Variability of (functional) hemodynamics as measured with simultaneous fNIRS and fMRI during intertemporal choice

Heinzel, Sebastian; Haeußinger, Florian B.; Hahn, Tim; Ehlis, Ann‐Christine; Plichta, Michael M.; Fallgatter, Andreas J.

doi:10.1016/j.neuroimage.2012.12.074

Cited by 94 publications

(89 citation statements)

References 37 publications

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“…A total of 23 channels were recorded in this study. Channels were co-registered into three PFC scalp quadrants (Frontopolar area (FPA): Ch- [9-11, 15, 16, 20-22], Ventrolateral prefrontal area (VLPFC): Ch- [8,13,14,19,12,17,18,23] and Dorsolateral prefrontal area (DLPFC): Ch- [1][2][3][4][5][6][7]), and sub-divided into left and right hemispheres. The sampling frequency for the fNIRS system was 10 Hz.…”

Section: Measurement Setupmentioning

confidence: 99%

“…The fNIRS offers sub-second temporal resolution and spatial resolution in cm [15], and has shown its potential in localizing task activations similarly to fMRI [16][17][18]; meanwhile, EEG can measure cortical activity with temporal resolution in milliseconds, and has been used in the studies about emotional states, workload and fatigue [19][20][21][22]. Due to their complementary nature, fusion of fNIRS and EEG may yield richer information about the cortical activities in our study.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of mental stress effects on prefrontal cortical activities using canonical correlation analysis: an fNIRS-EEG study

Al-Shargie¹,

Tang²,

Kiguchi³

2017

Biomed. Opt. Express

108

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This paper presents an investigation about the effects of mental stress on prefrontal cortex (PFC) subregions using simultaneous measurement of functional Near-Infrared Spectroscopy (fNIRS) and Electroencephalography (EEG) signals. The aim is to explore canonical correlation analysis (CCA) technique to study the relationship among the bimodality signals in mental stress assessment, and how we could fuse the signals for better accuracy in stress detection. Twenty-five male healthy subjects participated in the study while performing mental arithmetic task under control and stress (under time pressure with negative feedback) conditions. The fusion of brain signals acquired by fNIRS-EEG was performed at feature-level using CCA by maximizing the inter-subject covariance across modalities. The CCA result discovered the associations across the modalities and estimated the components responsible for these associations. The experiment results showed that mental stress experienced by this cohort of subjects is subregion specific and localized to the right ventrolateral PFC subregion. These suggest the right ventrolateral PFC as a suitable candidate region to extract biomarkers as performance indicators of neurofeedback training in stress coping.

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Section: Measurement Setupmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of mental stress effects on prefrontal cortical activities using canonical correlation analysis: an fNIRS-EEG study

Al-Shargie¹,

Tang²,

Kiguchi³

2017

Biomed. Opt. Express

108

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“…Moreover, in the example risk-seeking subject the increase in [tHb] response to low-risk seemed to be faster than to high-risk. However, it should be noted that the changes in [tHb] are based on a complex interplay between the cerebral blood flow associated with a given event and the physiological reactions provoked by the brain's functional neural response, which both underlie intra-individual variability (Heinzel et al, 2013;. The time courses of the raw signals on the single-subject level should therefore be interpreted with care.…”

Section: Fnirs and Eda Responsesmentioning

confidence: 99%

Comparison of functional near-infrared spectroscopy and electrodermal activity in assessing objective versus subjective risk during risky financial decisions

