Variance imputation for overviews of clinical trials with continuous response

Follmann, Dean; Elliott, Paul; Suh, Il; Cutler, Jeffrey A.

doi:10.1016/0895-4356(92)90054-q

Cited by 1,146 publications

(641 citation statements)

References 3 publications

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“…However, these data are often not available. In these cases, standard errors were estimated using methods described by Follmann et al (1992). Correlations between repeated outcomes were estimated from P-values when available and, when unavailable, the lowest estimate from other studies was used.…”

Section: Discussionmentioning

confidence: 99%

Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis

et al. 2008

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The aim of this study was to determine the efficacy of palliative oxygen for relief of dyspnoea in cancer patients. MEDLINE and EMBASE were searched for randomised controlled trials, comparing oxygen and medical air in cancer patients not qualifying for home oxygen therapy. Abstracts were reviewed and studies were selected using Cochrane methodology. The included studies provided oxygen at rest or during a 6-min walk. The primary outcome was dyspnoea. Standardised mean differences (SMDs) were used to combine scores. Five studies were identified; one was excluded from meta-analysis due to data presentation. Individual patient data were obtained from the authors of the three of the four remaining studies (one each from England, Australia, and the United States). A total of 134 patients were included in the meta-analysis. Oxygen failed to improve dyspnoea in mildly-or non-hypoxaemic cancer patients (SMD ¼ À0.09, 95% confidence interval À0.22 to 0.04; P ¼ 0.16). Results were stable to a sensitivity analysis, excluding studies requiring the use of imputed quantities. In this small meta-analysis, oxygen did not provide symptomatic benefit for cancer patients with refractory dyspnoea, who would not normally qualify for home oxygen therapy. Further study of the use of oxygen in this population is warranted given its widespread use.

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Section: Discussionmentioning

confidence: 99%

Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis

et al. 2008

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“…If a study reported significant findings with a non-exact P value (i.e., P Ͻ 0.05 or P Ͻ 0.01), assigned values of P ϭ 0.05 and P ϭ 0.01, respectively, were used (30,31). For nonsignificant findings reported with a non-exact P value, a paired correlation value of r ϭ 0.5 to calculate the SD of the change was used (32)(33)(34)(35). To evaluate the robustness of this imputation method, 3 sensitivity analyses were performed while using the highest or lowest reported correlation from included studies, and while excluding studies with imputed data.…”

Section: Moyer Et Almentioning

confidence: 99%

Valgus Bracing for Knee Osteoarthritis: A Meta‐Analysis of Randomized Trials

Moyer

Birmingham

Bryant

et al. 2015

Arthritis Care & Research

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Objective. To evaluate the effects of valgus knee bracing on pain and function, and compliance and complications, in patients with medial knee osteoarthritis (OA). Methods. A meta-analysis of randomized controlled trials that compared changes in patient-reported pain and/or function in patients with medial knee OA was performed. Seven databases were searched from their inception to January 2014. Two reviewers independently determined study eligibility, rated risk of bias, and extracted data. Pooled estimates and 95% confidence intervals (95% CIs) for standardized mean differences (SMDs) for the improvement in pain (and function) were calculated. Event rates (proportions) were calculated for studies that reported complications.

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“…We imputed standard deviations of changes where these were not available using the method recommended in the Cochrane handbook (Section 16.1.3.2) (Higgins and Green, 2009). A correlation coefficient of 0.5 was assumed between baseline and follow-up measurements (Follmann et al, 1992). We performed a fixed effects meta-analysis unless there was significant heterogeneity in which case we used a random effects model with appropriate cautious interpretation.…”

Section: Meta-analysesmentioning

confidence: 99%

A systematic review of the effects of physical activity on physical functioning, quality of life and depression in older people with dementia

Potter

Ellard

Rees

et al. 2011

Int J Geriat Psychiatry

171

131

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Background: Depression is common in older people with dementia. Physical activity is effective in reducing depression in adults but there is limited evidence about its effectiveness in people with dementia. Design and Methods: A systematic review and partial meta-analysis of physical activity interventions in people with dementia is reported. We searched eight databases for English language papers and reference lists of relevant papers. Included studies reported a physical activity intervention lasting at least 12 weeks in which participants were older and had a diagnosis of dementia. Studies compared the intervention with a non-active or a no-intervention control and reported at least one outcome related to physical function, quality of life or depression. At least two authors independently assessed each paper for inclusion and for study quality and extracted data. Results: We included 13 randomised controlled trials with 896 participants. Three of six trials that reported walking as an outcome found an improvement, as did four of the five trials reporting timed get up and go tests. Only one of the four trials that reported depression as an outcome found a positive effect. Both trials that reported quality of life found an improvement. Conclusions: There is some evidence that physical activity interventions improve physical function in older people with dementia. Evidence for an effect on depression and quality of life is limited.

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Variance imputation for overviews of clinical trials with continuous response

Cited by 1,146 publications

References 3 publications

Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis

Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis

Valgus Bracing for Knee Osteoarthritis: A Meta‐Analysis of Randomized Trials

A systematic review of the effects of physical activity on physical functioning, quality of life and depression in older people with dementia

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