SummaryPacific Northwest National Laboratory has embarked upon a new initiative to strengthen the technical defensibility of and develop a more robust capability to incorporate uncertainty in the groundwater flow and transport model at the U.S. Department of Energy Hanford Site in Southeast Washington State. One aspect of the initiative is developing and using a three-dimensional transient inverse model approach to estimate the hydraulic conductivities, specific yields, and other site-wide scale parameters, including their uncertainties, by using data on the transient behavior of the unconfined aquifer system resulting from Hanford Site waste management since 1943. Over the historical period of Hanford operations, the large volumes of wastewater discharged to a variety of waste facilities resulted in large water table changes over most of the Hanford Site and created significant groundwater mounds (in excess of 20 m) under waste management facilities in the central part of the Site. Since 1988, the mission of the Hanford Site has changed from producing weapons to restoring the environment, and wastewater discharges have declined significantly, which has caused significant water table declines.The three-dimensional transient inverse calibration, which was recommended by an external peer review panel, is being performed using UCODE, a universal inverse modeling code developed jointly by the U.S. Geological Survey and the International Groundwater Modeling Center of the Colorado School of Mines. The work uses the existing consolidated site-wide groundwater model implemented with the Coupled Fluid Energy and Solute Transport code (CFEST), which is the forward model whose parameters are estimated by UCODE. The transient inverse calibration uses over 76,000 water level measurements taken in about 1200 wells at Hanford since the mid 1940s. Because of the long run times and large number of simulations, a serial computational approach for the coupled flow and transport inverse would require a year or more of computational effort. Thus we developed an innovative parallel computational approach that uses an isolated network of 23 computers. The approach uses a recently developed parallel version of UCODE that communicates with a parallel task manager to propagate the multiple simulation tasks (i.e., the forward model runs) for simultaneous computation on the dedicated computers. In addition, a customized version of the forward model code CFEST was developed to simplify the specification of inverse model parameters and the large number of observations. The existing consolidated site-wide groundwater model (referred to as the prior model in this report) was calibrated using 1979 data and a steady-state inverse approach in conjunction with trial and error transient model calibration runs using estimates of artificial discharges and a limited set of representative head observations taken between 1979 and 1996. The conceptual model for the prior model also provided the conceptual basis for the initial three-dimensional transien...