Variable impact of CSF flow suppression on quantitative 3.0T intracranial vessel wall measurements

Cogswell, Petrice M; Siero, Jeroen C.W.; Lants, Sarah K; Waddle, Spencer; Davis, L. Taylor; Gilbert, Guillaume; Hendrikse, Jeroen; Donahue, Manus J.

doi:10.1002/jmri.26028

Cited by 18 publications

(28 citation statements)

References 17 publications

(33 reference statements)

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“…As the changes in wall thickness with age are submillimeter, the changes are often subtle on qualitative inspection. Regardless, at the spatial resolution of recently proposed 3T VWI sequence parameters, quantitative evaluation does demonstrate on average a small increase in wall thickness with age. Scatterplots suggested that the detected vessel wall changes with age were predominantly occurring in subjects greater than 50 years old.…”

Section: Discussionmentioning

confidence: 81%

Vessel wall and lumen characteristics with age in healthy participants using 3T intracranial vessel wall magnetic resonance imaging

Cogswell

Lants

Davis

et al. 2019

Magnetic Resonance Imaging

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Background Intracranial vessel wall imaging (VWI) at a clinical field strength of 3T has become more widely available. However, how vessel measurements change with age and sex, over an age range spanning a typical lifespan, are needed. Purpose/Hypothesis To assess for identifiable changes in arterial wall thickness, outer vessel wall diameter, and lumen diameter with age cross‐sectionally in healthy controls without cerebrovascular disease risk factors at the spatial resolution afforded by currently recommended 3T VWI approaches. Study Type Prospective. Population/Subjects Healthy subjects (n = 82; age = 8–79 years). Field Strength/Sequence 3T intracranial VWI, angiography, and T1‐weighted anatomical imaging. Assessment Two readers measured lumen and outer wall diameters of the supraclinoid internal carotid artery (ICA) and distal basilar artery. Wall thickness and intraclass correlation coefficients (ICCs) were calculated. Statistical Tests Separate linear regressions were performed to understand the relationship between wall measurements (lumen diameter, outer vessel wall diameter, and wall thickness) and age, gender, side (left or right); significance: two‐sided P < 0.05. Results Readers showed excellent agreement for lumen and outer wall diameters (ICC 0.83–094). Linear regression of supraclinoid ICA wall measurements showed a statistically significant increase in wall thickness (P = 0.00051) and outer vessel wall diameter (P = 0.030) with age. ICA lumen and outer vessel wall diameters were statistically greater in males vs. females (lumen diameter 3.69 ± 0.41 vs. 3.54 ± 0.35 mm, P = 0.026; outer wall diameter 5.78 ± 0.52 vs. 5.56 ± 0.44 mm, P = 0.0089) with a trend toward increase in wall thickness (1.05 ± 0.12 vs. 1.01 ± 0.10 mm, P = 0.055). No significant difference was found in basilar artery wall thickness (P = 0.45, P = 0.72), lumen diameter (P = 0.15, P = 0.42), or outer vessel wall diameter (P = 0.34, P = 0.41) with age or gender, respectively. Data Conclusion Intracranial vessel wall measurements were shown to be consistent between readers. At the available spatial resolution of 3T intracranial VWI sequences, supraclinoid ICA vessel wall thickness and outer vessel wall diameter appear to mildly increase with age. There was no detectable change in basilar artery vessel wall characteristics with age. Level of Evidence: 2 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2019;50:1452–1460.

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Section: Discussionmentioning

confidence: 81%

Vessel wall and lumen characteristics with age in healthy participants using 3T intracranial vessel wall magnetic resonance imaging

Cogswell

Lants

Davis

et al. 2019

Magnetic Resonance Imaging

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“…All participants received a non‐contrast 3T brain MRI and an MRA with standard anatomical imaging, including VW‐MRI [3D turbo‐spin‐echo (TSE) factor = 56; TR/TE = 1500/33 ms; refocusing angle sweep = 40°–120°; in‐plane spatial resolution = 0·5 × 0·5 mm], 20,21 T 2 ‐weighted (3D TSE factor = 15; TR/TE = 4000/83 ms; refocusing angle sweep = 40°–120°; spatial resolution = 0·5 × 0·5 × 2·4 mm), fluid‐attenuated inversion recovery (FLAIR; turbo inversion recovery; spatial resolution = 0·6 × 0·6 × 3·0 mm; TR/TI/TE = 11,000/2800/120 ms), diffusion weighted imaging (DWI; single‐shot echo planar imaging; spatial resolution = 1·8 × 1·8 × 4 mm; b‐values of 0 and 1000 s/mm 2 ) and intracranial time‐of‐flight MR angiography (3D gradient echo; spatial resolution = 0·4 × 0·4 × 1·4 mm 3 ; TR/TE = 23/3·5 ms). To evaluate whether vessel wall thickening may be related to flow velocities, we performed phase contrast angiography (PCA) of major anterior and posterior vessels using a previously reported protocol 22 with in‐plane spatial resolution = 0·5 x 0·5 mm 2 , TR/TE = 20/7 ms, v enc = 40 cm/s.…”

