Variación de la expresión proteica en función de la gravedad del síndrome de apnea-hipopnea del sueño

Gámez, Bernabé Jurado; Moreno, José Luis Gómez-Chaparro; Calero, María Muñoz; Ruiz-Laguna, Julia; Cabrera, Luís Muñoz; Povedano, Andrés Cosano; López-Barea, Juán

doi:10.1016/j.arbres.2009.12.007

Cited by 2 publications

(2 citation statements)

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“…Jurado Gámez et al, in 2010, applied sypro-ruby-stained 2D-PAGE for the analysis of serum protein signature of patients with different stages of OSA syndrome [57]. Patients were stratified by AHI into four groups – controls and mild, moderate, and severe OSA, each constituted by eight individuals.…”

Section: Proteomics In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

“…From this preliminary study, the authors moved on to apply a more powerful technique, iTRAQ isobaric tags associated with MALDI-TOF-TOF, aiming to obtain deeper knowledge and identify differently expressed proteins [58]. Researchers conducted a prospective observational study designed as described earlier [57]. To minimize any variance in findings, this study included only males referred to the Sleep Unit.…”

Section: Proteomics In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

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Overview of proteomics studies in obstructive sleep apnea

et al. 2015

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Obstructive sleep apnea (OSA) is an underdiagnosed common public health concern causing deleterious effects on metabolic and cardiovascular health. Although much has been learned regarding the pathophysiology and consequences of OSA in the past decades, the molecular mechanisms associated with such processes remain poorly defined. The advanced high-throughput proteomics-based technologies have become a fundamental approach for identifying novel disease mediators as potential diagnostic and therapeutic targets for many diseases, including OSA. Here, we briefly review OSA pathophysiology and the technological advances in proteomics and the first results of its application to address critical issues in the OSA field.

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Section: Proteomics In Obstructive Sleep Apnea Syndromementioning

confidence: 99%

Section: Proteomics In Obstructive Sleep Apnea Syndromementioning

confidence: 99%