Variables associated with self-reported anxiety and depression symptoms in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy

Shi, Dayu; Li, Zongru; Li, Yongjie; Jiang, Qian

doi:10.1080/10428194.2020.1842397

Cited by 12 publications

(22 citation statements)

References 43 publications

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“…As a malignant tumor in the blood system, patients with leukemia will have a long drug treatment course, a high recurrence rate, and long-term chemotherapy. This situation makes patients prone to varying degrees of anxiety, depression, other emotions, and worry about the prognosis[ 11 , 12 ]. Therefore, choosing appropriate nursing measures is significant to cure disease with the help of the patient’s psychological state, quality of life, and the effect of chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Empathetic nursing with mindful cognitive therapy for fatigue, depression, and negative emotions in leukemia patients undergoing long-term chemotherapy

Lǚ¹,

Lü²,

Shao³

et al. 2022

WJCC

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BACKGROUND Leukemia is a broad term for blood cell cancer. Leukemia is divided into acute or chronic, depending on cell differentiation. Leukemia patients are prone to adverse reactions during chemotherapy, such as anxiety, depression, and even suicide, affecting prognosis. As a nursing model developed by three well-known cognitive psychologists, empathetic nursing with mindfulness cognitive therapy (ENMCT) can effectively reduce anxiety and depression and improve the quality of life in patients with chronic disease. AIM To explore the effect of ENMCT on cancer-induced fatigue, hope level, and negative emotions in patients with long-term leukemia chemotherapy. METHODS A total of 103 patients with long-term leukemia chemotherapy diagnosed and treated in our hospital from July 2017 to October 2019 were enrolled and randomly assigned to observation and control groups using the random number table approach. Fifty-one patients in the control group received routine nursing, while 52 patients in the observation group received empathic nursing with mindfulness cognitive therapy. After three months of nursing care, cancer-induced fatigue was measured with the Piper Fatigue Scale (PFS), hope level with the Herth Hope Index (HHI), and negative emotion with the Hamilton Anxiety Scale (HAMA)/Hamilton Depression Scale (HAMD). Self-management (Chinese Strategies Used by People to Promote Health) was also recorded. RESULTS The observation group’s total scores in behavior, cognition, emotion, feeling, and PFS were lower than the control group after the intervention ( P < 0.05). Keeping close contact with others, the attitude of taking positive actions, the attitude toward reality and future, and the total HHI score were higher in the observation group than the control group ( P < 0.05). The observation group’s HAMA and HAMD scores were lower than the control group ( P < 0.05). The observation group’s positive attitude, self-decision, and self-relief scores were greater than the control group ( P < 0.05). CONCLUSION Empathetic nursing with cognitive mindfulness therapy is beneficial in improving cancer-related fatigue, negative emotions, expectation level, and self-management ability in patients with long-term leukemia chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Empathetic nursing with mindful cognitive therapy for fatigue, depression, and negative emotions in leukemia patients undergoing long-term chemotherapy

Lǚ¹,

Lü²,

Shao³

et al. 2022

WJCC

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“…Rozpowszechnienie zaburzeń lękowych w populacji ogólnej jest szacunkowo oceniane na około 3-15% [20], natomiast wśród chorych onkologicznie oraz chorych na przewlekłą białaczkę szpikową wynosi około 10% [12,[21][22][23]. W badaniu własnym oceniano wpływ występowania poszczególnych skutków leczenia inhibitorami kinaz tyrozynowych na pojawienie się objawów lękowych u pacjentów chorych na PBSz.…”

Section: Dyskusjaunclassified

Side effects of treatment with tyrosine kinase inhibitors in patients with chronic myeloid leukemia and the occurrence of anxiety symptoms

