Abstract:The capacities of human acute myeloid leukaemia (AML) cells for differentiation were evaluated by the degree of maturation of cells following in vitro colony formation. For this purpose highly purified blast cells were seeded into culture. Exogenous differentiation inducers, other than the colony stimulating materials, were not added to the cultures. Phenotypes of the colony cells were determined by use of monoclonal antibodies directed against a number of maturation antigens. In all 10 cases marked changes in… Show more
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