Abstract:Human ribosomal DNA is represented by hundreds of repeats in each cell. Every repeat consists of two parts: a 13 kb long 47S DNA with genes encoding 18S, 5.8S, and 28S RNAs of ribosomal particles, and a 30 kb long intergenic spacer (IGS). Remarkably, transcription does not take place in all the repeats. The transcriptionally silent genes are characterized by the epigenetic marks of the inactive chromatin, including DNA hypermethylation of the promoter and adjacent areas. However, it is still unknown what cause… Show more
“…This Special Issue is concluded by two experimental papers describing how DNA methylation can be a source of variability in the expression of rRNA genes [26] and how codon bias can be a triggering factor for the accumulation of specific mRNAs into stress bodies in yeast [27]. Both articles are prime examples of how genomic variability can alter the structure and function of RNA regulatory networks.…”
The central role of RNA molecules in cell biology has been an expanding subject of study since the proposal of the “RNA world” hypothesis 60 years ago [...]
“…This Special Issue is concluded by two experimental papers describing how DNA methylation can be a source of variability in the expression of rRNA genes [26] and how codon bias can be a triggering factor for the accumulation of specific mRNAs into stress bodies in yeast [27]. Both articles are prime examples of how genomic variability can alter the structure and function of RNA regulatory networks.…”
The central role of RNA molecules in cell biology has been an expanding subject of study since the proposal of the “RNA world” hypothesis 60 years ago [...]
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