Gibek¹,

Sacha²,

Cyranka³

2024

Psychiatr Pol

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Cel pracyCelem pracy było sprawdzenie czy poszczególne skutki uboczne leczenia inhibitorami kinaz tyrozynowych u pacjentów chorych na przewlekłą białaczkę szpikową mogą sprzyjać występowaniu objawów lękowych. Dodatkowo postanowiono sprawdzić, czy występują zależności pomiędzy wiekiem, płcią oraz czasem trwania leczenia a nasileniem lęku w podziale na występowanie poszczególnych skutków ubocznych.MetodaBadanie zostało przeprowadzone w Poradni Hematologicznej Szpitala Uniwersyteckiego w Krakowie, objęto nim 91 chorych. Do analizy występowania objawów lękowych zastosowano ankietę własną, Kwestionariusz Davida Goldberga GHQ-28 oraz czterowymiarowy Kwestionariusz 4DSQ.WynikiNajczęściej wymienianymi skutkami ubocznymi leczenia były: bóle kości i stawów oraz skurcze i bóle mięśni, zatrzymanie wody oraz męczliwość. Średni czas trwania choroby wyniósł 10 lat. Męczliwość, nudności/niestrawność, częste infekcje, bóle kości i stawów, ból brzucha oraz utrata apetytu były skutkami ubocznymi leczenia IKT, które wpływały na zwiększony poziom objawów lękowych. Wiek, długość trwania leczenia oraz płeć w minimalnym zakresie wpływały na występowanie objawów lękowych.WnioskiPraca wskazuje na duże znaczenie występowania skutków ubocznych leczenia IKT dla pojawiania się objawów lękowych. Praca lekarzy, psychologów oraz firm farmaceutycznych nad zmniejszeniem/ złagodzeniem skutków ubocznych może wpłynąć na lepszą jakość życia tych pacjentów. Dodatkowo, prowadzone od kilku lat próby odstawienia leczenia niektórymi IKT (imatynibem i nilotynibem) u pacjentów uzyskujących głęboką odpowiedź molekularną może sprzyjać poprawie ich stanu psychicznego.

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“…As in the case of the other AAs, the absence of Tyr in the human body can be com- Tyr, or L-2-Amino-3-(4-hydroxyphenyl) propanoic acid, a non-essential AA by comparison with Phe and Trypt, is produced naturally in the human body, even from Phe, and through hydroxylation becomes the precursor of two important neurotransmitters of the central nervous system (SNC): adrenaline and noradrenaline-as shown in Figure 1B [67]. As in the case of the other AAs, the absence of Tyr in the human body can be compensated for by consuming various foods (nuts, oat, beans, meat, fish, and wheat) or pharmaceutical products-supplements that have the role of treating PKU and neurological disorders like depression, ADHD, Alzheimer's disease, and mental retardation [61,69,70]. Tyrosinemia and phenylketonuria are diseases that can occur as a result of excess accumulation or an insufficient amount of Tyr in the body [63].…”

Section: Aromaticmentioning

confidence: 99%

A Review of Sensors and Biosensors Modified with Conducting Polymers and Molecularly Imprinted Polymers Used in Electrochemical Detection of Amino Acids: Phenylalanine, Tyrosine, and Tryptophan

Dinu

Apetrei

2022

IJMS

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Recently, the studies on developing sensors and biosensors—with an obvious interdisciplinary character—have drawn the attention of many researchers specializing in various fundamental, but also complex domains such as chemistry, biochemistry, physics, biophysics, biology, bio-pharma-medicine, and bioengineering. Along these lines, the present paper is structured into three parts, and is aimed at synthesizing the most relevant studies on the construction and functioning of versatile devices, of electrochemical sensors and biosensors, respectively. The first part presents examples of the most representative scientific research focusing on the role and the importance of the phenylalanine, tyrosine, and tryptophan amino acids, selected depending on their chemical structure and their impact on the central nervous system. The second part is dedicated to presenting and exemplifying conductor polymers and molecularly imprinted polymers used as sensitive materials in achieving electrochemical sensors and biosensors. The last part of the review analyzes the sensors and biosensors developed so far to detect amino acids with the aid of conductor polymers and molecularly imprinted polymers from the point of view of the performances obtained, with emphasis on the detection methods, on the electrochemical reactions that take place upon detection, and on the electroanalytical performances. The present study was carried out with a view to highlighting, for the benefit of specialists in medicine and pharmacy, the possibility of achieving and purchasing efficient devices that might be used in the quality control of medicines, as well as in studying and monitoring diseases associated with these amino acids.

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Variables associated with self-reported anxiety and depression symptoms in patients with chronic myeloid leukemia receiving tyrosine kinase inhibitor therapy

Cited by 12 publications

References 43 publications

Empathetic nursing with mindful cognitive therapy for fatigue, depression, and negative emotions in leukemia patients undergoing long-term chemotherapy

Empathetic nursing with mindful cognitive therapy for fatigue, depression, and negative emotions in leukemia patients undergoing long-term chemotherapy

Side effects of treatment with tyrosine kinase inhibitors in patients with chronic myeloid leukemia and the occurrence of anxiety symptoms

A Review of Sensors and Biosensors Modified with Conducting Polymers and Molecularly Imprinted Polymers Used in Electrochemical Detection of Amino Acids: Phenylalanine, Tyrosine, and Tryptophan

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