Holper¹,

Wolf²,

Tobler

2014

NeuroImage

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Risk is an important factor impacting financial decisions. Risk can be processed objectively, e.g. as variance across possible outcomes of a choice option or subjectively, e.g. as value of that variance to a given individual. The aim of the present study was to test the potential of functional near-infrared spectroscopy (fNIRS) in assessing these different ways of processing risk while subjects decided between either high or low risk financial options or a safe (risk-free) option. For comparison we simultaneously measured electrodermal activity (EDA), a well-established method in decision-making research and a core measure of affective processes. FNIRS showed that lateral prefrontal cortex responses to high risk were enhanced relative to low risk only in risk-seeking individuals but reduced relative to low risk in risk-averse individuals. This is in-line with individual-specific risk processing reflecting the subjective value of risk. By contrast, EDA showed enhanced responses to high risk, independent of individual risk attitude, in-line with the notion of objective risk processing. The dissociation between the two measures arose even though they overall were equally sensitive to detect individual risk-related differences and even though there was an increased, risk attitude-independent, temporal coherence between the two measures during high-risk conditions. Our results suggest that hemodynamic responses in lateral prefrontal cortex as measured by fNIRS reflect the subjective value of risk, whereas EDA may index the objective amount of risk people are presented with. The findings suggest that fNIRS could be a useful method for studying risk behavior in financial decisions. AbstractRisk is an important factor impacting financial decisions. Risk can be processed objectively, e.g. as variance across possible outcomes of a choice option or subjectively, e.g. as value of that variance to a given individual. The aim of the present study was to test the potential of functional near-infrared spectroscopy (fNIRS) in assessing these different ways of processing risk while subjects decided between either high or low risk financial options or a safe (risk-free) option. For comparison we simultaneously measured electrodermal activity (EDA), a well-established method in decision-making research and a core measure of affective processes. FNIRS showed that lateral prefrontal cortex responses to high risk were enhanced relative to low risk only in risk-seeking individuals but reduced relative to low risk in risk-averse individuals. This is in-line with individual-specific risk processing reflecting the subjective value of risk. By contrast, EDA showed enhanced responses to high risk, independent of individual risk attitude, in-line with the notion of objective risk processing. The dissociation between the two measures arose even though they overall were equally sensitive to detect individual risk-related differences and even though there was increased, risk attitude-independent, temporal coherence between the two me...

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“…The hemodynamic signals in the EPM1 patients, who typically lack b-ERS, had a similar time course but were significantly lessened, possibly because of their mild cortical atrophy. Heinzel et al 2013 have recently reported that up to 41 % of the variance in the HHb signal and up to 18 % of the variance in the O 2 Hb signal in frontal regions can be explained by individual grey matter volume; moreover, differences in the distance between the scalp and cortex may affect the sensitivity of fNIRS (Haeussinger et al 2011). As in previous studies of EPM1 patients (Koskenkorva et al , 2012, we found that motor area CT was moderately reduced in our patients, and correlated with the reduction in the hemodynamic signals.…”

Section: Movement-related Eeg Changes and Hemodynamicsmentioning

confidence: 99%

Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study

et al. 2014

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Multimodal human brain mapping has been proposed as an integrated approach capable of improving the recognition of the cortical correlates of specific neurological functions. We used simultaneous EEG-fMRI (functional magnetic resonance imaging) and EEG-TDfNIRS (time domain functional near-infrared spectroscopy) recordings to compare different hemodynamic methods with changes in EEG in ten patients with progressive myoclonic epilepsy and 12 healthy controls. We evaluated O 2 Hb, HHb and Blood oxygen level-dependent (BOLD) changes and event-related desynchronization/synchronization (ERD/ERS) in the a and b bands of all of the subjects while they performed a simple motor task. The general linear model was used to obtain comparable fMRI and TDfNIRS activation maps. We also analyzed cortical thickness in order to evaluate any structural changes. In the patients, the TD-NIRS and fMRI data significantly correlated and showed a significant lessening of the increase in O 2 Hb and the decrease in BOLD. The post-movement b rebound was minimal or absent in patients. Cortical thickness was moderately reduced in the motor area of the patients and correlated with the reduction in the hemodynamic signals. The fMRI and TD-NIRS results were consistent, significantly correlated and showed smaller hemodynamic changes in the patients. This finding may be partially attributable to mild cortical thickening. However, cortical hyperexcitability, which is known to generate myoclonic jerks and probably accounts for the lack of EEG b-ERS, did not reflect any increased energy requirement. We hypothesize that this is due to a loss of inhibitory neuronal components that typically fire at high frequencies.

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Variability of (functional) hemodynamics as measured with simultaneous fNIRS and fMRI during intertemporal choice

Cited by 94 publications

References 37 publications

Assessment of mental stress effects on prefrontal cortical activities using canonical correlation analysis: an fNIRS-EEG study

Assessment of mental stress effects on prefrontal cortical activities using canonical correlation analysis: an fNIRS-EEG study

Comparison of functional near-infrared spectroscopy and electrodermal activity in assessing objective versus subjective risk during risky financial decisions

Hemodynamic and EEG Time-Courses During Unilateral Hand Movement in Patients with Cortical Myoclonus. An EEG-fMRI and EEG-TD-fNIRS Study

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