Variable frequency stimulation of subthalamic nucleus for freezing of gait in Parkinson's disease

Jia, Fumin; Guo, Yi; Wan, Sen; Chen, Hao; Hao, Hongwei; Zhang, Jianguo; Li, Luming

doi:10.1016/j.parkreldis.2015.10.002

Cited by 32 publications

(34 citation statements)

References 5 publications

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“…Variable frequency stimulation (VFS) involves alternating HFS with LFS. Jia et al [ 23 ] proposed that VFS may serve as an effective strategy for treating FOG and axial symptoms in PD patients while maintaining optimal treatment of appendicular symptoms. This was exemplified in a case of one PD patient with FOG who improved with VFS.…”

Section: Update On Stimulationmentioning

confidence: 99%

Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease

Paff

Loh

Sarica

et al. 2020

JMD

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Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson’s disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.

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Section: Update On Stimulationmentioning

confidence: 99%

Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease

Paff

Loh

Sarica

et al. 2020

JMD

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“…Afterward, he was evaluated for possible VNS therapy in our epilepsy center, in order to relieve the seizure condition. A VNS device (PINS Medical, 23 , 24 Figure 2 ) was subsequently implanted 1 year after the surgical resection. The stimulator was activated at 0.5 mA, 30 Hz, 500 μs, 30 seconds on, 5 minutes off 2 weeks after the day of surgery, and the amplitude was increased to 0.75 mA during the first month after implantation.…”

Section: Case Reportmentioning

confidence: 99%

Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient

Wang¹,

Chai²,

Qiao³

et al. 2016

NDT

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IntroductionIn recent years, treatment of intractable epilepsy has become more challenging, due to an increase in resistance to antiepileptic drugs, as well as diminished success following resection surgery. Here, we present the case of a 19-year old epileptic patient who received vagus nerve stimulation (VNS) following unsuccessful left parietal–occipital lesion-resection surgery, with results indicating an approximate 50% reduction in seizure frequency and a much longer seizure-free interictal phase.Materials and methodsUsing resting-state functional magnetic resonance imaging, we measured the changes in resting-state brain networks between pre-VNS treatment and 6 months post-VNS, from the perspective of regional and global variations, using regional homogeneity and large-scale functional connectives (seeding posterior cingulate cortex and anterior cingulate cortex), respectively.ResultsAfter 6 months of VNS therapy, the resting-state brain networks were slightly reorganized in regional homogeneity, mainly in large-scale functional connectivity, where excessive activation of the salience network was suppressed, while at the same time the suppressed default-mode network was activated.ConclusionWith regard to resting-state brain networks, we propose a hypothesis based on this single case study that VNS acts on intractable epilepsy by modulating the balance between salience and default-mode networks through the integral hub of the anterior cingulate cortex.

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“…However, beneficial effects could not always be reproduced, and low-frequency stimulation sometimes led to worsening of cardinal PD symptoms. [87][88][89] The effect of variable frequency stimulation, a paradigm interleaving high-and low-frequency DBS, 90 will be explored soon. 91 Also, pulse-width modulation might provide clinical benefit in certain situations.…”

Section: Adbs Modulation Other Than Amplitude Modulationmentioning

confidence: 99%

An update on adaptive deep brain stimulation in Parkinson's disease

et al. 2018

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Advancing conventional open‐loop DBS as a therapy for PD is crucial for overcoming important issues such as the delicate balance between beneficial and adverse effects and limited battery longevity that are currently associated with treatment. Closed‐loop or adaptive DBS aims to overcome these limitations by real‐time adjustment of stimulation parameters based on continuous feedback input signals that are representative of the patient's clinical state. The focus of this update is to discuss the most recent developments regarding potential input signals and possible stimulation parameter modulation for adaptive DBS in PD. Potential input signals for adaptive DBS include basal ganglia local field potentials, cortical recordings (electrocorticography), wearable sensors, and eHealth and mHealth devices. Furthermore, adaptive DBS can be applied with different approaches of stimulation parameter modulation, the feasibility of which can be adapted depending on specific PD phenotypes. Implementation of technological developments like machine learning show potential in the design of such approaches; however, energy consumption deserves further attention. Furthermore, we discuss future considerations regarding the clinical implementation of adaptive DBS in PD. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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Variable frequency stimulation of subthalamic nucleus for freezing of gait in Parkinson's disease

Cited by 32 publications

References 5 publications

Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease

Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease

Vagus nerve stimulation balanced disrupted default-mode network and salience network in a postsurgical epileptic patient

An update on adaptive deep brain stimulation in Parkinson's disease

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