Variability of MRI Aortic Stiffness Measurements in a Multicenter Clinical Trial Setting: Intraobserver, Interobserver, and Intracenter Variability of Pulse Wave Velocity and Aortic Strain Measurement

Paar, Maja Hrabak; Kircher, Achim; Sayari, Saeed Al; Kopp, Sebastién; Santini, Francesco; Schmieder, Roland E.; Kachenoura, Nadjia; Yates, Denise; Langenickel, Thomas; Bremerich, Jens; Heye, Tobias

doi:10.1148/ryct.2020190090

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…[ 23 ] However, the disadvantages of this method include that its methodology has not yet been standardized,[ 22 ] it is expensive, not easily accessible,[ 24 ] and the variability in MRI aortic stiffness measurements. [ 25 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of aortic stiffness by transthoracic echocardiographic in young COVID-19 patients

Mansıroğlu

Disikirik

Seymen

et al. 2022

J Cardiovasc Echography

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Section: Discussionmentioning

confidence: 99%

Assessment of aortic stiffness by transthoracic echocardiographic in young COVID-19 patients

Mansıroğlu

Disikirik

Seymen

et al. 2022

J Cardiovasc Echography

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“…Biomarkers of longitudinal and circumferential deformation have been shown to be inversely related to PWV. 6 , 14 , 63 , 66 , 67 By MRI, intra‐ and interobserver reproducibility were acceptable 28 or high, 63 , 64 , 66 and scan‐rescan acceptable 28 for distensibility in the thoracic aorta as well as for longitudinal deformation of the proximal aorta. 11 Given the similarity in assessment, these results should translate to circumferential strain assessment as well.…”

Section: Biomarkers Of Aortic Agingmentioning

confidence: 90%

“…Many studies tested intra‐ and inter‐observer reproducibility and mostly reported good‐to‐excellent results. Reproducibility tests are available for Fourier‐encoded data, 3 , 22 2D PC with both in‐ and through‐plane velocity encoding 2 , 4 , 8 , 9 , 13 , 25 , 28 and for 4D flow. 14 , 19 , 20 , 29 Scan‐rescan (ie, test–retest, inter‐scan) reproducibility was good or moderate by 2D PC, 13 , 28 4D flow 20 and Fourier‐encoded data.…”

Section: Biomarkers Of Aortic Agingmentioning

confidence: 99%

“…Reproducibility tests are available for Fourier‐encoded data, 3 , 22 2D PC with both in‐ and through‐plane velocity encoding 2 , 4 , 8 , 9 , 13 , 25 , 28 and for 4D flow. 14 , 19 , 20 , 29 Scan‐rescan (ie, test–retest, inter‐scan) reproducibility was good or moderate by 2D PC, 13 , 28 4D flow 20 and Fourier‐encoded data. 22 Notably, the impact of the accuracy and reproducibility of traveling distance on the obtained PWV was reported to be limited.…”

Section: Biomarkers Of Aortic Agingmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action

Bianchini

Lønnebakken

Wohlfahrt

et al. 2023

JAHA

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Magnetic resonance imaging and computed tomography allow the characterization of arterial state and function with high confidence and thus play a key role in the understanding of arterial aging and its translation into the clinic. Decades of research into the development of innovative imaging sequences and image analysis techniques have led to the identification of a large number of potential biomarkers, some bringing improvement in basic science, others in clinical practice. Nonetheless, the complexity of some of these biomarkers and the image analysis techniques required for their computation hamper their widespread use. In this narrative review, current biomarkers related to aging of the aorta, their founding principles, the sequence, and postprocessing required, and their predictive values for cardiovascular events are summarized. For each biomarker a summary of reference values and reproducibility studies and limitations is provided. The present review, developed in the COST Action VascAgeNet, aims to guide clinicians and technical researchers in the critical understanding of the possibilities offered by these advanced imaging modalities for studying the state and function of the aorta, and their possible clinically relevant relationships with aging.

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“…Despite all the advantages, ultrasound-based PWV measurements also entail some detrimental characteristics like the error-prone distance measurements [ 109 ]. Therefore—especially in comparison to MRI—ultrasound is very user-dependent [ 110 ]. In addition, ultrasound has a limited penetration depth, making some vessels difficult to reach.…”

Section: Arterial Wall Stiffness In Atherosclerosismentioning

confidence: 99%

Evaluation of Plaque Characteristics and Inflammation Using Magnetic Resonance Imaging

et al. 2021

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Atherosclerosis is an inflammatory disease of large and medium-sized arteries, characterized by the growth of atherosclerotic lesions (plaques). These plaques often develop at inner curvatures of arteries, branchpoints, and bifurcations, where the endothelial wall shear stress is low and oscillatory. In conjunction with other processes such as lipid deposition, biomechanical factors lead to local vascular inflammation and plaque growth. There is also evidence that low and oscillatory shear stress contribute to arterial remodeling, entailing a loss in arterial elasticity and, therefore, an increased pulse-wave velocity. Although altered shear stress profiles, elasticity and inflammation are closely intertwined and critical for plaque growth, preclinical and clinical investigations for atherosclerosis mostly focus on the investigation of one of these parameters only due to the experimental limitations. However, cardiovascular magnetic resonance imaging (MRI) has been demonstrated to be a potent tool which can be used to provide insights into a large range of biological parameters in one experimental session. It enables the evaluation of the dynamic process of atherosclerotic lesion formation without the need for harmful radiation. Flow-sensitive MRI provides the assessment of hemodynamic parameters such as wall shear stress and pulse wave velocity which may replace invasive and radiation-based techniques for imaging of the vascular function and the characterization of early plaque development. In combination with inflammation imaging, the analyses and correlations of these parameters could not only significantly advance basic preclinical investigations of atherosclerotic lesion formation and progression, but also the diagnostic clinical evaluation for early identification of high-risk plaques, which are prone to rupture. In this review, we summarize the key applications of magnetic resonance imaging for the evaluation of plaque characteristics through flow sensitive and morphological measurements. The simultaneous measurements of functional and structural parameters will further preclinical research on atherosclerosis and has the potential to fundamentally improve the detection of inflammation and vulnerable plaques in patients.

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Variability of MRI Aortic Stiffness Measurements in a Multicenter Clinical Trial Setting: Intraobserver, Interobserver, and Intracenter Variability of Pulse Wave Velocity and Aortic Strain Measurement

Cited by 9 publications

References 25 publications

Assessment of aortic stiffness by transthoracic echocardiographic in young COVID-19 patients

Assessment of aortic stiffness by transthoracic echocardiographic in young COVID-19 patients

Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action

Evaluation of Plaque Characteristics and Inflammation Using Magnetic Resonance Imaging

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