Variable antifungal activity of curcumin against planktonic and biofilm phase of different candida species

Narayanan, Vasumathi; Muddaiah, Sunil; Raju, Shashidara; Sudheendra, Udyavara Sridhara; Deepthi, N C; Samaranayake, LP

doi:10.4103/ijdr.ijdr_521_17

Cited by 13 publications

(9 citation statements)

References 2 publications

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“…These findings consist of a recently reported study, which emphasises that an increase in curcumin dose results in increased antibacterial activity [32]. Results of the previous study imply that the antifungal activity of curcumin against C. albicans generally increases by increasing the dose [33].However, investigation of antifungal activity is restricted to only one positive control and it is mandatory to conduct further research on a wider range of fungi. A recent study by Narayanan et al [34] revealed the variable antifungal activity of curcumin against planktonic and biofilm phase of different Candida species and therefore implied that curcumin could be considered a therapeutic alternative to conventional antifungals [34].…”

Section: In Vitro Antimicrobial Activitymentioning

confidence: 56%

Curcumin: Natural Antimicrobial and Anti Inflammatory Agent

Pehlivanović

Čaklovica

Lagumdžija

et al. 2021

JPRI

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The pursuance of novel antimicrobial and anti-inflammatory agents has been expanding due to a significant need for more efficient pharmacotherapy of various infections and chronic diseases. During the last decade, pharmacokinetics, pharmacodynamics and pharmacological properties of curcumin have been extensively studied. The aim of the present study was to evaluate the antibacterial activity of curcumin against both Gram-positive and Gram-negative bacteria as well as its antifungal activity by using in vitro agar well diffusion assay. Moreover, the anti-inflammatory activity of curcumin was determined with in vitro assay of inhibition of protein denaturation. Results demonstrated wide antimicrobial activity of curcumin upon all of the test bacteria and fungi. The strongest activity of curcumin was observed at a concentration of 0.50 mg/ml against S. aureus, L. monocytogenes, E. coli, P. aeruginosa and C. albicans, resulting in a maximum zone of inhibition of 14.7 mm, 14.3 mm, 13.7 mm, 10.7 mm and 10.7 mm, respectively. Findings suggested that the antimicrobial activity of curcuminis dependent upon the concentrations. Furthermore, results demonstrated high effectiveness of curcumin compared to standard acetylsalicylic acid in inhibiting heat-induced protein denaturation, which activity is also depended upon the concentrations. The present study emphasises the potential application of curcumin as a natural antimicrobial and anti-inflammatory agent. However, findings of this study are restricted to in vitro assays and consideration should be given to conducting a study involving wider dose range test substances as well as including further research on in vivo models.

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Section: In Vitro Antimicrobial Activitymentioning

confidence: 56%

Curcumin: Natural Antimicrobial and Anti Inflammatory Agent

Pehlivanović

Čaklovica

Lagumdžija

et al. 2021

JPRI

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“…In the case of C. glabrata and C. tropicalis , curcumin was inactive at concentrations tested (MIC > 5000 µg/mL), while for S. cerevisiae the MIC was 5000 µg/mL. Recent studies of Narayanan et al [ 63 ] have shown the activity of curcumin against C. albicans ATCC 90028 and C. glabrata ATCC 90030 at the level of 500 µg/mL, whereas for the clinical isolate of C. albicans it was 2000 µg/mL. The differences between ATCC and clinical strains of yeast-like fungi were also reported in the earlier work of Neelofar et al [ 64 ].…”

Section: Discussionmentioning

confidence: 99%

“…No differentiation in this respect was found in two strains of C. glabrata : ATCC 90030 and a cutaneous clinical isolate (MIC = 500 µg/mL). According to the authors cited above [ 63 ], the greater sensitivity of standard Candida strains is caused by the suppression of virulence factors during a repeated subculture of the laboratory strains. This regularity has been also exhibited for some bacteria [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

