Variability of the <scp>L</scp>‐Histidine decarboxylase gene in allergic rhinitis

Gervasini, Guillermo; Agúndez, José A. G.; García-Menaya, Jesús Miguel; Martı́nez, Carmen; Cordobés, Concepción; Ayuso, Pedro; Cornejo, J. A.; Blanca, Miguel; García‐Martín, Elena

doi:10.1111/j.1398-9995.2010.02425.x

Cited by 27 publications

(25 citation statements)

References 25 publications

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“…Polymorphisms in the HDC and SLC22A3 genes influenced the risk of both rhinitis and asthma [19]. The association of asthma with HNMT SNP could not be observed in two Caucasian (Spanish and German) and an Indian population [20,21,22].…”

Section: Discussionmentioning

confidence: 99%

Asthma Endophenotypes and Polymorphisms in the Histamine Receptor HRH4 Gene

Simon

Semsei²,

Ungvári³

et al. 2012

Int Arch Allergy Immunol

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Background: Histamine as an inflammatory mediator plays an important role in chronic allergic and asthmatic conditions. However, the role of genetic polymorphisms of the histamine receptor HRH4 (histamine receptor H4) gene in asthma susceptibility and endophenotypes has not been studied yet. Our aim was to investigate the possible association between single nucleotide polymorphisms (SNPs) in the HRH4 gene and asthma or some endophenotypes of asthma. Methods: Twenty-one SNPs of the HRH4 gene were genotyped in 313 asthmatic patients and 360 controls using Sequenom® iPLEX® Gold Genotyping Technology. Results: Genotype distribution of three HRH4 SNPs, namely rs17187619 [p = 0.002; odds ratio, OR (95% confidence interval, CI) = 2.4 (4.1–1.4)], rs527790 [p = 0.0002; OR (95% CI) = 3.3 (6.1–1.8)] and rs487202 [p = 0.00007; OR (95% CI) = 3.5 (6.6–1.9)] differed significantly between patients with or without infection-induced asthma. Haplotypes, which included the rs4800573–rs527790 CC allele combination, were found to be associated with infection-induced asthma [p = 0.0009, OR (95% CI) = 0.5 (0.4–0.8)]. The rs487202–rs574913 CA haplotype was more frequent among patients with infection-induced asthma [p = 0.0006, OR (95% CI) = 1.9 (1.3–2.6)]. None of the SNPs contributed directly to the risk of asthma. Conclusions: Our results suggest that genetic variation in the HRH4 gene might influence the pathogenesis of infection-induced asthma.

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Section: Discussionmentioning

confidence: 99%

Asthma Endophenotypes and Polymorphisms in the Histamine Receptor HRH4 Gene

Simon

Semsei²,

Ungvári³

et al. 2012

Int Arch Allergy Immunol

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“…Variability in the genes related to histamine homeostasis has been implicated in allergic disorders [55,56]. The histamine Nmethyltransferase 939A>G polymorphism has been shown to be associated with NECD, potentially decreasing mRNA stability, causing reduced enzyme activity and increased cellular histamine [57].…”

Section: Immunoglobulin E Receptor Histamine Homeostasis-related Genmentioning

confidence: 99%

Genetic basis of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

Gómez

Perkins²,

García‐Martín³

et al. 2015

Current Opinion in Allergy &Amp; Clinical Immunology

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The full genetic and molecular basis of clinical entities induced by NSAIDs hypersensitivity has yet to be uncovered, and despite commendable efforts over recent years, no clinically proven genetic markers currently exist for these disorders. It is clear that we will continue to find more about these reactions in the coming years, concurrently with improvements in technology and experimental techniques, and a precise definition of different phenotypes.

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“…Three other SNPs have also been investigated within the pathway which also result in differences in enzyme function (ABP1 47 C/T, ABP1 995 C/T, and ABP1 4107C/G). Although the functional significance of many identified SNPs within the pathway is unknown, several studies have been conducted to explore potential associations between histamine related genes and asthma and allergic disease which have yielded mixed results (5,(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, previous studies have often been conducted among undefined asthma phenotypes and typically only included SNPs within single genes.…”

Section: Introductionmentioning

confidence: 95%

Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma

Anvari

Vyhlidal

Dai

et al. 2015

Am J Respir Cell Mol Biol

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Histamine is an important mediator in the pathogenesis of asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that differences exist among single-nucleotide polymorphisms (SNPs) in genes of the histamine pathway between children with allergic versus nonallergic asthma. Children (7-18 yr of age; n = 202) with asthma were classified as allergic or nonallergic based on allergy skin testing. Genotyping was performed to detect known SNPs (n = 10) among genes (HDC, HNMT, ABP1, HRH1, and HRH4) within the histamine pathway. Chi square tests and Cochran-Armitage Trend were used to identify associations between genetic variants and allergic or nonallergic asthma. Significance was determined by P < 0.05 and false-positive report probability. After correction for race differences in genotype were observed, HRH1-17 TT (6% allergic versus 0% nonallergic; P = 0.04), HNMT-464 TT (41% allergic versus 29% nonallergic; P = 0.04), and HNMT-1639 TT (30% allergic versus 20% nonallergic; P = 0.04) were overrepresented among children with allergic asthma. Genotype differences specifically among the African-American children were also observed: HRH1-17 TT (13% allergic versus 0% nonallergic; P = 0.04) and HNMT-1639 TT (23% allergic versus 3% nonallergic; P = 0.03) genotypes were overrepresented among African-American children with allergic asthma. Our study suggests that genetic variation within the histamine pathway may be associated with an allergic versus nonallergic asthma phenotype. Further studies are needed to determine the functional significance of identified SNPs and their impact on antihistamine response in patients with asthma and allergic disease.

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Variability of the L‐Histidine decarboxylase gene in allergic rhinitis

Abstract: The HDC allele Glu644 in homozygosity increases the risk of developing rhinitis in the studied population. This adds to increasing evidence supporting a prominent role of genetic variations related to histamine homeostasis in the risk to develop allergic diseases.

Cited by 27 publications

References 25 publications

Asthma Endophenotypes and Polymorphisms in the Histamine Receptor <b><i>HRH4</i></b> Gene

Asthma Endophenotypes and Polymorphisms in the Histamine Receptor <b><i>HRH4</i></b> Gene

Genetic basis of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs

Genetic Variation along the Histamine Pathway in Children with Allergic versus Nonallergic Asthma

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