associated with psoriasis: a meta-analysis

Shi¹,

Li²,

Wang³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Recent genetic evidence suggests a robust association of the CARD14 single nucleotide polymorphism rs11652075 (c.C2458T/p. Arg820Trp) and other rare mutations in this gene with psoriasis. To assess whether combined data support the relationship between CARD14 rs11652075 and susceptibility to this disease, we conducted a meta-analysis. PubMed (MEDLINE), EMBASE, Web of Science, and the Cochrane Library were searched for relevant papers published in English. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effect models. Heterogeneity between studies was assessed using the Cochran's Q and I 2 statistics. A total of 2 G. Shi et al. Genetics and Molecular Research 15 (3): gmr.15038357 five published studies, including 32,807 psoriasis patients and 45,458 controls, met our inclusion criteria and were included in the metaanalysis. The pooled OR of the association between the minor allele of this polymorphism and psoriasis was 0.877 (95%CI = 0.834-0.922; P < 0.001). In a stratified analysis, pooled ORs relating to European and Asian ancestry were 0.883 (95%CI = 0.822-0.948) and 0.872 (95%CI = 0.812-0.936), respectively. Those calculated for studies with case sample sizes above and below 1000 were 0.912 (95%CI = 0.870-0.956) and 0.824 (95%CI = 0.734-0.924), respectively. No publication bias was present, and the exclusion of any single dataset did not substantially alter the corresponding pooled ORs. Due to the limited data available regarding clinical classification of cases and genotypes, subgroup stratification by clinical type was not performed. Our results demonstrate a significant association between the CARD14 rs11652075 polymorphism and psoriasis.

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Section: Discussionmentioning

confidence: 95%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The common CARD14 gene missense polymorphism rs11652075 (c.C2458T/p.Arg820Trp) is associated with psoriasis: a meta-analysis

Shi¹,

Li²,

Wang³

et al. 2016

Genet. Mol. Res.

View full text Add to dashboard Cite

show abstract

“…Abundant evidence shows that single nucleotide polymorphisms (SNPs) of the caspase recruitment domain (CARD) family member 14 (CARD14) gene are implicated in this condition (Jordan et al, 2012a,b;Tsoi et al, 2012;Qin et al, 2014;Aizu et al, 2015). In a previous study, we also determined that the rs4722404 SNP of CARD11 can increase risk of early-onset psoriasis vulgaris (PsV; Shi et al, 2016).…”

Section: Introductionmentioning

confidence: 90%

Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population

Shi¹,

Zhang²,

Liao³

et al. 2017

Genet. Mol. Res.

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Genetic and pathological findings in a boy with psoriasis and C3 glomerulonephritis: A case report and literature review

Lei

Cao

et al. 2020

Molec Gen & Gen Med

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show abstract

Variant Analysis of CARD14 in a Chinese Han Population with Psoriasis Vulgaris and Generalized Pustular Psoriasis

Cited by 36 publications

References 11 publications

The common CARD14 gene missense polymorphism rs11652075 (c.C2458T/p.Arg820Trp) is associated with psoriasis: a meta-analysis

The common CARD14 gene missense polymorphism rs11652075 (c.C2458T/p.Arg820Trp) is associated with psoriasis: a meta-analysis

Lack of association between CARD10/CARMA3 tag SNPs and psoriasis vulgaris in the southern Chinese population

Genetic and pathological findings in a boy with psoriasis and C3 glomerulonephritis: A case report and literature review

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