Section: Methodsmentioning

confidence: 99%

“…Images were then reformatted in a plane orthogonal to the vessel course (Fig 1) at the following locations: supraclinoid ICA (left and right separately) and mid‐basilar artery between the superior cerebellar artery and anterior inferior cerebellar artery. These segments were the focus of the study, due to the higher established reproducibility of vessel wall thickness measurements in these vessels in non‐atherosclerotic vascular disease patients at the afforded spatial resolution of 3T VW‐MRI, compared with more distal measurements in the middle cerebral arteries 20,21 . Luminal diameters and outer vessel wall diameters were measured perpendicular to the vessel course using the OsiriX multiplanar reformatting tool.…”

Section: Methodsmentioning

confidence: 99%

A cross‐sectional, case‐control study of intracranial arterial wall thickness and complete blood count measures in sickle cell disease

et al. 2020

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Summary In sickle cell disease (SCD), cerebral oxygen delivery is dependent on the cerebral vasculature's ability to increase blood flow and volume through relaxation of the smooth muscle that lines intracranial arteries. We hypothesised that anaemia extent and/or circulating markers of inflammation lead to concentric macrovascular arterial wall thickening, visible on intracranial vessel wall magnetic resonance imaging (VW‐MRI). Adult and pediatric SCD (n = 69; age = 19.9 ± 8.6 years) participants and age‐ and sex‐matched control participants (n = 38; age = 22.2 ± 8.9 years) underwent 3‐Tesla VW‐MRI; two raters measured basilar and bilateral supraclinoid internal carotid artery (ICA) wall thickness independently. Mean wall thickness was compared with demographic, cerebrovascular and haematological variables. Mean vessel wall thickness was elevated (P < 0·001) in SCD (1·07 ± 0·19 mm) compared to controls (0·97 ± 0·07 mm) after controlling for age and sex. Vessel wall thickness was higher in participants on chronic transfusions (P = 0·013). No significant relationship between vessel wall thickness and flow velocity, haematocrit, white blood cell count or platelet count was observed; however, trends (P < 0·10) for wall thickness increasing with decreasing haematocrit and increasing white blood cell count were noted. Findings are discussed in the context of how anaemia and circulating inflammatory markers may impact arterial wall morphology.

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“…31 In many cases, these VWI studies need confirmation with additional work to show reproducibility and validity in various patient populations if these findings are to be used to heavily influence clinical care. Readers should take into account spatial resolution and type of flow-suppression technique, as these technical factors can impact the appearance of vessel wall 12 and vessel wall enhance- ment. Additionally, the methods of image interpretation and criteria used to establish the final diagnosis need careful consideration.…”

Section: High-resolution Vessel Wall Imagingmentioning

confidence: 99%

Contemporary and emerging magnetic resonance imaging methods for evaluation of moyamoya disease

Lehman¹,

Cogswell²,

Rinaldo³

et al. 2019

Neurosurgical Focus

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Numerous recent technological advances offer the potential to substantially enhance the MRI evaluation of moyamoya disease (MMD). These include high-resolution volumetric imaging, high-resolution vessel wall characterization, improved cerebral angiographic and perfusion techniques, high-field imaging, fast scanning methods, and artificial intelligence. This review discusses the current state-of-the-art MRI applications in these realms, emphasizing key imaging findings, clinical utility, and areas that will benefit from further investigation. Although these techniques may apply to imaging of a wide array of neurovascular or other neurological conditions, consideration of their application to MMD is useful given the comprehensive multidimensional MRI assessment used to evaluate MMD. These MRI techniques span from basic cross-sectional to advanced functional sequences, both qualitative and quantitative.The aim of this review was to provide a comprehensive summary and analysis of current key relevant literature of advanced MRI techniques for the evaluation of MMD with image-rich case examples. These imaging methods can aid clinical characterization, help direct treatment, assist in the evaluation of treatment response, and potentially improve the understanding of the pathophysiology of MMD.

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Variable impact of CSF flow suppression on quantitative 3.0T intracranial vessel wall measurements

Abstract: 2 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;48:1120-1128.

Cited by 18 publications

References 17 publications

Vessel wall and lumen characteristics with age in healthy participants using 3T intracranial vessel wall magnetic resonance imaging

Vessel wall and lumen characteristics with age in healthy participants using 3T intracranial vessel wall magnetic resonance imaging

A cross‐sectional, case‐control study of intracranial arterial wall thickness and complete blood count measures in sickle cell disease

Contemporary and emerging magnetic resonance imaging methods for evaluation of moyamoya disease

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