Variables Which Might Predict the Response to Salvage Radiotherapy in Chinese Patients with Biochemical Failure after Radical Prostatectomy

Xu, Yong; Liu, Ranlu; Zhang, Z.; Qin, Hao; Qi, Shiyong; Li, J.; Zhang, Teng

doi:10.1159/000094810

Cited by 2 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The borderline value of PSA for excellent results of sRT is 1.5 and 2.0 ng/ml, respectively [29][30][31][32][33][34][35][36][37] . Other prognostic factors for the efficacy of sRT are: PSADT [38][39][40][41][42] , PSA before RP [22,23] , seminal vesicle invasion [23,24,27,43,44] and extracapsular extension [27,43,44] .…”

Section: Discussionmentioning

confidence: 99%

Radical Prostatectomy in High-Grade Prostate Cancer, Salvage and Adjuvant Radiotherapy

Broďák

Košina²,

Holub³

et al. 2010

Urol Int

View full text Add to dashboard Cite

Introduction: Prostate cancer with a Gleason score (GS) of 8–10 is linked to a higher risk of recurrence and progression. The aim of this paper is to evaluate treatment results of our high-risk patient cohort.Patients and Methods: The cohort of 42 patients with radical prostatectomy (RP) specimen histology GS 8–10 was assessed. The patients were followed up after RP and radiotherapy (RT) was delivered in case of a biochemical relapse. Adjuvant radiotherapy (aRT) was delivered only in case of a positive surgical margin (PSM). The following parameters were evaluated: biochemical progression-free survival (BPFS), overall survival (OS) and cancer-specific survival (CSS). The second objective was to evaluate adverse effects of RP and RT. Results: The median follow-up time was 88 months (18–168). RP led to BPFS in 16 patients (38%). Five patients with PSM underwent aRT and 20 underwent salvage radiotherapy (sRT). One patient died of myocardial infarction and 1 patient died of metastatic disease. Skeletal metastases were recorded in 2 patients. The BPFS in RP combinations with sRT or aRT was reached in 29 patients (69%). The OS and CSS in our cohort reached 95 and 98%, respectively. Conclusion: Management with aRT only in PSM was very effective, according to our retrospective study.

show abstract

Section: Discussionmentioning

confidence: 99%

Radical Prostatectomy in High-Grade Prostate Cancer, Salvage and Adjuvant Radiotherapy

Broďák

Košina²,

Holub³

et al. 2010

Urol Int

View full text Add to dashboard Cite

show abstract

The Limited Significance of a Longer Duration of Neoadjuvant Hormonal Therapy prior to Radical Prostatectomy for High-Risk Prostate Cancer in Japanese Men

Sakai¹,

Inoue²,

Hara³

et al. 2006

Urol Int

View full text Add to dashboard Cite

Introduction: The objective of this study was to evaluate the therapeutic significance of a longer duration of neoadjuvant hormonal therapy (NHT) followed by radical prostatectomy (RP) in Japanese men with high-risk prostate cancer. Materials and Methods: This study included a total of 42 patients with high-risk prostate cancer who were treated with NHT for ≧8 months prior to RP. In this series high-risk prostate cancer was defined as clinical stage T2c or T3, pretreatment serum prostate-specific antigen (PSA) >20 ng/ml and/or a biopsy Gleason score of 8–10. Biochemical recurrence was defined as a serum PSA level of ≧0.2 ng/ml. The data of these patients were retrospectively reviewed to clarify the relationships between treatment outcomes and various clinicopathological parameters. Results: The clinical stage was T2c in 13 patients and T3 in 29, the median value of pretreatment serum PSA was 43.3 ng/ml (range 9.7–322.2), and the biopsy Gleason score was 6 in 3 patients, 7 in 16 and ≧8 in 23. Following NHT (median 12 months, range 8–27), the median value of serum PSA decreased to 0.05 ng/ml (<0.01–18.3 ng/ml), and 15 patients (35.7%) were pathologically downstaged. During the median follow-up of 38 months (range 8–58), 11 patients (26.2%) developed biochemical recurrence, and the multivariate analysis identified pretreatment serum PSA, biopsy Gleason score and percentage of positive biopsy core as independent predictors of biochemical recurrence. The 3-year biochemical recurrence-free survival rate of the 42 patients was 68.3%, which was not significantly different from that of 34 patients who underwent RP for high-risk prostate cancer without NHT during the same period. Conclusion: A longer duration of NHT followed by RP for patients with high-risk prostate cancer resulted in a comparatively favorable outcome. However, despite the nonrandomized retrospective analysis, the present findings suggest no significant impact of long-term NHT on biochemical recurrence. Longer follow-up is needed to determine whether this therapeutic strategy is beneficial for high-risk prostate cancer patients.

show abstract

Variables Which Might Predict the Response to Salvage Radiotherapy in Chinese Patients with Biochemical Failure after Radical Prostatectomy

Cited by 2 publications

References 35 publications

Radical Prostatectomy in High-Grade Prostate Cancer, Salvage and Adjuvant Radiotherapy

Radical Prostatectomy in High-Grade Prostate Cancer, Salvage and Adjuvant Radiotherapy

The Limited Significance of a Longer Duration of Neoadjuvant Hormonal Therapy prior to Radical Prostatectomy for High-Risk Prostate Cancer in Japanese Men

Contact Info

Product

Resources

About