Variable Findings for Drug‐Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine

Capasso, Robson; Rosa, Talita D’Aguiar; Tsou, David Yung-An; Nekhendzy, Vladimir; Drover, David R.; Collins, Jeremy; Zaghi, Soroush; Camacho, Macario

doi:10.1177/0194599815625972

Cited by 63 publications

(50 citation statements)

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“…Clinically and statistically significant differences were observed in complete and partial concentric collapses, especially at the level of the velum, and partial collapse at the level of the oropharynx, tongue, and epiglottis. In previous studies, Capasso et al [18] and Yoon et al [10] observed important findings in terms of modified anatomic structures in velum, tongue, and epiglottis, but not such significant changes in the oropharynx, which is consistent with our own findings.…”

Section: Discussionsupporting

confidence: 93%

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Retrospective-comparative study of patients with obstructive sleep apneas and hypopneas in awake endoscopy and drug induced sleep endoscopy

Rabino¹,

Bustamante²,

Ricardo³

2017

Otorhinolaryngol Head Neck Sur

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Section: Discussionsupporting

confidence: 93%

“…However, there are multiple Asian and European studies on the use of DISE [18,19], in this study, DISE is presented as a useful tool to facilitate the assessment of vibration and collapse in OSA patients. According to a literature review, this is the only study conducted in Argentina with DISE and VOTE classification to report results.…”

Section: Discussionmentioning

confidence: 99%

Retrospective-comparative study of patients with obstructive sleep apneas and hypopneas in awake endoscopy and drug induced sleep endoscopy

Rabino¹,

Bustamante²,

Ricardo³

2017

Otorhinolaryngol Head Neck Sur

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“…Propofol has been demonstrated to produce a higher incidence of apnea, with a duration >30 sec, which exposes the patient to the risks of a decrease in SpO 2 (43). As brain damage related to respiratory events is the leading cause of morbidity Table IV.…”

Section: Discussionmentioning

confidence: 99%

“…in anesthesia-related events, the safety of anesthesia is critical. Research has demonstrated that propofol is associated with a 9.7% incidence of apnea (44,45).…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study

Tang

Liu

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The aim of the present study was to evaluate the safety and efficacy of various general anesthesia regimens during endoscopic variceal ligation (EVL) and endoscopic variceal sclerotherapy (EVS). A total of 123 patients with American Society of Anesthesiologists physical status III and IV, aged 40-70 years, undergoing general anesthesia for EVL and EVS were randomly divided into two groups: Sevoflurane anesthesia (group S; n=60) and propofol anesthesia (group P; n=60). Vital signs, particularly heart rate (HR) and mean arterial pressure (MAP), were monitored. The designated time points were as follows: 5 min before induction (T0), and 1, 5, 10, 15, 20, 25 and 30 min after intubation (T1, T2, T3, T4, T5, T6 and T7, respectively). Time intervals were recorded, including recovery time and extubation time. Following surgery, the observer recorded the Ramsay sedation scale (RSS) score and the visual analogue scale (VAS) score. Adverse reactions were noted. Results demonstrated that there were significant differences in MAP between the two groups at T2, T3, T5, T6 and T7 (P<0.05). There was a significant difference in HR between the two groups at T2, T3 and T4 (P<0.05). Recovery time and extubation time in group P were significantly longer than those in group S (P<0.05; 18.38±2.25 min vs. 14.57±1.04 min and 21.70±2.70 min vs. 15.83±0.88 min, respectively). The rate of ephedrine injected was 58.3% (35/60 patients) in group P vs. 28.3% (17/60 patients) in group S (P<0.05). There was a significant difference in the RSS score between the two groups 5 min after extubation (P<0.05). VRS scores demonstrated that anesthetists and patients were significantly more satisfied with the procedure in group S than in group P (P<0.01). In conclusion, the superiority and special clinical value of inhalational anesthesia has been demonstrated during EVL and EVS attributed to stable hemodynamics and high quality of anesthesia recovery in the present study.

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“…Another study by Capasso et al [8] found that the use of propofol was associated with greater incidence of complete anteroposterior tongue base collapse. This finding may be attributed to the increased collapsibility of the upper airway due to profound relaxation of genioglossus muscle [9].…”

Section: Discussionmentioning

confidence: 96%

Ideal Drug for Frug Induced Sleep Endoscopy, Protocol Vs Dexmedetomidine- Systematic Review

Mohammed¹

2016

GJO

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Drug induced sleep endoscopy is the most important investigation before surgical planning of obstructive sleep apnea patient. It is performed by artificially inducing sleep in a patient and performing nasal endoscopy in order to identify the site of upper airway obstruction. The most appropriate anesthetic agent would be that which induces sleep without any respiratory inhibition. Propofol has been widely used to perform drug induced sleep endoscopy. However, Dexmedetomidine is a newer drug which has shown to have many advantages making it suitable to drug induced nasal endoscopy. The present study is a systematic review of English literature which compares the utility of Propofol and dexmedetomidine in drug induced sleep endoscopy.

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Variable Findings for Drug‐Induced Sleep Endoscopy in Obstructive Sleep Apnea with Propofol versus Dexmedetomidine

Abstract: Use of propofol versus dexmedetomidine to induce sedation may have a significant effect on the pattern of upper airway obstruction observed during DISE. Randomized prospective studies are indicated to confirm these initial findings.

Cited by 63 publications

References 50 publications

Retrospective-comparative study of patients with obstructive sleep apneas and hypopneas in awake endoscopy and drug induced sleep endoscopy

Retrospective-comparative study of patients with obstructive sleep apneas and hypopneas in awake endoscopy and drug induced sleep endoscopy

Sevoflurane may be more beneficial than propofol in patients receiving endoscopic variceal ligation and endoscopic variceal sclerotherapy: A randomized, double-blind study

Ideal Drug for Frug Induced Sleep Endoscopy, Protocol Vs Dexmedetomidine- Systematic Review

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