2020

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Curcumin, a principal bioactive substance of turmeric (Curcuma longa L.), is reported as a strong antioxidant, anti-inflammatory, antibacterial, antifungal, and antiviral agent. However, its antimicrobial properties require further detailed investigations into clinical and multidrug-resistant (MDR) isolates. In this work, we tested curcumin’s efficacy against over 100 strains of pathogens belonging to 19 species. This activity was determined by the broth microdilution method and by calculating the minimum inhibitory concentration (MIC). Our findings confirmed a much greater sensitivity of Gram-positive than Gram-negative bacteria. This study exhibited a significantly larger variation in the curcumin activity than previous works and suggested that numerous clinical strains of widespread pathogens have a poor sensitivity to curcumin. Similarly, the MICs of the MDR types of Staphylococcus aureus, S. haemolyticus, Escherichia coli, and Proteus mirabilis were high (≥2000 µg/mL). However, curcumin was effective against some species and strains: Streptococcus pyogenes (median MIC = 31.25 µg/mL), methicillin-sensitive S. aureus (250 µg/mL), Acinetobacter lwoffii (250 µg/mL), and individual strains of Enterococcus faecalis and Pseudomonas aeruginosa (62.5 µg/mL). The sensitivity of species was not associated with its affiliation to the genus, and it could differ a lot (e.g., S. pyogenes, S. agalactiae and A. lwoffii, A. baumannii). Hence, curcumin can be considered as a promising antibacterial agent, but with a very selective activity.

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“…Curcumin, a multi-targeted compound, has traditionally been used as a dietary spice and a medicinal herb in Asian countries for a variety of pathologies due to its anti-inflammatory properties [ 34 ], and antioxidant properties [ 35 , 36 ]. Moreover, curcumin possesses antibacterial [ 37 ], antiviral [ 38 ], antifungal [ 39 ], anti-arthritic [ 40 ], hepatoprotective [ 41 ], anti-thrombotic [ 42 ], cardio-protective [ 43 ], hypoglycemic [ 44 ], anti-allergic [ 45 , 46 ], wound-healing [ 47 ], and chemo-preventive and anticancer properties [ 48 , 49 , 50 ]. Curcumin’s anti-inflammatory and antioxidant effects, among others, form the basis of curcumin’s critical neuroprotective effects in a variety of neurological diseases affecting both the central and peripheral nervous systems.…”

Section: Curcumin As a Potential Neuroprotective Agentmentioning

confidence: 99%

Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

Nebrisi

2021

IJMS

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Parkinson’s disease (PD) is a slowly progressive multisystem disorder affecting dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized by a decrease of dopamine (DA) in their striatal terminals. Treatment of PD with levodopa or DA receptor agonists replaces the function of depleted DA in the striatum. Prolonged treatment with these agents often has variable therapeutic effects and leads to the development of undesirable dyskinesia. Consequently, a crucial unmet demand in the management of Parkinson’s disease is the discovery of new approaches that could slow down, stop, or reverse the process of neurodegeneration. Novel potential treatments involving natural substances with neuroprotective activities are being developed. Curcumin is a polyphenolic compound isolated from the rhizomes of Curcuma longa (turmeric). It has been demonstrated to have potent anti-inflammatory, antioxidant, free radical scavenging, mitochondrial protecting, and iron-chelating effects, and is considered a promising therapeutic and nutraceutical agent for the treatment of PD. However, molecular and cellular mechanisms that mediate the pharmacological actions of curcumin remain largely unknown. Stimulation of nicotinic receptors and, more precisely, selective α7 nicotinic acetylcholine receptors (α7-nAChR), have been found to play a major modulatory role in the immune system via the “cholinergic anti-inflammatory pathway”. Recently, α7-nAChR has been proposed to be a potential therapeutic approach in PD. In this review, the detailed mechanisms of the neuroprotective activities of curcumin as a potential therapeutic agent to help Parkinson’s patients are being discussed and elaborated on in detail.

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Variable antifungal activity of curcumin against planktonic and biofilm phase of different candida species

Cited by 13 publications

References 2 publications

Curcumin: Natural Antimicrobial and Anti Inflammatory Agent

Curcumin: Natural Antimicrobial and Anti Inflammatory Agent

Curcumin, a Natural Antimicrobial Agent with Strain-Specific Activity

Neuroprotective Activities of Curcumin in Parkinson’s Disease: A Review of the Literature

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